Zobrazeno 1 - 10
of 14
pro vyhledávání: '"M. D. Bernardo"'
Autor:
Helena Edlund, Lisandro M. D. Bernardo, Lisa Lundberg, Fredrik Backlund, Claes-Göran Östenson, Pär Steneberg, Sara Edfalk
Publikováno v:
Diabetes
Genome-wide association studies have identified several type 2 diabetes (T2D) risk loci linked to impaired β-cell function. The identity and function of the causal genes in these susceptibility loci remain, however, elusive. The HHEX/IDE T2D locus i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb71988ad147cd8925ee27502020009
https://doi.org/10.2337/db12-1045
https://doi.org/10.2337/db12-1045
Publikováno v:
Journal of Biological Chemistry. 284:828-838
The sigma(54)-factor controls expression of a variety of genes in response to environmental cues. Much previous work has implicated the nucleotide alarmone ppGpp and its co-factor DksA in control of sigma(54)-dependent transcription in the gut commen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::479b9d714c0501dcd7cc93f1abe602ef
https://doi.org/10.1074/jbc.m807707200
https://doi.org/10.1074/jbc.m807707200
Autor:
Ewa Stec, Linda Johansson, Eleonore Skärfstad, Lisandro M. D. Bernardo, Kristoffer Brännström, Agnieszka Szalewska-Pałasz, Victoria Shingler
Publikováno v:
Journal of Biological Chemistry. 282:18046-18056
The bacterial nutritional and stress alarmone ppGpp and its co-factor DksA directly bind RNA polymerase to regulate its activity at certain σ70-dependent promoters. A number of promoters that are dependent on alternative σ-factors function poorly i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::667a5eb05672418f9cfc8e399e5d9c01
https://doi.org/10.1074/jbc.m610181200
https://doi.org/10.1074/jbc.m610181200
Autor:
Dafne Solera, Linda Johansson, Eleonore Skärfstad, Victoria Shingler, Lisandro M. D. Bernardo
Publikováno v:
Molecular Microbiology. 60:749-764
The RNA polymerase-binding protein DksA is a cofactor required for guanosine tetraphosphate (ppGpp)-responsive control of transcription from sigma70 promoters. Here we present evidence: (i) that both DksA and ppGpp are required for in vivo sigma54 tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c8ca1efee0fa59b56dd7bcde567ac8
https://doi.org/10.1111/j.1365-2958.2006.05129.x
https://doi.org/10.1111/j.1365-2958.2006.05129.x
Autor:
Chun Chau Sze, Agnieszka Szalewska-Pałasz, Eleonore Skärfstad, Lisandro M. D. Bernardo, Victoria Shingler, Andrew D. Laurie, Thomas Nyström
Publikováno v:
Journal of Biological Chemistry. 278:1494-1503
Some promoters, including the DmpR-controlled sigma(N)-dependent Po promoter, are effectively rendered silent in cells lacking the nutritional alarmone (p)ppGpp. Here we demonstrate that four mutations within the housekeeping sigma(D)-factor can rest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8727919441af27b48af0edf29bd4722a
https://doi.org/10.1074/jbc.m209268200
https://doi.org/10.1074/jbc.m209268200
Publikováno v:
Journal of Bacteriology. 184:760-770
Pseudomonas-derived regulators DmpR and XylR are structurally and mechanistically related σ54-dependent activators that control transcription of genes involved in catabolism of aromatic compounds. The binding of distinct sets of aromatic effectors t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2fd7b69179e43519aa8850198b67e78
https://doi.org/10.1128/jb.184.3.760-770.2002
https://doi.org/10.1128/jb.184.3.760-770.2002
Autor:
Peter Togneri, Eleonore Skärfstad, Lisandro M. D. Bernardo, Teresa del Peso-Santos, Linda Holmfeldt, Victoria Shingler
Publikováno v:
Nucleic Acids Research
The activities of promoters can be temporally and conditionally regulated by mechanisms other than classical DNA-binding repressors and activators. One example is the inherently weak σ(70)-dependent Pr promoter that ultimately controls catabolism of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6b77c55bcff215c73a99d7f5b783969
https://pubmed.ncbi.nlm.nih.gov/21447563
https://pubmed.ncbi.nlm.nih.gov/21447563
Publikováno v:
Molecular microbiology. 70(3)
Divergent transcription of a regulatory gene and a cognate promoter under its control is a common theme in bacterial regulatory circuits. This genetic organization is found for the dmpR gene that encodes the substrate-responsive specific regulator of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42300163b8fc721dfb2e2b4e2bd2c1b1
https://pubmed.ncbi.nlm.nih.gov/18786144
https://pubmed.ncbi.nlm.nih.gov/18786144
Autor:
Agnieszka, Szalewska-Palasz, Linda U M, Johansson, Lisandro M D, Bernardo, Eleonore, Skärfstad, Ewa, Stec, Kristoffer, Brännström, Victoria, Shingler
Publikováno v:
The Journal of biological chemistry. 282(25)
The bacterial nutritional and stress alarmone ppGpp and its co-factor DksA directly bind RNA polymerase to regulate its activity at certain sigma70-dependent promoters. A number of promoters that are dependent on alternative sigma-factors function po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::04e604b36c344e99c49bd8ded1430a78
https://pubmed.ncbi.nlm.nih.gov/17456470
https://pubmed.ncbi.nlm.nih.gov/17456470
Autor:
Lisandro M D, Bernardo, Linda U M, Johansson, Dafne, Solera, Eleonore, Skärfstad, Victoria, Shingler
Publikováno v:
Molecular microbiology. 60(3)
The RNA polymerase-binding protein DksA is a cofactor required for guanosine tetraphosphate (ppGpp)-responsive control of transcription from sigma70 promoters. Here we present evidence: (i) that both DksA and ppGpp are required for in vivo sigma54 tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::edfa7cb01a32e14a84fe02d2cffcb0a6
https://pubmed.ncbi.nlm.nih.gov/16629675
https://pubmed.ncbi.nlm.nih.gov/16629675