Zobrazeno 1 - 10
of 293
pro vyhledávání: '"M. Delaforge"'
Autor:
M. Delaforge
Publikováno v:
Nuclear Medicine and Biology. 25:705-709
Metabolic transformation of drug leads to the formation of a large number of secondary compounds. These metabolites may (a) participate to the elimination of the patent drug, (b) have similar or different therapeutic effects compared to the parent dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0504d0c241cdd22c969fd9e2ca4fb5ad
https://doi.org/10.1016/s0969-8051(98)00063-8
https://doi.org/10.1016/s0969-8051(98)00063-8
Publikováno v:
Spectroscopy. 13:163-174
Oxidations performed on four indolic bases,β-carboline1, ibogaine2, reserpine3and ajmaline4, by hepatic cytochrome P450 (Cyt. P450) and ferrous picolinate (Fe(PA)2), lead to alicyclic hydroxylation as major reaction products.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb4e74d500a9087b0ac069e290408196
https://doi.org/10.1155/1997/364081
https://doi.org/10.1155/1997/364081
Publikováno v:
Experientia. 51:790-798
The sex-dependent effect of lauroyl-L-Ala-D-gamma-Glu-L,L-A2pmNH2 (LtriP, RP 56142) on hepatic microsomal cytochromes P 450 (cyt P 450) was studied in three mouse strains NMRI, C3H/OuJ and C3H/HeJ. In NMRI and C3H/OuJ, strains which are responsive to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5735b7f87fd55e899775ba0463b9716
https://doi.org/10.1007/bf01922432
https://doi.org/10.1007/bf01922432
Publikováno v:
Drug and Chemical Toxicology. 13:325-346
p-125I-amphetamine (I-Amp) is retained significantly in liver and lung during brain tomoscintigraphy. To attempt to explain this clinical observation, we have investigated the interaction of I-Amp with rat liver and lung microsomal proteins. Studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd7bdf4765af7521b1978aed46632313
https://doi.org/10.3109/01480549009032290
https://doi.org/10.3109/01480549009032290
Publikováno v:
Advances in experimental medicine and biology. 500
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f373bf70c4b408e88fd8dd5e6c109314
https://pubmed.ncbi.nlm.nih.gov/11764940
https://pubmed.ncbi.nlm.nih.gov/11764940
Autor:
C, Aninat, M, Delaforge
Publikováno v:
Advances in experimental medicine and biology. 500
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c384a517f4f293b41fccf92664fc7d8d
https://pubmed.ncbi.nlm.nih.gov/11764963
https://pubmed.ncbi.nlm.nih.gov/11764963
Autor:
C. Aninat, M. Delaforge
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461351856
Roquefortine, a cyclodipeptide derived from the diketopiperazine cyclo (TrpdehydroHis), is a secondary metabolite produced by some Penicillium species (1,2). P. roqueforti is considered as one of the most important fungal contaminants of carbonated b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64c7d206e69c1346ffda098b473c5e96
https://doi.org/10.1007/978-1-4615-0667-6_52
https://doi.org/10.1007/978-1-4615-0667-6_52
Publikováno v:
British journal of pharmacology. 126(1)
1. Arachidonic acid (0.01-1 microM) induced relaxation of precontracted rings of rabbit saphenous vein, which was counteracted by contraction at concentrations higher than 1 microM. Concentrations higher than 1 microM were required to induce dose-dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4040a2727587c7312a4e4d445728d542
https://pubmed.ncbi.nlm.nih.gov/10051118
https://pubmed.ncbi.nlm.nih.gov/10051118
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 282(3)
Bromocriptine (BCT) is a dopamine D2 receptor agonist used for the treatment of Parkinson's disease and hyperprolactinemic disorders. After oral administration, BCT is metabolized into mono- or dihydroxylated metabolites. To study how these metabolit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::684d394e60a4136f138df802de1792f0
https://pubmed.ncbi.nlm.nih.gov/9316855
https://pubmed.ncbi.nlm.nih.gov/9316855
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 274(2)
18-Nitro-oxyandrostenedione (18-ONO2A), a potential mechanism-based inhibitor of the last steps of aldosterone biosynthesis, is well recognized by different cytochrome P-450s, which are able to metabolize it reductively into nitric oxide (NO) and 18-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4839abf1e3adc595eb08a2449cf3443
https://pubmed.ncbi.nlm.nih.gov/7636722
https://pubmed.ncbi.nlm.nih.gov/7636722