Zobrazeno 1 - 10
of 607
pro vyhledávání: '"M. De Robertis"'
Autor:
Ulrik Ringborg, Joachim vonBraun, Julio Celis, Michael Baumann, Anton Berns, Alexander Eggermont, Edith Heard, Manuel Heitor, Mammen Chandy, Chien‐Jen Chen, Alberto Costa, Francesco De Lorenzo, Edward M. De Robertis, Frederick Charles Dubee, Ingemar Ernberg, Mariya Gabriel, Åslaug Helland, Rui Henrique, Bengt Jönsson, Olli Kallioniemi, Jan Korbel, Mechthild Krause, Douglas R. Lowy, Olivier Michielin, Peter Nagy, Simon Oberst, Vincenzo Paglia, M. Iqbal Parker, Kevin Ryan, Charles L. Sawyers, Joachim Schüz, Katherine Silkaitis, Eric Solary, David Thomas, Peter Turkson, Elisabete Weiderpass, Huanming Yang
Publikováno v:
Molecular Oncology, Vol 18, Iss 2, Pp 245-279 (2024)
Analyses of inequalities related to prevention and cancer therapeutics/care show disparities between countries with different economic standing, and within countries with high Gross Domestic Product. The development of basic technological and biologi
Externí odkaz:
https://doaj.org/article/aed58f51906b40f3875630c0b7d33c89
Autor:
Nydia Tejeda-Muñoz, Yagmur Azbazdar, Eric A. Sosa, Julia Monka, Pu-Sheng Wei, Grace Binder, Kuo-Ching Mei, Yerbol Z. Kurmangaliyev, Edward M. De Robertis
Publikováno v:
Biology Open, Vol 13, Iss 5 (2024)
Externí odkaz:
https://doaj.org/article/8209293db1834421b783329a357b4e1a
Autor:
Eric Sosa, Edward M. De Robertis
Publikováno v:
Molecular & Cellular Oncology, Vol 10, Iss 1 (2023)
Chordin (CHRD) is a secreted protein important in early development, yet a role for CHRD in human disease has not been identified. In this study we investigated CHRD in cancer and normal adult tissues using the wealth of genome-wide data available in
Externí odkaz:
https://doaj.org/article/1b270da3ab324d43a2231446f45bed00
Autor:
Nydia Tejeda-Munoz, Yagmur Azbazdar, Julia Monka, Grace Binder, Alex Dayrit, Raul Ayala, Neil O'Brien, Edward M De Robertis
Publikováno v:
eLife, Vol 12 (2023)
Activation of the Wnt pathway lies at the core of many human cancers. Wnt and macropinocytosis are often active in the same processes, and understanding how Wnt signaling and membrane trafficking cooperate should improve our understanding of embryoni
Externí odkaz:
https://doaj.org/article/c050ab64f51242de82c4d3fd42c3621a
Autor:
Yagmur Azbazdar, Nydia Tejeda-Munoz, Julia C. Monka, Alex Dayrit, Grace Binder, Gunes Ozhan, Edward M. De Robertis
Publikováno v:
iScience, Vol 26, Iss 10, Pp 108075- (2023)
Summary: Activation of Wnt signaling triggers macropinocytosis and drives many tumors. We now report that the exogenous addition of the second messenger lipid sn-1,2 DAG to the culture medium rapidly induces macropinocytosis. This is accompanied by p
Externí odkaz:
https://doaj.org/article/e2b67310fbdd4d52b43b54a2b772dc95
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101455- (2022)
Summary: The Xenopus embryo provides an advantageous model system where genes can be readily transplanted as DNA or mRNA or depleted with antisense techniques. Here, we present a protocol to culture and image the cell biological properties of explant
Externí odkaz:
https://doaj.org/article/74cf5304b1b644ab8073ece6bb6bc03a
Autor:
Gabriele Colozza, Yasaman Jami-Alahmadi, Alyssa Dsouza, Nydia Tejeda-Muñoz, Lauren V. Albrecht, Eric A. Sosa, James A. Wohlschlegel, Edward M. De Robertis
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract The canonical Wnt pathway serves as a hub connecting diverse cellular processes, including β-catenin signaling, differentiation, growth, protein stability, macropinocytosis, and nutrient acquisition in lysosomes. We have proposed that seque
Externí odkaz:
https://doaj.org/article/70bc8e647cea4e6a97568c3d15403f70
Autor:
Nydia Tejeda-Muñoz, Marco Morselli, Yuki Moriyama, Pooja Sheladiya, Matteo Pellegrini, Edward M. De Robertis
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104123- (2022)
Summary: During canonical Wnt signaling, the Wnt receptor complex is sequestered together with glycogen synthase kinase 3 (GSK3) and Axin inside late endosomes, known as multivesicular bodies (MVBs). Here, we present experiments showing that Wnt caus
Externí odkaz:
https://doaj.org/article/cbfd10f4bdd549a2aabbfdfecb58b5b7
Autor:
Lauren V. Albrecht, Nydia Tejeda-Muñoz, Maggie H. Bui, Andrew C. Cicchetto, Daniele Di Biagio, Gabriele Colozza, Ernst Schmid, Stefano Piccolo, Heather R. Christofk, Edward M. De Robertis
Publikováno v:
Cell Reports, Vol 32, Iss 4, Pp 107973- (2020)
Summary: Canonical Wnt signaling is emerging as a major regulator of endocytosis. Here, we report that Wnt-induced macropinocytosis is regulated through glycogen synthase kinase 3 (GSK3) and the β-catenin destruction complex. We find that mutation o
Externí odkaz:
https://doaj.org/article/755ba4acfcda4998a5b3697ba8f76315
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