Výsledky vyhledávání - "M. Diana Neely"

Akademický článek

Rescue of impaired blood-brain barrier in tuberous sclerosis complex patient derived neurovascular unit

Autor: Jacquelyn A. Brown, Shannon L. Faley, Monika Judge, Patricia Ward, Rebecca A. Ihrie, Robert Carson, Laura Armstrong, Mustafa Sahin, John P. Wikswo, Kevin C. Ess, M. Diana Neely

Publikováno v: Journal of Neurodevelopmental Disorders, Vol 16, Iss 1, Pp 1-16 (2024)

Abstract Background Tuberous sclerosis complex (TSC) is a multi-system genetic disease that causes benign tumors in the brain and other vital organs. The most debilitating symptoms result from involvement of the central nervous system and lead to a m

Externí odkaz: https://doaj.org/article/302796375aee43128c1c645409209e15

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Akademický článek

Contractile and Genetic Characterization of Cardiac Constructs Engineered from Human Induced Pluripotent Stem Cells: Modeling of Tuberous Sclerosis Complex and the Effects of Rapamycin

Autor: Veniamin Y. Sidorov, Tatiana N. Sidorova, Philip C. Samson, Ronald S. Reiserer, Clayton M. Britt, M. Diana Neely, Kevin C. Ess, John P. Wikswo

Publikováno v: Bioengineering, Vol 11, Iss 3, p 234 (2024)

The implementation of three-dimensional tissue engineering concurrently with stem cell technology holds great promise for in vitro research in pharmacology and toxicology and modeling cardiac diseases, particularly for rare genetic and pediatric dise

Externí odkaz: https://doaj.org/article/1b6f0018f0dd41908e80ffa298509186

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Akademický článek

Genomic, transcriptomic, and metabolomic profiles of hiPSC-derived dopamine neurons from clinically discordant brothers with identical PRKN deletions

Autor: Holly N. Cukier, Hyunjin Kim, Anthony J. Griswold, Simona G. Codreanu, Lisa M. Prince, Stacy D. Sherrod, John A. McLean, Derek M. Dykxhoorn, Kevin C. Ess, Peter Hedera, Aaron B. Bowman, M. Diana Neely

Publikováno v: npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-17 (2022)

Abstract We previously reported on two brothers who carry identical compound heterozygous PRKN mutations yet present with significantly different Parkinson’s Disease (PD) clinical phenotypes. Juvenile cases demonstrate that PD is not necessarily an

Externí odkaz: https://doaj.org/article/9cfa439da89548cd82667ecafd084ddb

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Akademický článek

Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington’s disease

Autor: Alba Di Pardo, Enrico Amico, Abdul Basit, Andrea Armirotti, Piyush Joshi, M. Diana Neely, Romina Vuono, Salvatore Castaldo, Anna F. Digilio, Francesco Scalabrì, Giuseppe Pepe, Francesca Elifani, Michele Madonna, Se Kyoo Jeong, Bu-Mahn Park, Maurizio D’Esposito, Aaron B. Bowman, Roger A. Barker, Vittorio Maglione

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)

Abstract Huntington’s disease is characterized by a complex and heterogeneous pathogenic profile. Studies have shown that disturbance in lipid homeostasis may represent a critical determinant in the progression of several neurodegenerative disorder

Externí odkaz: https://doaj.org/article/bf0f9516edd7471585e05c6cc1d03c10

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Akademický článek

Accelerated differentiation of human induced pluripotent stem cells to blood–brain barrier endothelial cells

Autor: Emma K. Hollmann, Amanda K. Bailey, Archit V. Potharazu, M. Diana Neely, Aaron B. Bowman, Ethan S. Lippmann

Publikováno v: Fluids and Barriers of the CNS, Vol 14, Iss 1, Pp 1-13 (2017)

Abstract Background Due to their ability to limitlessly proliferate and specialize into almost any cell type, human induced pluripotent stem cells (iPSCs) offer an unprecedented opportunity to generate human brain microvascular endothelial cells (BME

Externí odkaz: https://doaj.org/article/6330049f35a94f1ab14d2edc3d5e2da7

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Akademický článek

PARK2 patient neuroprogenitors show increased mitochondrial sensitivity to copper

Autor: Asad A. Aboud, Andrew M. Tidball, Kevin K. Kumar, M. Diana Neely, Bingying Han, Kevin C. Ess, Charles C. Hong, Keith M. Erikson, Peter Hedera, Aaron B. Bowman

Publikováno v: Neurobiology of Disease, Vol 73, Iss , Pp 204-212 (2015)

Poorly-defined interactions between environmental and genetic risk factors underlie Parkinson's disease (PD) etiology. Here we tested the hypothesis that human stem cell derived forebrain neuroprogenitors from patients with known familial risk for ea

Externí odkaz: https://doaj.org/article/a50689e8e4a94a1bbc251e240c2de139

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Akademický článek

Subcellular localization of microsomal triglyceride transfer protein

Autor: Larry L. Swift, Mei-Ying Zhu, Bharati Kakkad, Aneta Jovanovska, M. Diana Neely, Klara Valyi-Nagy, Richard L. Roberts, David E. Ong, W. Gray Jerome

Publikováno v: Journal of Lipid Research, Vol 44, Iss 10, Pp 1841-1849 (2003)

Microsomal triglyceride transfer protein (MTP) is essential for the assembly of apolipoprotein B-containing lipoproteins. Within the endoplasmic reticulum, it transfers lipid from the membrane to the forming lipoprotein. Recent evidence suggests that

Externí odkaz: https://doaj.org/article/426f98572e004e82ace3fb8534e9b38f

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Akademický článek

Gammaretroviral vector encoding a fluorescent marker to facilitate detection of reprogrammed human fibroblasts during iPSC generation

Autor: Narasimhachar Srinivasakumar, Michail Zaboikin, Andrew M. Tidball, Asad A. Aboud, M. Diana Neely, Kevin C. Ess, Aaron B. Bowman, Friedrich G. Schuening

Publikováno v: PeerJ, Vol 1, p e224 (2013)

Induced pluripotent stem cells (iPSCs) are becoming mainstream tools to study mechanisms of development and disease. They have a broad range of applications in understanding disease processes, in vitro testing of novel therapies, and potential utilit

Externí odkaz: https://doaj.org/article/9f97519539284ab0a75b831f70932044

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