Zobrazeno 1 - 10
of 29
pro vyhledávání: '"M. D. Tricklebank"'
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 355:361-364
Loxapine (0.3 mg/kg s.c.), olanzapine (10 mg/kg s.c.) and SCH 23390 (R-(+)-chloro-2, 3, 4, 5-tetrahydro-3-methyl-5-phenyl-1-H-3-benzazepine; 1 mg/kg, s.c.), but not clozapine (10 mg/kg, s.c.), induced catalepsy in rats. Co-administration of clozapine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be08e0ea734daa57246b86198d8a8d3e
https://doi.org/10.1007/pl00004955
https://doi.org/10.1007/pl00004955
Autor:
M D, Tricklebank
Pharmacological validation of novel functions for the alpha2A-, alpha2B-, and alpha2C-adrenoceptor (AR) subtypes has been hampered by the limited specificity and subtype-selectivity of available ligands. The current study describes a novel highly sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6cdeb8c789626edf586d96a915909eed
https://europepmc.org/articles/PMC2189729/
https://europepmc.org/articles/PMC2189729/
Autor:
M D, Tricklebank
Publikováno v:
IDrugs : the investigational drugs journal. 3(2)
Knoll is developing belaperidone, an antipsychotic agent, as a potential new treatment for schizophrenia. Phase II trials have commenced in Germany [200089,333710]. The compound is regarded as an atypical antipsychotic, similar in profile to clozapin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::692d11b24a7f3b555d49d4a6b42234f4
https://pubmed.ncbi.nlm.nih.gov/16107943
https://pubmed.ncbi.nlm.nih.gov/16107943
Publikováno v:
Behavioural pharmacology. 14(5-6)
The non-competitive NMDA receptor antagonist phencyclidine (PCP) is known to produce a discriminative stimulus in rats. The first aim of the present study was to investigate which NMDA receptor subtype(s) is involved in this effect of PCP. Rats were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dbff392a1e33705e393f08b7147386ba
https://pubmed.ncbi.nlm.nih.gov/14501261
https://pubmed.ncbi.nlm.nih.gov/14501261
Publikováno v:
Behavioural pharmacology. 9(8)
The interoceptive stimulus induced by clozapine (5 mg/kg, i.p.) has been characterized in an operant drug discrimination procedure in the rat using a wide range of receptor subtype-selective agonists and antagonists. Only the muscarinic receptor anta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0036223e5ddf200c9e1d1a69cfbd35b2
https://pubmed.ncbi.nlm.nih.gov/9890260
https://pubmed.ncbi.nlm.nih.gov/9890260
Autor:
M D Tricklebank
Publikováno v:
British Journal of Pharmacology. 150:381-382
The discovery of JP-1302 as a selective, high affinity antagonist at the alpha2C-adrenoceptor will enable researchers to probe the functional role and address the therapeutic utility of this potentially highly important adrenoceptor subtype.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c743f671e28e2c3b5b064f2b29abb252
https://doi.org/10.1038/sj.bjp.0707007
https://doi.org/10.1038/sj.bjp.0707007
Publikováno v:
British journal of pharmacology. 124(7)
1. The mechanism underlying the anticataleptic properties of the atypical neuroleptic agent, clozapine, has been investigated in the rat. 2.The close structural analogues of clozapine, loxapine (0.1 mg kg(-1) s.c.) and iso-clozapine (1 and 3 mg kg(-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::201827c30cd67866f66cfa9734df2b92
https://pubmed.ncbi.nlm.nih.gov/9723970
https://pubmed.ncbi.nlm.nih.gov/9723970
Autor:
L J, Bristow, P H, Hutson, J J, Kulagowski, P D, Leeson, S, Matheson, F, Murray, D, Rathbone, K L, Saywell, L, Thorn, A P, Watt, M D, Tricklebank
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 279(2)
The anticonvulsant and behavioral profile of the glycine/N-methyl-D-aspartate receptor antagonist L-701,324 [7-chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(H)quinolone] has been examined in rodents. In mice, L-701,324 protected against seizures induced by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c57825b32f07facff01ee00fd6b06d0a
https://pubmed.ncbi.nlm.nih.gov/8930150
https://pubmed.ncbi.nlm.nih.gov/8930150
Autor:
L J, Bristow, K L, Flatman, P H, Hutson, J J, Kulagowski, P D, Leeson, L, Young, M D, Tricklebank
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 277(2)
The present study has examined the glycine/N-methyl-D-aspartate antagonist, L-701-324 [7-chloro-4-hydroxy-3-(3-phenoxy)-phenyl-2 (H)quinolone] in rodent behavioral tests commonly used to predict antipsychotic potential and side effect liability in hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2ac7aa497a68c4961cdbf7895306d422
https://pubmed.ncbi.nlm.nih.gov/8627534
https://pubmed.ncbi.nlm.nih.gov/8627534
Publikováno v:
Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques. 38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::44ba37f621de65d2345831dc22e0adb0
https://pubmed.ncbi.nlm.nih.gov/1351689
https://pubmed.ncbi.nlm.nih.gov/1351689