Výsledky vyhledávání

Synthesis and structure–activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases

Autor: Ellen M. Dobrusin, Elizabeth A. Lunney, William A. Denny, Edward N. Baker, Andrew M. Thompson, R. John Booth, Brian D. Palmer, John Quin, Alan J. Kraker, Christopher J. Squire, Ivan Ivanovic, Daniel F. Ortwine, Ho H. Lee, Jeff B. Smaill, James M. J. Dickson, Alexander James Bridges

Publikováno v: European Journal of Medicinal Chemistry. 43:1276-1296

A series of N-6 substituted 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones were prepared from N-substituted (5-methoxyphenyl)ethenylindoles. The target compounds were tested for their ability to inhibit the G2/M cell cycle checkpoint kin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98017342f5dd35f584a09baa12e3d433
https://doi.org/10.1016/j.ejmech.2007.07.016

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No evidence for association between NOTCH4 and schizophrenia in a large family-based and case–control association analysis

Publikováno v: Psychiatric Genetics. 16:197-203

Objectives An analysis of 80 British parent–offspring trios by Wei and Hemmings in 2000 revealed thre1e out of five markers within the NOTCH4 locus to be strongly associated with schizophrenia. In our present study, we have examined NOTCH4 markers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a487c50d42e38ee391282b908a57c47a
https://doi.org/10.1097/01.ypg.0000218619.50386.7c

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Transmission disequilibrium and haplotype analyses of the G72/G30 locus: Suggestive linkage to schizophrenia in Palestinian Arabs living in the North of Israel

Autor: I. Murad, M. Dobrusin, Alina Cholostoy, U. Bening‐Abu‐Shach, Michael Korostishevsky, I. Bannoura, Wolfgang Maier, Ruth Navon, Robert H. Belmaker, M. Kaganovich, Richard P. Ebstein, Ilana Kremer, Marcella Rietschel, M. Muhaheed

Publikováno v: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. :91-95

Association of the G72/G30 locus with schizophrenia was recently reported in French Canadian, Russian, and Ashkenazi populations using case-control studies. In the present study we hypothesize the existence of a G72/G30 risk allele over-transmitted t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4514e1dce1bfe101e923c5c132bc314f
https://doi.org/10.1002/ajmg.b.30212

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The rate of consanguineous marriages among parents of schizophrenic patients in the Arab Bedouin population in Southern Israel

Autor: Marcella Rietschel, Robert H. Belmaker, Dahlia Weitzman, Joseph Levine, M. Dobrusin, Ilana Kremer, Wolfgang Maier

Publikováno v: The World Journal of Biological Psychiatry. 10:334-336

Consanguinity may contribute to the incidence of schizophrenia in offspring despite the usually accepted polygenic model of schizophrenia inheritance. Bedouin Arab families in southern Israel have a high rate of cousin marriages as do families throug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec819dab12a15acd459f5acd08b803ed
https://doi.org/10.3109/15622970701849960

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Elektronická kniha

Intellectual Property Culture: Strategies to Foster Successful Patent and Trade Secret Practices in Everyday Business

Autor: Eric M. Dobrusin, Ronald A. Krasnow

With the increasing public awareness of patents, U.S. Congress having enacted patent reform, and the U.S. Supreme Court taking on expanding numbers of patent cases, the pressure on innovation-based organizations to define and improve their intellectu

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Structure-Based Design of a Potent, Selective, and Irreversible Inhibitor of the Catalytic Domain of the erbB Receptor Subfamily of Protein Tyrosine Kinases

Autor: Juswinder Singh, and Adrian Whitty, Fry David William, Mcnamara Dennis Joseph, Ellen M. Dobrusin, Taraneh Haske

Publikováno v: Journal of Medicinal Chemistry. 40:1130-1135

We report the use of structure-based drug design to create a selective erbB-1 (a.k.a. epidermal growth factor receptor) and erbB-2 (a.k.a. neu/her2 growth factor receptor) tyrosine kinase inhibitor. Using the X-ray crystal structure of the ternary co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed94729a0a9c80b1ee60f4d593dcdcd
https://doi.org/10.1021/jm960380s

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Investigating Thought Disorder in Schizophrenia: Evidence for Pathological Activation

Autor: Avishai Henik, Ziad Safadi, M. Dobrusin, Limor Lichtenstein-Vidne

Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 12, p e82882 (2013)

Background Previous research has yielded evidence for enhanced semantic priming in formal thought-disordered schizophrenia patients, a result that fits well with the hypothesis of disinhibited processes of spreading activation in this population. Obj

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49b717cd03b00f011bb3bd2f66dc796f
http://europepmc.org/articles/PMC3855781

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A family-based study of the Cys23Ser 5HT2C serotonin receptor polymorphism in schizophrenia

Autor: Marcella Rietschel, Thomas G. Schulze, Wolfgang Maier, M. Muhaheed, I. Murad, Alon Reshef, V. Tsenter, M. Dobrusin, S. Gathas, Richard P. Ebstein, I. Bannoura, Ilana Kremer, Monica Blanaru, Daniel J. Müller, Robert H. Belmaker

Publikováno v: American Journal of Medical Genetics. 105:236-238

The 5HT2C receptor has a high affinity for clozapine, a nontypical neuroleptic, and has therefore been postulated to play a role in mediating negative symptoms and neuroleptic response in schizophrenia. In the current study, the Cys23Ser 5HT2C seroto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8df21e332f6ff84db2ae709e31980a93
https://doi.org/10.1002/ajmg.1260

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No association between the dopamine D3 receptorBal I polymorphism and schizophrenia in a family-based study of a Palestinian Arab population

Autor: I. Murad, Daniel J. Müller, Dieter B. Wildenauer, M. Blanaru, S. Gathas, Marcella Rietschel, Alon Reshef, Richard P. Ebstein, Ilana Kremer, I. Bannoura, M. Dobrusin, W. Maier, Thomas G. Schulze, S. G. Schwab, Robert H. Belmaker, Mustafa Mujaheed, Rachel Bachner-Melman

Publikováno v: American Journal of Medical Genetics. 96:778-780

Several recent meta-analyses appear to show a weak but significant effect of both forms of the gly/ser DRD3 polymorphism in conferring risk for schizophrenia. Since most studies have employed the artifact-prone case-control design, we thought it wort

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f2dd25bc4d88a5743f39f38ced07836
https://doi.org/10.1002/1096-8628(20001204)96:6<778::aid-ajmg16>3.0.co

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