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Akademický článek

Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting

Publikováno v: npj Precision Oncology, Vol 8, Iss 1, Pp 1-14 (2024)

Abstract Homologous recombination (HR) and nucleotide excision repair (NER) are the two most frequently disabled DNA repair pathways in cancer. HR-deficient breast, ovarian, pancreatic and prostate cancers respond well to platinum chemotherapy and PA

Externí odkaz: https://doaj.org/article/b6b069037e684be89e6db272774fcef6

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Akademický článek

Kir4.1 channels contribute to astrocyte CO2/H+-sensitivity and the drive to breathe

Autor: Colin M. Cleary, Jack L. Browning, Moritz Armbruster, Cleyton R. Sobrinho, Monica L. Strain, Sarvin Jahanbani, Jaseph Soto-Perez, Virginia E. Hawkins, Chris G. Dulla, Michelle L. Olsen, Daniel K. Mulkey

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)

Abstract Astrocytes in the retrotrapezoid nucleus (RTN) stimulate breathing in response to CO2/H+, however, it is not clear how these cells detect changes in CO2/H+. Considering Kir4.1/5.1 channels are CO2/H+-sensitive and important for several astro

Externí odkaz: https://doaj.org/article/1f960e43c3b940399d7ba13f775dde08

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Akademický článek

Phox2b-expressing neurons contribute to breathing problems in Kcnq2 loss- and gain-of-function encephalopathy models

Autor: J. Soto-Perez, C. M. Cleary, C. R. Sobrinho, S. B. Mulkey, J. L. Carroll, A. V. Tzingounis, D. K. Mulkey

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Abstract Loss- and gain-of-function variants in the gene encoding KCNQ2 channels are a common cause of developmental and epileptic encephalopathy, a condition characterized by seizures, developmental delays, breathing problems, and early mortality. T

Externí odkaz: https://doaj.org/article/d561153d7af04b878cae1cdf1c996f51

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Akademický článek

Interface-acting nucleotide controls polymerization dynamics at microtubule plus- and minus-ends

Autor: Lauren A McCormick, Joseph M Cleary, William O Hancock, Luke M Rice

Publikováno v: eLife, Vol 12 (2024)

GTP-tubulin is preferentially incorporated at growing microtubule ends, but the biochemical mechanism by which the bound nucleotide regulates the strength of tubulin:tubulin interactions is debated. The ‘self-acting’ (cis) model posits that the n

Externí odkaz: https://doaj.org/article/68fe5f499f9a438da74d307b30dd5768

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Akademický článek

Cabozantinib plus atezolizumab in previously untreated advanced hepatocellular carcinoma and previously treated gastric cancer and gastroesophageal junction adenocarcinoma: results from two expansion cohorts of a multicentre, open-label, phase 1b trial (COSMIC-021)Research in context

Autor: Daneng Li, Yohann Loriot, Adam M. Burgoyne, James M. Cleary, Armando Santoro, Daniel Lin, Santiago Ponce Aix, Ignacio Garrido-Laguna, Ramu Sudhagoni, Xiang Guo, Svetlana Andrianova, Scott Paulson

Publikováno v: EClinicalMedicine, Vol 67, Iss , Pp 102376- (2024)

Summary: Background: Cabozantinib is approved for previously treated advanced hepatocellular carcinoma (aHCC) and has been investigated in gastric cancer (GC) and gastroesophageal junction adenocarcinoma (GEJ). Atezolizumab plus bevacizumab is approv

Externí odkaz: https://doaj.org/article/4755d3d913804c63b46661b4dce5ecba

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Akademický článek

RETRACTED ARTICLE: Polymerase θ inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in models of BRCA-deficient cancer

Autor: Jeffrey Patterson-Fortin, Heta Jadhav, Constantia Pantelidou, Tin Phan, Carter Grochala, Anita K. Mehta, Jennifer L. Guerriero, Gerburg M. Wulf, Brian M. Wolpin, Ben Z. Stanger, Andrew J. Aguirre, James M. Cleary, Alan D. D’Andrea, Geoffrey I. Shapiro

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Abstract Recently developed inhibitors of polymerase theta (POLθ) have demonstrated synthetic lethality in BRCA-deficient tumor models. To examine the contribution of the immune microenvironment to antitumor efficacy, we characterized the effects of

Externí odkaz: https://doaj.org/article/1a29347110de4ea98e7dbf7d5ea3b928

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