Zobrazeno 1 - 10
of 20
pro vyhledávání: '"M. D. McKirnan"'
Publikováno v:
Journal of Applied Physiology. 86:93-100
Increased ventilation-perfusion (V˙a/Q˙) inequality is observed in ∼50% of humans during heavy exercise and contributes to the widening of the alveolar-arterial O2 difference (A-[Formula: see text]). Despite extensive investigation, the cause rem
Autor:
Judith A. Wisneski, M. D. McKirnan, Francis C. White, Michael Weiner, Saul Schaefer, Gregory G. Schwartz, Joe G.N. Garcia, Barry M. Massie
Publikováno v:
Circulation. 91:1814-1823
Background Although left ventricular hypertrophy (LVH) is frequently associated with impaired coronary vasodilator reserve, it is uncertain whether this leads to myocardial ischemia under physiological conditions. The goal of the present study was to
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 266:R118-R124
This study examined the effect of dynamic exercise on vasopressin release in the miniswine and factors that may elicit this response (n = 15). Thus lysine vasopressin (LVP), the catecholamines epinephrine and norepinephrine (EPI and NE), plasma renin
Publikováno v:
Journal of Clinical Investigation. 92:2644-2652
Regional myocardial ischemia is associated with increased levels of adenosine and norepinephrine, factors that may alter activation of the beta-adrenergic receptor (beta AR)-G protein-adenylyl cyclase pathway in the heart. We have used the ameroid co
Publikováno v:
Journal of Applied Physiology. 70:1097-1104
Eight exercise-trained miniature swine were studied during prolonged treadmill runs (100 min) under fasting and preexercise feeding conditions. Each animal ran at identical external work loads that corresponded to 65% of the heart rate reserve (210-2
Publikováno v:
Molecular and cellular biochemistry. 176(1-2)
In the early stages of left ventricular hypertrophy (LVH) acute adaptive changes occur in the coronary vasculature as it remodels. Plasminogen activators (PAs) and inhibitors (PAIs) have the potential effects of proteolytic degradation that is releva
Publikováno v:
Circulatory shock. 44(4)
To determine the efficacy of low-volume resuscitation in dehydrated subjects, 7.5% hypertonic saline/6% dextran 70 (HSD) and lactated Ringer's (LR) treatments were compared in conscious pigs dehydrated for 48 hr prior to a 37% blood volume hemorrhage
Autor:
M D, McKirnan, C M, Bloor
Publikováno v:
Medicine and science in sports and exercise. 26(10)
Coronary vascular adaptations to exercise training have been extensively studied at the microscopic level in animals and correlated with direct and indirect measurements of myocardial blood flow in patients with coronary artery disease. Animals have
Publikováno v:
Medicine & Science in Sports & Exercise. 22:S84
Publikováno v:
Journal of Applied Physiology. 61:1226-1229
A respiratory mask was developed for resting and exercising swine. The lightweight, low-dead-space design fits airtight against the animals' snouts to provide breath-by-breath measurements of respiration and metabolism. Validation of the mask was car