Výsledky vyhledávání - "M. D. Vincent"

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Phase I study of concurrent and consolidation cisplatin and docetaxel chemotherapy with thoracic radiotherapy in non-small cell lung cancer

Autor: T W, Zhang, G B, Rodrigues, A V, Louie, D, Palma, A R, Dar, B, Dingle, W, Kocha, M, Sanatani, B, Yaremko, E, Yu, J, Younus, M D, Vincent

Publikováno v: Current oncology (Toronto, Ont.). 25(1)

We designed a phase i study of concurrent chemoradiotherapy (ccrt) with docetaxel (D) and cisplatin (C), followed by consolidation dc, for unresectable stage iii non-small cell lung cancer (nsclc).Patients with histologically proven and unresectable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::152e90614f8247a38dec4cbd852e3fe4
https://pubmed.ncbi.nlm.nih.gov/29507480

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Development and validation of a prediction index for hand-foot skin reaction in cancer patients receiving sorafenib

Autor: F. Fang, L. Huang, J. Yu, M. D. Vincent, George Dranitsaris, Mario E. Lacouture

Publikováno v: Annals of Oncology

Background This study describes a repeated measures prediction index to identify patients at high risk of ≥ grade 2 hand-foot skin reaction (HFSR) before each week of sorafenib therapy. Methods Data from 451 patients who received a sorafenib (400 m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d46492deb4a5ac6cfb594c6fe07c6e1
http://europepmc.org/articles/PMC3403729

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Enhancement of platinum-drug cytotoxicity in a human head and neck squamous cell carcinoma line and its platinum-resistant variant by liposomal amphotericin B and phospholipase A2-II

Autor: P J, Ferguson, C, Currie, M D, Vincent

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 27(12)

Platinum drugs comprise one of the main classes of chemotherapy drugs that can induce remissions in various solid tumors. Although tumors often regress on treatment with cis-diamminedichloroplatinum II (cisplatin) or cis-diammine-1,1-cyclobutane dica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4ec9e3ae5e50aaaa48271f9cc77b7869
https://pubmed.ncbi.nlm.nih.gov/10570020

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Antisense down-regulation of thymidylate synthase to suppress growth and enhance cytotoxicity of 5-FUdR, 5-FU and Tomudex in HeLa cells

Autor: P J, Ferguson, O, Collins, N M, Dean, J, DeMoor, C S, Li, M D, Vincent, J, Koropatnick

Publikováno v: British journal of pharmacology. 127(8)

1. Thymidylate synthase (TS), the key enzyme in de novo synthesis of thymidine, is an important target for antitumour chemotherapy. It was hypothesized that antisense oligonucleotide down-regulation of TS mRNA would decrease TS levels and enhance the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dd9cc749a656e24f4ef886b9df4c1156
https://pubmed.ncbi.nlm.nih.gov/10482907

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Subgroup analysis of a phase III trial of doxorubicin vs doxorubicin plus tesmilifene in advanced breast cancer (ABC): Tesmilifene survival benefit focused on patients with more aggressive disease

Autor: M. D. Vincent, H. Chen, Kathleen I. Pritchard, P. Keane

Publikováno v: Journal of Clinical Oncology. 23:756-756

756 Background: Tesmilifene (DPPE), a novel chemopotentiating small molecule, conferred a substantial (50%+) increase in median survival in MA.19, a 305 patient randomized trial in ABC (doxorubicin...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17d2c7fbc7af668b3d901a772f430b77
https://doi.org/10.1200/jco.2005.23.16_suppl.756

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Prognostic factors in small cell lung cancer: A simple prognostic index is better than conventional staging

Autor: Ian E. Smith, M. D. Vincent, Sue Ashley

Publikováno v: European Journal of Cancer and Clinical Oncology. 23:1589-1599

Conventional staging in small cell lung cancer (SCLC) is only of limited prognostic value and is often based on elaborate investigations. We have carried out univariate and multivariate analysis of possible prognostic factors at presentation in 333 c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80722d5a2df421ad5b9e2ff75df4319c
https://doi.org/10.1016/0277-5379(87)90436-6

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Carboplatin (Paraplatin; JM8) and etoposide (VP-16) as first-line combination therapy for small-cell lung cancer

Autor: B D Evans, John Yarnold, I.E. Smith, M E Gore, H. T. Ford, L. Repetto, M D Vincent

Publikováno v: Journal of Clinical Oncology. 5:185-189

Fifty-two previously untreated patients with small-cell lung carcinoma (SCLC) were treated with a combination of carboplatin 300 mg/m2 intravenously (IV) on day 1 and etoposide 100 mg/m2 IV on days 1 through 3 every 28 days for four courses. Patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36984b85a46b9299060b7a0b74a40ef9
https://doi.org/10.1200/jco.1987.5.2.185

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An analysis of possible prognostic features of long term and short term survivors of metastatic breast cancer

Autor: R. Skeet, Stanley W. Ashley, R. C. Coombes, S. Clarke, T. J. Powles, H. Adcock, M. D. Vincent, J. Gibb, H.L. Thomas

Publikováno v: European Journal of Cancer and Clinical Oncology. 22:1059-1065

Factors influencing the extremes of survival in disseminated breast cancer were analysed. From a pool of 1066 patients with distant metastatic breast cancer, the 41 patients who had survived 5 yr or more from first distant recurrence were matched wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db580b964730dc180e907d8c4486fb85
https://doi.org/10.1016/0277-5379(86)90006-4

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