An Unconventional Gabaergic Circuit Differently Controls Pyramidal Neuron Activity in Two Visual Cortical Areas Via Endocannabinoids

Autor: Giovanni Marsicano, Joana Lourenço, M. De Brito Van Velze, Andrea Aguirre, M. Montmerle, Jérémy Peixoto, Fani Koukouli, Francisca Julio-Kalajzić, Marjorie Varilh, Alberto Bacci, Pablo Mendez, C. Allene, O. Schlueter, N. Rebola, Vikash Choudhary

Publikováno v: SSRN Electronic Journal.

SummaryPerisomatic inhibition of neocortical pyramidal neurons (PNs) coordinates cortical network activity during sensory processing, and it has been mainly attributed to parvalbumin-expressing basket cells (BCs). However, cannabinoid receptor type 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17d34ffd11d153c7daf0aa9ea96126ad
https://doi.org/10.2139/ssrn.3924603

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RHEB/mTOR hyperactivity causes cortical malformations and epileptic seizures through increased axonal connectivity.

Autor: Proietti Onori M; Department of Neuroscience, Erasmus Medical Center, Rotterdam, the Netherlands.; The ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus Medical Center, Rotterdam, the Netherlands., Koene LMC; Department of Neuroscience, Erasmus Medical Center, Rotterdam, the Netherlands.; The ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus Medical Center, Rotterdam, the Netherlands., Schäfer CB; Department of Neuroscience, Erasmus Medical Center, Rotterdam, the Netherlands., Nellist M; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, Zuid Holland, the Netherlands., de Brito van Velze M; Department of Neuroscience, Erasmus Medical Center, Rotterdam, the Netherlands., Gao Z; Department of Neuroscience, Erasmus Medical Center, Rotterdam, the Netherlands., Elgersma Y; Department of Neuroscience, Erasmus Medical Center, Rotterdam, the Netherlands.; The ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, Zuid Holland, the Netherlands., van Woerden GM; Department of Neuroscience, Erasmus Medical Center, Rotterdam, the Netherlands.; The ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, Zuid Holland, the Netherlands.

Publikováno v: PLoS biology [PLoS Biol] 2021 May 26; Vol. 19 (5), pp. e3001279. Date of Electronic Publication: 2021 May 26 (Print Publication: 2021).