Zobrazeno 1 - 10
of 29
pro vyhledávání: '"M. Comley"'
Autor:
Helen Turley, M. Comley, S Houlbrook, Akihiko Kikuchi, N. Nozaki, Al Harris, Ian D. Hickson, K C Gatter
Publikováno v:
Scopus-Elsevier
British Journal of Cancer
British Journal of Cancer
In mammalian cells, there are two isoforms of DNA topoisomerase II, designated alpha (170-kDa form) and beta (180-kDa form). Previous studies using cell lines have shown that the topoisomerase IIalpha and beta isoforms are differentially regulated du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b76b641d0512d6f76ecb0ac7421a243
https://doi.org/10.1038/bjc.1997.227
https://doi.org/10.1038/bjc.1997.227
Autor:
Al Harris, Mark Westwood, Stephen B. Fox, Helen Turley, K C Gatter, R. M. Whitehouse, Roy Bicknell, M. Comley, Amir Moghaddam
Publikováno v:
British Journal of Cancer
Scopus-Elsevier
Scopus-Elsevier
Tumour angiogenesis is a complex multistep process regulated by a number of angiogenic factors. One such factor, platelet-derived endothelial cell growth factor has recently been shown to be thymidine phosphorylase (TP). TP catalyses the reversible p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f720d777bcff48f66e3c965fea6e9b0
http://europepmc.org/articles/PMC2074437
http://europepmc.org/articles/PMC2074437
Autor:
R. M. Whitehouse, Helen Turley, Kevin C. Gatter, M. Comley, Stephen B. Fox, Adrian L. Harris, K. Engels
Publikováno v:
Annals of oncology : official journal of the European Society for Medical Oncology. 8(3)
Summary Background Thymidine phosphorylase (TP) catalyses the reversible phosphorylation of thymidine to thymine and 2-deoxyribose-1-phosphate. High expression of TP in cell lines potentiates the effects of the cytotoxic drugs 5-fluorouracil and meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d060fb536fc0beec73204a7bf89940
https://pubmed.ncbi.nlm.nih.gov/9137797
https://pubmed.ncbi.nlm.nih.gov/9137797
Autor:
A, Giatromanolaki, M I, Koukourakis, M, Comley, L, Kaklamanis, H, Turley, K, O'Byrne, A L, Harris, K C, Gatter
Publikováno v:
The Journal of pathology. 181(2)
Platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP) is an enzyme with angiogenic and cell motility properties. Moreover, it is involved in the transformation of fluoropyrimidines into active cytotoxic metabolites. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f30d64a8bd9c554d44a0bd29c74c2f98
https://pubmed.ncbi.nlm.nih.gov/9120725
https://pubmed.ncbi.nlm.nih.gov/9120725
Autor:
Helen Turley, Albert C.M. Ong, Runjan Chetty, K Gattner, Peter J. Ratcliffe, Peter C. Harris, S Biddolph, Christopher J. Ward, M Comley
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 93(4)
Polycystic kidney disease 1 (PKD1) is the major locus of the common genetic disorder autosomal dominant polycystic kidney disease. We have studied PKD1 mRNA, with an RNase protection assay, and found widespread expression in adult tissue, with high l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbdaa1befefc7da75ec8d60b9faf565b
https://pubmed.ncbi.nlm.nih.gov/8643665
https://pubmed.ncbi.nlm.nih.gov/8643665
Autor:
H, Turley, F, Pezzella, S, Kocialkowski, M, Comley, L, Kaklamanis, J, Fawcett, D, Simmons, A L, Harris, K C, Gatter
Publikováno v:
Cancer research. 55(23)
A gene called deleted in colon cancer (DCC) has been identified on a region of chromosome 18, which is deleted in 70% of colorectal cancers. The DCC gene encodes a protein belonging to the immunoglobulin superfamily with similarity to the N-CAM trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6adc3642cd3a3c8e53721f5705e1b214
https://pubmed.ncbi.nlm.nih.gov/7585645
https://pubmed.ncbi.nlm.nih.gov/7585645
Publikováno v:
Journal of clinical pathology. 48(11)
AIM--To establish the role of immunohistochemistry (using a limited panel of antibodies) in detecting minimal involvement by follicular lymphoma in routinely processed bone marrow trephine specimens, which show no obvious morphological (light microsc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a34f10a1544541a7a6dd1db3364466
https://pubmed.ncbi.nlm.nih.gov/9059369
https://pubmed.ncbi.nlm.nih.gov/9059369
Autor:
W. C. E. Higginson, H. M. Comley
Publikováno v:
Chemischer Informationsdienst. 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7e4958ed9d26c47a2aff4df98a25a63
https://doi.org/10.1002/chin.197306373
https://doi.org/10.1002/chin.197306373
Autor:
Helen Turley, C H Boshoff, Runjan Chetty, M.A. Dada, M Comley, Johann W. Schneider, K C Gatter
Publikováno v:
Scopus-Elsevier
AIMS: To examine the immunohistochemical distribution of thymidine phosphorylase (TP) in all clinicopathological subtypes of Kaposi sarcoma. METHODS: Thirty two biopsy specimens of Kaposi sarcoma (29 patients) were studied. Six of these patients repr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6033bec2c3a07833862ce4a895674670
http://www.scopus.com/inward/record.url?eid=2-s2.0-0030049368&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-0030049368&partnerID=MN8TOARS
Autor:
W. C. E. Higginson, H. M. Comley
Publikováno v:
Journal of the Chemical Society, Dalton Transactions. :2522
The pH-dependence of the rate of loss of chloride ion from cis-chlorobis(ethylenediamine)glycinato-N-cobalt(III) indicates weak SN2 character involving participation of the free carboxylate group of the unidentate glycinato-ligand. Weakly basic anion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4fd0bce8cefb99d9e0a5c11f00c8904
https://doi.org/10.1039/dt9720002522
https://doi.org/10.1039/dt9720002522