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Akademický článek

Multimodal image-guided surgery of HER2-positive breast cancer using [111In]In-DTPA-trastuzumab-IRDye800CW in an orthotopic breast tumor model

Autor: Marion M. Deken, Desirée L. Bos, Willemieke S. F. J. Tummers, Taryn L. March, Cornelis J. H. van de Velde, Mark Rijpkema, Alexander L. Vahrmeijer

Publikováno v: EJNMMI Research, Vol 9, Iss 1, Pp 1-10 (2019)

Abstract Background Combining modalities using dual-labeled antibodies may allow preoperative and intraoperative tumor localization and could be used in image-guided surgery to improve complete tumor resection. Trastuzumab is a monoclonal antibody ag

Externí odkaz: https://doaj.org/article/2184bff468d144f1af4acca02ef9791e

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Akademický článek

A zwitterionic near-infrared fluorophore for real-time ureter identification during laparoscopic abdominopelvic surgery

Autor: Kim S. de Valk, Henricus J. Handgraaf, Marion M. Deken, Babs G. Sibinga Mulder, Adrianus R. Valentijn, Anton G. Terwisscha van Scheltinga, Joeri Kuil, Michiel J. van Esdonk, Jaap Vuijk, Rob F. Bevers, Koen C. Peeters, Fabian A. Holman, John V. Frangioni, Jacobus Burggraaf, Alexander L. Vahrmeijer

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-6 (2019)

Iatrogenic injury of the ureters is a feared complication of laparoscopic abdominal surgery. Here the authors present the NIR fluorophore ZW800-1 as an intraoperative imaging agent for ureter mapping, showing its safety, pharmacokinetic properties, a

Externí odkaz: https://doaj.org/article/ee290759ae054fec9dc8492256ab1fea

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Akademický článek

Small Molecules for Multi-Wavelength Near-Infrared Fluorescent Mapping of Regional and Sentinel Lymph Nodes in Colorectal Cancer Staging

Autor: Victor M. Baart, Marion M. Deken, Mark W. Bordo, Shadhvi S. Bhairosingh, Daniela C. F. Salvatori, Hoon Hyun, Maged Henary, Hak Soo Choi, Cornelis F. M. Sier, Peter J. K. Kuppen, Anton G. T. Terwisscha van Scheltinga, Taryn L. March, Adrianus R. P. M. Valentijn, John V. Frangioni, Alexander L. Vahrmeijer

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

Assessing lymph node (LN) status during tumor resection is fundamental for the staging of colorectal cancer. Current guidelines require a minimum of 12 LNs to be harvested during resection and ultra-staging regional lymph nodes by sentinel lymph node

Externí odkaz: https://doaj.org/article/7749da070ace46c38b502ef1f930c9ab

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Table S1, Table S2, Fig S1, Fig S2, Fig S3, Fig S4 from First-in-Human Assessment of cRGD-ZW800-1, a Zwitterionic, Integrin-Targeted, Near-Infrared Fluorescent Peptide in Colon Carcinoma

Autor: Alexander L. Vahrmeijer, Jacobus Burggraaf, John V. Frangioni, J. Sven D. Mieog, Denise E. Hilling, Fabian A. Holman, Koen C.M.J. Peeters, Jaap Vuijk, Taryn L. March, A. Rob P.M. Valentijn, Anton G.T. Terwisscha van Scheltinga, Michiel J. van Esdonk, Okker D. Bijlstra, Shadhvi S. Bhairosingh, Henricus J.M. Handgraaf, Marion M. Deken, Kim S. de Valk

Supplementary Data

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::396e5c9403ede91aedb317073f20b388
https://doi.org/10.1158/1078-0432.22476917.v1

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Data from First-in-Human Assessment of cRGD-ZW800-1, a Zwitterionic, Integrin-Targeted, Near-Infrared Fluorescent Peptide in Colon Carcinoma

