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A randomized, placebo‐controlled study of theNS5B inhibitor beclabuvir with peginterferon/ribavirin forHCVgenotype 1

Autor: Reem Ghalib, Michelle Treitel, Claudia Martorell, Harvey A Tatum, J. Hanson, Paul J. Thuluvath, E. Cooney, Natarajan Ravendhran, J. Zhao, Vinod K. Rustgi, M. Demicco, J. Zamparo, Eric Lawitz, S. Cohen, Eric Hughes

Publikováno v: Journal of Viral Hepatitis. 22:658-664

Beclabuvir is a potent, non-nucleoside inhibitor of the HCV NS5B RNA polymerase, with nanomolar activity against HCV genotypes 1, 3, 4, 5 and 6 in vitro. This study evaluated the efficacy and safety of beclabuvir, in combination with peginterferon al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97082f374be76a6fab395923d1320574
https://doi.org/10.1111/jvh.12372

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Assessment of drug-drug interactions between daclatasvir and methadone or buprenorphine-naloxone

Autor: Tushar Garimella, R. D. Bruce, M. DeMicco, Reena Wang, Philip Wastall, Carey Hwang, Marc Bifano, Hamza Kandoussi, Wen-Lin Luo, Richard Bertz

Publikováno v: Antimicrobial agents and chemotherapy. 59(9)

Hepatitis C virus (HCV) infection is common among people who inject drugs, including those managed with maintenance opioids. Pharmacokinetic interactions between opioids and emerging oral HCV antivirals merit evaluation. Daclatasvir is a potent pange

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1e571c92462fe03b611070a013803f8
https://pubmed.ncbi.nlm.nih.gov/26124175

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Annealing Requirements for Flow-Formed Containment Vessels for Type B Radioactive Materials

Autor: L. Hagler, M. DeMicco, E Russell, B. L. Anderson, C. K. Syn, G. Mok, Ronald S. Hafner

Publikováno v: Volume 7: Operations, Applications and Components.

Flow forming, an advanced version of metal spinning, is becoming a popular technique for the fabrication of containers for the storage and transportation of radioactive materials. A previous article by the authors[1] gave a cursory review of the oper

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d5d5e0aee10f22440c081ca5fd45c46
https://doi.org/10.1115/pvp2012-78594

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The Role of Glycine Residues 140 and 141 of Subunit B in the Functional Ubiquinone Binding Site of the Na+-pumping NADH:quinone Oxidoreductase from Vibrio cholerae*

Autor: Jessica M. DeMicco, Erin Turk, Najat Chahboun, Petra Hellwig, Yashvin Neehaul, Blanca Barquera, Oscar Juárez

Publikováno v: The Journal of biological chemistry
The Journal of biological chemistry, 2012, 287 (30), pp.25678-25685. ⟨10.1074/jbc.M112.366088⟩

PMID: 22645140 PMCID: PMC3408181; The Na(+)-pumping NADH:quinone oxidoreductase (Na(+)-NQR) is the main entrance for electrons into the respiratory chain of many marine and pathogenic bacteria. The enzyme accepts electrons from NADH and donates them

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f71421d14fbe4c9628a44ab69dd9d49
https://europepmc.org/articles/PMC3408181/

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On The Application of Flow Forming to the Fabrication of Type B Radioactive Material Package Containment Vessels, Rev. 1

Autor: Larry E. Fischer, B. L. Anderson, L. Hagler, J. Wen, E Russell, G. Mok, M. DeMicco, Ronald S. Hafner

Flow forming is a modernized and improved version of metal spinning, which is one of the oldest methods of chipless forming. The metal spinning method used a pivoted pointer to manually push a metal sheet mounted at one end of a spinning mandrel. As

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef3c7b42c296a07bc661502b004de0be
https://doi.org/10.2172/1118017

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