Zobrazeno 1 - 10
of 10
pro vyhledávání: '"M. D. W. G. Krekels"'
Autor:
Lieve Dillen, J. Van Heusden, G. Smets, W. Wouters, F. C. S. Ramaekers, M. D. W. G. Krekels, M. Borgers
Publikováno v:
British Journal of Cancer
The clinical use of all-trans-retinoic acid (ATRA) in the treatment of cancer is significantly hampered by the prompt emergence of resistance, believed to be caused by increased ATRA catabolism. Inhibitors of ATRA catabolism may therefore prove valua
Autor:
J. Van Dun, Lieve Dillen, M. D. W. G. Krekels, A. Verhoeven, W. Wouters, C. Van Hove, M.-C. Coene, W. Cools
Publikováno v:
British Journal of Cancer
Cytochrome P450-dependent oxidation is a pathway for all-trans-retinoic acid (all-trans-RA) catabolism. Induction of this catabolic pathway was studied in MCF-7 breast cancer cells. MCF-7 cells showed low constitutive all-trans-RA catabolism. Concent
Autor:
Wouters Walter Boudewijn Leopo, Alfons H. M. Raeymaekers, Ann Dillen, Jacky Van Dun, Marc Gaston Venet, Jozef H L Van Gelder, Roland De Coster, Eddy Jean Edgard Freyne, Marcel August Constant Janssen, M. D. W. G. Krekels, Gerard Charles Sanz
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 37:1049-1054
R76713 (6-[4-chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl]-1-methyl-1H-benzotriazole) is a selective, non-steroidal aromatase inhibitor containing an asymmetric carbon atom. In this paper, we compare the effects of R76713 (racemate) with its enantiomer
Publikováno v:
Steroids. 55:69-73
Reaction kinetics of the aromatase enzyme and of a new nonsteroidal aromatase inhibitor, R 76 713 (6-[(4-chlorophenyl)(1H-1,2,4-triazol-1-yl)-methyl]-1-methyl-1H- benzotriazole), were studied in ovarian homogenates obtained from pregnant mare's serum
Autor:
Wouters Walter Boudewijn Leopo, M. D. W. G. Krekels, Robert Van Ginckel, Jacco Zimmerman, M.-C. Coene, Carl Van Hove, W. Cools, Boudewijn Janssens
Publikováno v:
The Prostate. 29(1)
We studied the enzymatic characteristics of the oxidative catabolism of retinoic acid (RA) and its inhibition by liarozole-fumarate in homogenates of rat Dunning R3327G prostate tumors. Homogenates of rat liver were used as reference material. Both t
Autor:
Charlie Bowden, Roland De Coster, M. D. W. G. Krekels, Robert Van Ginckel, Wouters Walter Boudewijn Leopo
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 44(4-6)
Vorozole (R83842) is a potent and selective, non-steroidal aromatase inhibitor. It is the dextro-enantiomer of the triazole derivative R 76,713. In FSH-stimulated rat granulosa cells, vorozole inhibited aromatase activity with an IC50-value of 1.4 +/
Autor:
M. D. W. G. Krekels, R. Van Ginckel, M.-C. Coene, David W. End, R. De Coster, W. Wouters, Charlie Bowden
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 43(1-3)
Liarozole reduced tumor growth in the androgen-dependent Dunning-G and the androgen-independent Dunning MatLu rat prostate carcinoma models as well as in patients with metastatic prostate cancer who had relapsed after orchiectomy. In vitro , liarozol
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 38(4)
The aromatase enzyme and its inhibition by R 76 713 were characterized in the JEG-3 choriocarcinoma cell line in culture and in JEG-3 tumors grown in nude mice. Optimal cell culture parameters and enzyme reaction conditions for the determination of a
Autor:
C. Haelterman, R. Doolaege, D. Beerens, R. De Coster, N. Goeminne, W. Wouters, M. D. W. G. Krekels
Publikováno v:
Journal of veterinary pharmacology and therapeutics. 11(4)
The effects, of etomidate and of its fluoro analogue, R 8110, on adrenal, testicular and ovarian steroid biosynthesis were compared using cultures of guinea-pig adrenal, rat adrenal capsular, rat testicular and rat ovarian granulosa cells. At a conce
Autor:
A. Raeymaekers, M. D. W. G. Krekels, Eddy Jean Edgard Freyne, J. Van Gelder, M. Venet, D. Beerens, R. De Coster, P. A. J. Janssen, W. Wouters, C. Haelterman, J. van Dun
Publikováno v:
Journal of steroid biochemistry. 32(6)
The effects of R 76713, a new triazole derivative, on rat ovarian, testicular and adrenal steroidogenesis were investigated both in vitro and in vivo. In vitro R 76713 is a very potent inhibitor of the aromatase enzyme in rat granulosa cells, showing