Zobrazeno 1 - 10
of 874
pro vyhledávání: '"M. De Lange"'
Autor:
Anneke L. Eerkens, Koen Brummel, Annegé Vledder, Sterre T. Paijens, Marta Requesens, Dominik Loiero, Nienke van Rooij, Annechien Plat, Floris-Jan Haan, Patty Klok, Refika Yigit, Thijs Roelofsen, Natascha M. de Lange, Rie Klomp, David Church, Arja ter Elst, René Wardenaar, Diana Spierings, Floris Foijer, Viktor Hendrik Koelzer, Tjalling Bosse, Joost Bart, Mathilde Jalving, Anna K. L. Reyners, Marco de Bruyn, Hans W. Nijman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Neoadjuvant immune checkpoint blockade (ICB) has shown unprecedented activity in mismatch repair deficient (MMRd) colorectal cancers, but its effectiveness in MMRd endometrial cancer (EC) remains unknown. In this investigator-driven, phase I
Externí odkaz:
https://doaj.org/article/1b7aedf643dd44ed914769ada0de8d61
Publikováno v:
SA Journal of Industrial Psychology, Vol 29, Iss 2 (2003)
The purpose of this study was to test the assumption that the utilisation of competency-based, multi-dimensional, multiple-rater performance ratings would result in reliable and useful measurements of the performance of managers (N=200) in a specific
Externí odkaz:
https://doaj.org/article/1e42065659c445419d1799ec1f99b597
Publikováno v:
Human Biology and Public Health, Vol 2 (2023)
Background: Linear enamel hypoplasia (LEH) and porous cranial lesions such as cribra orbitalia (CO) and porotic hyperostosis (PH) are considered nonspecific indicators of early childhood metabolic stress. Objectives: The study aims to describe the
Externí odkaz:
https://doaj.org/article/dabf6678e4c84de8b01b6096d243794e
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4960 (2023)
Alzheimer’s disease (AD) is an aging-related neurodegenerative disease, leading to the progressive loss of memory and other cognitive functions. As there is still no cure for AD, the growth in the number of susceptible individuals represents a majo
Externí odkaz:
https://doaj.org/article/de34d7a979e141c8900491cc9ccd2cc9
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1764 (2022)
The bidirectional pulsatile movement of cerebrospinal fluid (CSF), instead of the traditionally believed unidirectional and constant CSF circulation, has been demonstrated. In the present study, the structure and parameters of the CSF compartments we
Externí odkaz:
https://doaj.org/article/6322cb82e42441bb9ce9a278b8f1cf65
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238397 (2020)
The development of drugs targeting the brain still faces a high failure rate. One of the reasons is a lack of quantitative understanding of the complex processes that govern the pharmacokinetics (PK) of a drug within the brain. While a number of mode
Externí odkaz:
https://doaj.org/article/fece898c5d4c452ba383484fb8383d93
Autor:
Genevieve L. Evans, Daniel P. Furkert, Nacim Abermil, Preeti Kundu, Katrina M. de Lange, Emily J. Parker, Margaret A. Brimble, Edward N. Baker, J. Shaun Lott
Publikováno v:
Data in Brief, Vol 15, Iss , Pp 1019-1029 (2017)
There are twenty-five published structures of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (Mtb-AnPRT) that use the same crystallization protocol. The structures include protein complexed with natural and alternative substrates,
Externí odkaz:
https://doaj.org/article/5c6539f806014fd3a63a51b4a3d201bc
Publikováno v:
Drug Metabolism Reviews; Feb2024, Vol. 56 Issue 1, p1-30, 30p
Autor:
Xiaomei Chen, Tim Slättengren, Elizabeth C. M. de Lange, David E. Smith, Margareta Hammarlund-Udenaes
Publikováno v:
Fluids and Barriers of the CNS, Vol 14, Iss 1, Pp 1-14 (2017)
Abstract Background Atenolol, a hydrophilic beta blocker, has been used as a model drug for studying passive permeability of biological membranes such as the blood–brain barrier (BBB) and the intestinal epithelium. However, the extent of S-atenolol
Externí odkaz:
https://doaj.org/article/80dccf4a35b64600953d95d7898810b9
Publikováno v:
Pharmaceutical Research. 39:1343-1361
Micrometastatic brain tumor cells, which cause recurrence of malignant brain tumors, are often protected by the intact blood–brain barrier (BBB). Therefore, it is essential to deliver effective drugs across not only the disrupted blood-tumor barrie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96d4b18dba11ec03b85f0601e089dd4f
https://doi.org/10.1007/s11095-021-03154-1
https://doi.org/10.1007/s11095-021-03154-1