Purpose:Incomplete oncologic resections and damage to vital structures during colorectal cancer surgery increases morbidity and mortality. Moreover, neoadjuvant chemoradiotherapy has become the standard treatment modality for locally advanced rectal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d0680f6b7e0dc10cb1808c40fcf076e
https://doi.org/10.1158/1078-0432.c.6529526.v1

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A multimodal molecular imaging approach targeting urokinase plasminogen activator receptor for the diagnosis, resection and surveillance of urothelial cell carcinoma

Autor: Massimo Resnati, Victor M Baart, Rob C.M. Pelger, Timo Schomann, Peter J. K. Kuppen, Maaike H. van der Mark, Vincent Q. Sier, Hugo de Jonge, Gabriel van der Pluijm, Marion M. Deken, Luisa Iamele, Shadhvi S. Bhairosingh, Alexander L. Vahrmeijer, Andrew P. Mazar, Cornelis F. M. Sier, Geertje van der Horst

Publikováno v: European Journal of Cancer
European Journal of Cancer, 146, 11-20. ELSEVIER SCI LTD

With a 5-year recurrence rate of 30-78%, urothelial cell carcinoma (UCC) rates amongst the highest of all solid malignancies. Consequently, after transurethral resection, patients are subjugated to life-long endoscopic surveillance. A multimodal near

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89deef8a90f2fda9ae57dee4c5047e85
https://doi.org/10.1016/j.ejca.2021.01.001

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Dose-Finding Study of a CEA-Targeting Agent, SGM-101, for Intraoperative Fluorescence Imaging of Colorectal Cancer

Autor: Shadhvi S. Bhairosingh, Koen C.M.J. Peeters, Dennis P. Schaap, Kim S. de Valk, Charlotte E.S. Hoogstins, Denise E. Hilling, Bérénice Framery, Fabian A. Holman, Leonora S.F. Boogerd, Miranda Kusters, Maxime J M van der Valk, Françoise Cailler, Marion M. Deken, Jacobus Burggraaf, Ruben P J Meijer, Harm J. T. Rutten, Ingrid M C Kamerling, Alexander L. Vahrmeijer

Publikováno v: Annals of Surgical Oncology, 28, 1832-1844. SPRINGER
Annals of surgical oncology, 28(3), 1832-1844. Springer New York
Annals of Surgical Oncology, 28(3), 1832-1844. Springer New York
Annals of Surgical Oncology
de Valk, K S, Deken, M M, Schaap, D P, Meijer, R P, Boogerd, L S, Hoogstins, C E, van der Valk, M J, Kamerling, I M, Bhairosingh, S S, Framery, B, Hilling, D E, Peeters, K C, Holman, F A, Kusters, M, Rutten, H J, Cailler, F, Burggraaf, J & Vahrmeijer, A L 2021, ' Dose-Finding Study of a CEA-Targeting Agent, SGM-101, for Intraoperative Fluorescence Imaging of Colorectal Cancer ', Annals of Surgical Oncology, vol. 28, no. 3, pp. 1832-1844 . https://doi.org/10.1245/s10434-020-09069-2

BackgroundCarcinoembryonic antigen is overexpressed in colorectal cancer (CRC), making it an optimal target for fluorescence imaging. A phase I/II study was designed to determine the optimal imaging dose of SGM-101 for intraoperative fluorescence ima

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8459e9d0dca4d305c1b07195f390feed
http://www.scopus.com/inward/record.url?scp=85092351518&partnerID=8YFLogxK

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Orthotopic Breast Cancer Model to Investigate the Therapeutic Efficacy of Nanobody-Targeted Photodynamic Therapy

Autor: Marion M, Deken, Shadhvi S, Bhairosingh, Alexander L, Vahrmeijer, Sabrina, Oliveira

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2451

Photodynamic therapy (PDT) is characterized by the local application of laser light, which activates a photosensitizer to lead to the formation of singlet oxygen and other toxic reactive oxygen species, to finally kill cells. Recently, photosensitize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d25bca51e0d4edf2d6bc9645dbc2ebcf
https://pubmed.ncbi.nlm.nih.gov/35505031

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