In the quest for the elusive gamma-helix: homo-oligomers from 2-aminoadamantane-2-carboxylic acid

Autor: M. Crisma

Publikováno v: 15th Naples Workshop on Bioactive Peptides, Napoli, 23-25/06/2016
info:cnr-pdr/source/autori:M. Crisma/congresso_nome:15th Naples Workshop on Bioactive Peptides/congresso_luogo:Napoli/congresso_data:23-25%2F06%2F2016/anno:2016/pagina_da:/pagina_a:/intervallo_pagine

gamma-Turns (also termed C7 forms) are pseudo-cyclic structures that are stabilized by an intramolecular H-bond between the N(3)-H(3) and O(1)=C(1) groups. A series of contiguous gamma-turns generates a gamma- [or 2.2(7)-] helix. Such helical conform

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::c5124ab9ccc1be764b2570d0efc2a60b
http://www.cnr.it/prodotto/i/356977

Total Synthesis of Retro-Peptide Oligomers

Autor: S. Ceretti, S. De Pol, F. Formaggio, M. Crisma, C. Toniolo, LUPPI, GIANLUIGI, TOMASINI, CLAUDIA

The total synthesis of sequential oligomers of the retro peptides having the general formula Boc-(gGly-mAib)n-OBn has been carried out starting from dimethyl malonic acid in good overall yield. The key step is the formation of the gGly unit, which is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4094::4480ab9dd1ae0577f742bbe25113bece
http://hdl.handle.net/11585/18763

Multiple, consecutive, fully-extended 2.0(5)-helix peptide conformation

Autor: C. Peggion, A. Moretto, F. Formaggio, M. Crisma, C. Toniolo

Publikováno v: Biopolymers (Online) 100 (2013): 621–636. doi:10.1002/bip.22267
info:cnr-pdr/source/autori:C. Peggion, A. Moretto, F. Formaggio, M. Crisma, C. Toniolo/titolo:Multiple, consecutive, fully-extended 2.0(5)-helix peptide conformation/doi:10.1002%2Fbip.22267/rivista:Biopolymers (Online)/anno:2013/pagina_da:621/pagina_a:636/intervallo_pagine:621–636/volume:100

The peptide 2.0(5)-helix does exist. It has been experimentally authenticated both in the crystalline state (by X-ray diffraction) and in solution (by several spectroscopic techniques). It is the most common conformation for C-alpha-tetrasubstituted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::0ca651fd501b4b92469066214d0dd3d5
https://publications.cnr.it/doc/271857

Ac10c: A medium-ring, cycloaliphatic Cα,α-disubstituted glycine. Incorporation into model peptides and preferred conformation

Autor: A. Moretto, F. Formaggio, M. Crisma, C. Toniolo, M. Saviano, R. M. Vitale, E. Benedetti, IACOVINO, Rosa

Two complete series of N-protected oligopeptide esters to the pentamer level from 1-amino-cyclodecane-1-carboxylic acid (AC10C), an α-amino acid conformationally constrained through a medium-ring Ciα↔Ciα cyclization, and either the L-Ala or Aib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3977::c734cbb02ad4b03c65b20394be015ba4
http://hdl.handle.net/11591/185475

On the conformational preference of fully-thioamidated homo-alpha-peptides

Autor: F. Formaggio, S. Bresolin, M. Crisma, C. Toniolo, C. Peggion

Publikováno v: COST Action CM0803 Workshop "Foldamers: Synthesis and Structure of Functional Materials", Regensburg, Germany, 30 agosto-2 settembre 2012
info:cnr-pdr/source/autori:F. Formaggio; S. Bresolin; M. Crisma; C. Toniolo; C. Peggion/congresso_nome:COST Action CM0803 Workshop "Foldamers: Synthesis and Structure of Functional Materials"/congresso_luogo:Regensburg, Germany/congresso_data:30 agosto-2 settembre 2012/anno:2012/pagina_da:/pagina_a:/intervallo_pagine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::ccb4ab54dd4ca5364feb2bde1ae95eaf
http://www.cnr.it/prodotto/i/192966