Výsledky vyhledávání - "M. David Ullman"

Akademický článek

Autor: Peter McCaffery, James Evans, Omanand Koul, Amy Volpert, Kevin Reid, M. David Ullman

Publikováno v: Journal of Lipid Research, Vol 43, Iss 7, Pp 1143-1149 (2002)

Retinoic acid (RA) mediates most of the biological effects of vitamin A that are essential for vertebrate survival. It acts through binding to receptors that belong to the nuclear receptor transcription factor superfamily (Mangelsdorf et al. 1994). I

Externí odkaz: https://doaj.org/article/5b4138e1b6c64b7bbdaec8bbdd35380f

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Insulin degrading enzyme is localized predominantly at the cell surface of polarized and unpolarized human cerebrovascular endothelial cell cultures

Autor: Kelly J. Conn, Isabel Carreras, Ana M. George, Ann C. McKee, Wenwu Gao, Richard E. Fine, John M. Wells, John A. Lynch, Patricia B. Eisenhauer, M. David Ullman

Publikováno v: Journal of Neuroscience Research. 83:1262-1270

Insulin degrading enzyme (IDE) is expressed in the brain and may play an important role there in the degradation of the amyloid beta peptide (Abeta). Our results show that cultured human cerebrovascular endothelial cells (HCECs), a primary component

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae987982e10f92b70f6b55c046b966fe
https://doi.org/10.1002/jnr.20809

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Upregulation of clusterin/apolipoprotein J in lactacystin-treated SH-SY5Y cells

Autor: Rosemary Garrett-Young, Kelly J. Conn, John M. Wells, Richard E. Fine, Isabel Carreras, Patricia B. Eisenhauer, M. David Ullman

Publikováno v: Journal of Neuroscience Research. 79:495-502

Clusterin (apolipoprotein J) is a highly conserved, multifunctional, vertebrate glycoprotein. Several isoforms of clusterin have been described including the predominant secreted isoform (sCLU) and several nuclear isoforms (nCLU) associated with cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0fdca19807ef758e3df5c2ba1a1fb9
https://doi.org/10.1002/jnr.20374

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Ethanol increases retinoic acid production in cerebellar astrocytes and in cerebellum

Autor: Peter McCaffery, Na Chen, Deborah Smith, Joseph L. Napoli, M. David Ullman, Omanand Koul

Publikováno v: Developmental Brain Research. 153:233-241

Several characteristics of fetal alcohol syndrome (FAS) are similar to the teratogenic effects of retinoic acid (RA) exposure. It has been suggested that FAS may result from ethanol-induced alteration in endogenous RA synthesis, leading to abnormal e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4771a17a2b72aa9075767b683dcdde1
https://doi.org/10.1016/j.devbrainres.2004.09.003

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Insulin degrading enzyme is expressed in the human cerebrovascular endothelium and in cultured human cerebrovascular endothelial cells

Autor: Hamant S. Thatte, Patricia B. Eisenhauer, M. David Ullman, Kelly J. Conn, John A. Lynch, John M. Wells, Ann C. McKee, Richard E. Fine, Wenwu Gao

Publikováno v: Neuroscience Letters. 371:6-11

Insulin degrading enzyme (IDE) is found in the cytosol, peroxisomes and plasma membrane of many cells. Although it preferentially cleaves insulin it can also cleave many other small proteins with diverse sequences including the monomeric form of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8768169bf09e1eddeccb8474e76a56d
https://doi.org/10.1016/j.neulet.2004.07.034

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[Untitled]

Autor: Patricia B. Eisenhauer, M. David Ullman, Kelly J. Conn, John M. Wells, Richard E. Fine, Michelle J. Larned

Publikováno v: Neurochemical Research. 28:1873-1881

cDNA microarray analysis of 1-methyl-4-phenyl-pyridinium (MPP+) toxicity (1 mM, 72 h) in undifferentiated SH-SY5Y cells identified 48 genes that displayed a signal intensity greater than the mean of all differentially expressed genes and a two-fold o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bdb53a644cfeaec1eb5f3a51d9689b05
https://doi.org/10.1023/a:1026179926780

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Specific up-regulation of GADD153/CHOP in 1-methyl-4-phenyl-pyridinium-treated SH-SY5Y cells

Autor: Patricia B. Eisenhauer, Richard E. Fine, M. David Ullman, Catherine McKeon-O'Malley, Wenwu Gao, John M. Wells, Kelly J. Conn

Publikováno v: Journal of Neuroscience Research. 68:755-760

Growth arrest DNA damage-inducible 153 (GADD153) expression was increased in 1-methyl-4-phenyl-pyridinium (MPP(+))-treated human SH-SY5Y neuroblastoma cells as determined by gene microarray analysis. GADD153 expression increased after 24 hr of MPP(+)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e65fa56e59af7919669f909af69100f
https://doi.org/10.1002/jnr.10252

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Effect of Androgen Deficiency on the Human Meibomian Gland and Ocular Surface1

Autor: Jennifer M. Cermak, Reza Dana, David A. Sullivan, M. David Ullman, Dorothy Bazzinotti Tolls, James E. Evans, Kathleen L. Krenzer

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 85:4874-4882

The purpose of this study was to determine whether the chronic use of antiandrogen medications leads to meibomian gland dysfunction, altered lipid profiles in meibomian gland secretions, decreased tear film stability, and evaporative dry eye. Subject

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f01ac1a2f142b0e03ca0f29fed508fdd
https://doi.org/10.1210/jcem.85.12.7072

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PC12 cells transfected with a C-terminal fragment of the amyloid precursor protein (APP C-100), exhibit enhanced sensitivity to the calcium ionophore A23187, and diminished sensitivity to hydrogen peroxide

Autor: M. David Ullman, Richard E. Fine, John M. Wells, Catherine McKeon-O'Malley, Ladislav Volicer

Publikováno v: Molecular Brain Research. 72:103-107

Extracellular neuritic plaques are a hallmark of Alzheimer's disease. The core protein of plaques is Abeta, a 39-43 amino acid peptide derived from the amyloid precursor protein (APP). APP C-100 is a C-terminal fragment of APP, 100 amino acids long,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9af9ce38e061559a06393137be6a16b
https://doi.org/10.1016/s0169-328x(99)00228-4

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Androgens and Dry Eye in Sjogren's Syndromea

Autor: Eduardo Rocha, Flavio Jaime Rocha, L. Alexandra Wickham, Reza Dana, Jianping Gao, R W Lambert, R S Kelleher, Lilia Aikawa da Silveira, David A. Sullivan, Kathleen L. Krenzer, Elcio Hideo Sato, Masafumi Ono, M. David Ullman, Jennifer M. Cermak, Dorothy Bazzinotti Tolls, Ikuko Toda, Benjamin Sullivan, Rebecca J. Steagall

Publikováno v: Annals of the New York Academy of Sciences. 876:312-324

Sjogren's syndrome is an extremely complex and currently incurable autoimmune disorder, which occurs primarily in females, and is associated with lacrimal gland inflammation, meibomian gland dysfunction, and severe dry eye. We hypothesize that androg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfd49f7c94330653382c93789ba5dd73
https://doi.org/10.1111/j.1749-6632.1999.tb07656.x

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