Zobrazeno 1 - 10 of 1 159 pro vyhledávání: '"M. Danhof"'
1
Akademický článek
A simple HPLC-fluorescence method for the measurement of R,S-sotalol in the plasma of patients with life-threatening cardiac arrhythmias
Autor: S.R. Santos, O. Papini, C.E. Omosako, M.D. Pereira, T.B.G. Quintavalle, M.F. Riccio, A. Kurata, V.A. Pereira, G. Di-Pietro, O.E. Della-Paschoa, M. Danhof, P.L. Da-Luz
Publikováno v: Brazilian Journal of Medical and Biological Research, Vol 33, Iss 2, Pp 199-204 (2000)
R,S-sotalol, a ß-blocker drug with class III antiarrhythmic properties, is prescribed to patients with ventricular, atrial and supraventricular arrhythmias. A simple and sensitive method based on HPLC-fluorescence is described for the quantification
Externí odkaz: https://doaj.org/article/a7d954bb9e014044a061f67ebfee46ab
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2
Akademický článek
Diclofenac plasma protein binding: PK-PD modelling in cardiac patients submitted to cardiopulmonary bypass
Autor: J.O. Auler Jr., E.B. Espada, E. Crivelli, T.B.G. Quintavalle, A. Kurata, N.A.G. Stolf, A.M. Issy, O.E.D. Paschoa, M. Danhof, D.D. Breimer, D.A.F. Chamone, S.R.C.J. Santos
Publikováno v: Brazilian Journal of Medical and Biological Research, Vol 30, Iss 3, p 369 (1997)
Twenty-four surgical patients of both sexes without cardiac, hepatic, renal or endocrine dysfunctions were divided into two groups: 10 cardiac surgical patients submitted to myocardial revascularization and cardiopulmonary bypass (CPB), 3 females and
Externí odkaz: https://doaj.org/article/a651b9218f00466aa9c4c758e5af4e40
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3
Akademický článek
Understanding the Behavior of Systems Pharmacology Models Using Mathematical Analysis of Differential Equations: Prolactin Modeling as a Case Study
Autor: S Bakshi, EC de Lange, PH van der Graaf, M Danhof, LA Peletier
Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 5, Iss 7, Pp 339-351 (2016)
In this tutorial, we introduce basic concepts in dynamical systems analysis, such as phase‐planes, stability, and bifurcation theory, useful for dissecting the behavior of complex and nonlinear models. A precursor‐pool model with positive feedbac
Externí odkaz: https://doaj.org/article/a1169af7c597432ba02e9df3f1784dbc
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5
Levofloxacin-Induced QTc Prolongation Depends on the Time of Drug Administration
Autor: L, Kervezee, V, Gotta, J, Stevens, W, Birkhoff, Imc, Kamerling, M, Danhof, J H, Meijer, J, Burggraaf
Publikováno v: CPT: Pharmacometrics & Systems Pharmacology
Understanding the factors influencing a drug's potential to prolong the QTc interval on an electrocardiogram is essential for the correct evaluation of its safety profile. To explore the effect of dosing time on drug-induced QTc prolongation, a rando
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fd3f988d4c39e1514cfb542589aa34ee
https://pubmed.ncbi.nlm.nih.gov/28142221
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6
Inter-study variability of preclinical in vivo safety studies and translational exposure-QTc relationships--a PKPD meta-analysis
Autor: V, Gotta, F, Cools, K, van Ammel, D J, Gallacher, S A G, Visser, F, Sannajust, P, Morissette, M, Danhof, P H, van der Graaf
Publikováno v: British journal of pharmacology. 172(17)
Preclinical cardiovascular safety studies (CVS) have been compared between facilities with respect to their sensitivity to detect drug-induced QTc prolongation (ΔQTc). Little is known about the consistency of quantitative ΔQTc predictions that are
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::760c0e45bdc1cce98eefeb5f226b67cb
https://pubmed.ncbi.nlm.nih.gov/26076100
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8
Comparative population pharmacokinetics of lorazepam and midazolam during long-term continuous infusion in critically ill patients
Autor: Eleonora L. Swart, M. Danhof, Robert M. J. Strack van Schijndel, Lambertus G. Thijs, Klaas P. Zuideveld, Joost de Jongh
Publikováno v: British Journal of Clinical Pharmacology. 57:135-145
CorrespondenceDr E. Swart, Vrije Universiteit Medical Center, Department of Pharmacy, PO Box 7057, 1007 MB Amsterdam, the Netherlands.Tel: + 31 2044 43524Fax: + 31 2044 43525E-mail: el.swart@vumc.nlKeywordsintensive care unit, lorazepam, midazolam, p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3b512f7c7b73f489bce0224c79e58b3
https://doi.org/10.1046/j.1365-2125.2003.01957.x
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9
Drug effects on the CVS in conscious rats: separating cardiac output into heart rate and stroke volume using PKPD modelling
Autor: N, Snelder, B A, Ploeger, O, Luttringer, D F, Rigel, F, Fu, M, Beil, D R, Stanski, M, Danhof
Publikováno v: British journal of pharmacology. 171(22)
Previously, a systems pharmacology model was developed characterizing drug effects on the interrelationship between mean arterial pressure (MAP), cardiac output (CO) and total peripheral resistance (TPR). The present investigation aims to (i) extend
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eda0231f9f78d01e9ea2f6fb18608fc2
https://pubmed.ncbi.nlm.nih.gov/24962208
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10
[Untitled]
Autor: M. Danhof, J von Frijtag, Josy M. Gubbens-Stibbe, E Tukker, D Künzel, Eugene H. Cox, P H van der Graaf, M Garrido, Adriaan P. IJzerman
Publikováno v: Pharmaceutical Research. 17:653-659
Purpose. The objective of this investigation was to determine theinfluence of pre-treatment with the irreversible μ-opioid receptorantagonist β-funaltrexamine (β-FNA) on thepharmacokinetic-pharmacodynamic (PK/PD) relationship of alfentanil in rats
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c80d351949ae3b4e86b29f388c8832e
https://doi.org/10.1023/a:1007513812018
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