Zobrazeno 1 - 10
of 553
pro vyhledávání: '"M. D'alto"'
Exploiting bacterial effector proteins to uncover evolutionarily conserved antiviral host machinery.
Autor:
Aaron Embry, Nina S Baggett, David B Heisler, Addison White, Maarten F de Jong, Benjamin L Kocsis, Diana R Tomchick, Neal M Alto, Don B Gammon
Publikováno v:
PLoS Pathogens, Vol 20, Iss 5, p e1012010 (2024)
Arboviruses are a diverse group of insect-transmitted pathogens that pose global public health challenges. Identifying evolutionarily conserved host factors that combat arbovirus replication in disparate eukaryotic hosts is important as they may tip
Externí odkaz:
https://doaj.org/article/716bfb4c35654fca915a68f5ac229b2e
Autor:
Hang Yin, Jian Zheng, Qiuqiu He, Xuan Zhang, Xuzichao Li, Yongjian Ma, Xiao Liang, Jiaqi Gao, Benjamin L. Kocsis, Zhuang Li, Xiang Liu, Neal M. Alto, Long Li, Heng Zhang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
The multifunctional GSDMB protein is an important molecule in human immunity. Here, the authors decipher the molecular mechanisms of GSDMB targeting by the bacterial virulence factor IpaH7.8 and provide insights into GSDMB-mediated pyroptosis.
Externí odkaz:
https://doaj.org/article/8e58daca557945249ec7a6741dc9b609
Autor:
Nora-Guadalupe P. Ramirez, Jeon Lee, Yue Zheng, Lianbo Li, Bryce Dennis, Didi Chen, Ashwini Challa, Vicente Planelles, Kenneth D. Westover, Neal M. Alto, Iván D’Orso
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
By screening for host factors that influence HIV-1 proviral fate, the authors identified ADAP1 as a tuner of KRAS–ERK–AP-1 axis, which consequentially influences gene programs relevant for T cell activation and latent virus reactivation.
Externí odkaz:
https://doaj.org/article/533a78919ec24b05aadddaaaa2df40d0
Autor:
David B Heisler, Kristen A Johnson, Duo H Ma, Maikke B Ohlson, Lishu Zhang, Michelle Tran, Chase D Corley, Michael E Abrams, Jeffrey G McDonald, John W Schoggins, Neal M Alto, Arun Radhakrishnan
Publikováno v:
eLife, Vol 12 (2023)
Most of the cholesterol in the plasma membranes (PMs) of animal cells is sequestered through interactions with phospholipids and transmembrane domains of proteins. However, as cholesterol concentration rises above the PM’s sequestration capacity, a
Externí odkaz:
https://doaj.org/article/9ee693e99a52438f90f37dcabfa88589
Autor:
Nicholas Rinkenberger, Michael E Abrams, Sumit K Matta, John W Schoggins, Neal M Alto, L David Sibley
Publikováno v:
eLife, Vol 10 (2021)
Toxoplasma gondii is an important human pathogen infecting an estimated one in three people worldwide. The cytokine interferon gamma (IFNγ) is induced during infection and is critical for restricting T. gondii growth in human cells. Growth restricti
Externí odkaz:
https://doaj.org/article/f9a094b9feae4b0d9982f05ca988a55a
Autor:
Maarten De Jong, Neal M Alto
Publikováno v:
eLife, Vol 10 (2021)
The toxins that some bacteria secrete to kill off rival species can also generate mutations that help toxin-resistant populations adapt to new environments.
Externí odkaz:
https://doaj.org/article/9d6c1f572a644ad392d469cc5796c45f
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 12, Pp 1538- (2020)
Externí odkaz:
https://doaj.org/article/7d446369e8a1413f903e8ab66c6607d2
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Microbial pathogens secrete effector proteins into host cells to affect cellular functions. Here, the authors use a yeast-based screen to study around 200 effectors from six bacterial species, showing that over 30% of them interact with the eukaryoti
Externí odkaz:
https://doaj.org/article/217bfd32a26b4c0bb9b8f8ae3db9c3fe
Autor:
Chelsea E. Stamm, Breanna L. Pasko, Sujittra Chaisavaneeyakorn, Luis H. Franco, Vidhya R. Nair, Bethany A. Weigele, Neal M. Alto, Michael U. Shiloh
Publikováno v:
mSphere, Vol 4, Iss 3 (2019)
ABSTRACT Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, is one of the most successful human pathogens. One reason for its success is that Mtb can reside within host macrophages, a cell type that normally functions to phagocyto
Externí odkaz:
https://doaj.org/article/159f05ea47384c9c90842d3b47c3a1cf
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