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John O’Malley on Vatican II and Bernard Lonergan’s Realms of Meaning

Autor: Rohan M. Curnow

Publikováno v: Irish Theological Quarterly. 75:188-203

This article considers John O’Malley’s argument that the Second Vatican Council marks a break with the Catholic past. O’Malley contends that this discontinuity is most evident when one considers the nature of the genre of Vatican II’s documen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99b8d8e488ac9ccda7c6e61e019a9b31
https://doi.org/10.1177/0021140009344454

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A Compound Heterozygote Case of Type II Aldosterone Synthase Deficiency

Autor: J. Montalto, Kathleen M. Curnow, John W. Funder, Felicity M. Dunlop, Patricia Crock

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 88:2518-2526

An infant with failure to thrive, persistent hyponatremia and episodic vomiting and diarrhea was admitted to hospital at 9 months of age, and the diagnosis of type II aldosterone synthase deficiency was confirmed by plasma and urinary steroid determi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6067baee377566b1691b99f79dfd67
https://doi.org/10.1210/jc.2003-030353

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Deletion Hybrid Genes, due to Unequal Crossing Over betweenCYP11B1(11β-Hydroxylase) andCYP11B2(Aldosterone Synthase) Cause Steroid 11β-Hydroxylase Deficiency and Congenital Adrenal Hyperplasia1

Autor: Paolo Mulatero, Leigh Pascoe, Yves Morel, Kathleen M. Curnow, Stephanie Portrat, Jean-Louis Chaussain

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 86:3197-3201

Chromosomal rearrangements are natural experiments that can provide unique insights into in vivo regulation of genes and physiological systems. We have studied a patient with congenital adrenal hyperplasia and steroid 11beta-hydroxylase deficiency wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7bd13efb3a182c7afe26db0dd79f51c
https://doi.org/10.1210/jcem.86.7.7671

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Autor: Brian S. Nunez, Perrin C. White, Kathleen M. Curnow, D. Randy McMillan, Heli Nikkila, Leigh Pascoe

Publikováno v: Molecular Endocrinology. 14:1351-1364

cDNA clones encoding a novel putative G protein-coupled receptor have been characterized. The receptor is widely expressed in normal solid tissues. Consisting of 1967 amino acid residues, this receptor is one of the largest known and is therefore ref

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::047abd441b5dcc112c8f7471a0926536
https://doi.org/10.1210/mend.14.9.0511

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Isolated Aldosterone Synthase Deficiency Caused by Simultaneous E198D and V386A Mutations in the CYP11B2 Gene1

Autor: Kathleen M. Curnow, Yves Morel, J. Tourniaire, S. Portrat-Doyen, Leigh Pascoe, O. Richard, Paolo Mulatero, B. Aupetit-Faisant

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 83:4156-4161

Isolated deficiencies in aldosterone biosynthesis are caused by mutations in the CYP11B2 (aldosterone synthase) gene. Patients with this deficiency have impaired aldosterone synthesis, exhibit increased plasma renin activity, secrete increased amount

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4cae4fec9914132f7524f21179e1b1ea
https://doi.org/10.1210/jcem.83.11.5258

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RecombinantCYP11BGenes Encode Enzymes that Can Catalyze Conversion of 11-Deoxycortisol to Cortisol, 18-Hydroxycortisol, and 18-Oxocortisol1

Autor: Kathleen M. Curnow, Leigh Pascoe, Pierre Corvol, Xavier Jeunemaitre, Paolo Mulatero, B. Aupetit-Faisant, Celso E. Gomez-Sanchez, Franco Veglio, M. Foekling

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 83:3996-4001

CYP11B1 (11beta-hydroxylase) and CYP11B2 (aldosterone synthase) are 93% identical mitochondrial enzymes that both catalyze 11beta-hydroxylation of steroid hormones. CYP11B2 has the additional 18-hydroxylase and 18-oxidase activities required for conv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0fdbde5ac4e69d53d277f6f2c66b6e72
https://doi.org/10.1210/jcem.83.11.5237

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Proceedings of the Symposium ‘Angiotensin AT1 Receptors: From Molecular Physiology to Therapeutics’: HUMAN TYPE-1 ANGIOTENSIN II (AT1) RECEPTOR GENE STRUCTURE AND FUNCTION

Autor: Kathleen M. Curnow

Publikováno v: Clinical and Experimental Pharmacology and Physiology. 23:67-73

1. The type-1 angiotensin II (AngII) receptors, designated AT(1), mediate most of the biological actions of the peptide hormone AngII. They are the most recent drug target for the treatment of hypertension and cardiac failure and basic research is no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3661a076efffa4d595ec8884f35d620e
https://doi.org/10.1111/j.1440-1681.1996.tb02816.x

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