Zobrazeno 1 - 2
of 2
pro vyhledávání: '"M. Cristina Vinci"'
Autor:
Daniela N. Petrusca, Zhoumo Chen, Timothy M. Doyle, Irina Petrache, Daniela Salvemini, Emanuela Mazzon, Emanuela Masini, Emanuela Esposito, Salvatore Cuzzocrea, Leesa Bryant, M. Cristina Vinci
Publikováno v:
Neuroscience Letters. 463:49-53
Opiates, like morphine, are the most effective analgesics for treating acute and chronic severe pain, but their use is limited by the development of analgesic tolerance and hypersensitivity to innocuous and noxious stimuli. Because opioids are a main
Autor:
Vincenzo Mollace, Emanuela Esposito, George M. Matuschak, Carolina Muscoli, Daniela N. Petrusca, Irina Petrache, M. Cristina Vinci, Salvatore Cuzzocrea, Emanuela Masini, Dechun Li, Emanuela Mazzon, Daniela Salvemini, Michael M. Ndengele
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 329:64-75
The effective treatment of pain is typically limited by a decrease in the pain-relieving action of morphine that follows its chronic administration (tolerance). Therefore, restoring opioid efficacy is of great clinical importance. In a murine model o