Zobrazeno 1 - 10
of 273
pro vyhledávání: '"M. Chudakov"'
Autor:
E. L. Nasonov, V. I. Mazurov, A. M. Lila, T. V. Dubinina, I. Z. Gaydukova, S. A. Lapshina, A. A. Klimenko, D. V. Somov, S. A. Lukianov, D. M. Chudakov, I. V. Zvyagin, O. V. Britanova, M. A. Korolev, D. I. Abdulganieva, D. G. Krechikova, A. A. Kastanayan, L. V. Eliseeva, R. R. Samigullina, T. V. Povarova, O. V. Antipova, S. A. Smakotina, V. N. Soboleva, O. B. Nesmeyanova, T. V. Plaksina, N. F. Soroka, I. B. Vinogradova, A. P. Rebrov, T. V. Kropotina, A. L. Maslyanskiy, A. V. Zinkina-Orikhan, Yu. N. Lin’kova, P. S. Pukhtinskaia, M. A. Morozova, G. A. Vinderskaya
Publikováno v:
Научно-практическая ревматология, Vol 62, Iss 1, Pp 65-80 (2024)
The aim – to evaluate the clinical effectiveness, safety, pharmacokinetics, pharmacodynamics, and immunogenicity of seniprutug (BCD-180) in patients with radiographic active axial spondyloarthritis (r-axSpA, or ankylosing spondylitis).Subjects and
Externí odkaz:
https://doaj.org/article/38cd433e63d04c6c9e4e85e988370a30
Autor:
Anastasiia Tsareva, Pavel V. Shelyakin, Irina A. Shagina, Mikhail Yu. Myshkin, Ekaterina M. Merzlyak, Valeriia V. Kriukova, Alexander S. Apt, Irina A. Linge, Dmitriy M. Chudakov, Olga V. Britanova
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Mycobacterium tuberculosis (Mtb) remains a major threat worldwide, although only a fraction of infected individuals develops tuberculosis (TB). TB susceptibility is shaped by multiple genetic factors, and we performed comparative immunological analys
Externí odkaz:
https://doaj.org/article/21bbd6e3c48540329f6d1feed125b949
Convergence, plasticity, and tissue residence of regulatory T cell response via TCR repertoire prism
Autor:
Tatyana O Nakonechnaya, Bruno Moltedo, Ekaterina V Putintseva, Sofya Leyn, Dmitry A Bolotin, Olga V Britanova, Mikhail Shugay, Dmitriy M Chudakov
Publikováno v:
eLife, Vol 12 (2024)
Suppressive function of regulatory T cells (Treg) is dependent on signaling of their antigen receptors triggered by cognate self, dietary, or microbial peptides presented on MHC II. However, it remains largely unknown whether distinct or shared reper
Externí odkaz:
https://doaj.org/article/62a2acd1ab584584af575e33ae102adc
Autor:
Saveliy A. Sheetikov, Alexandra A. Khmelevskaya, Ksenia V. Zornikova, Ivan V. Zvyagin, Alina S. Shomuradova, Yana V. Serdyuk, Naina T. Shakirova, Iuliia O. Peshkova, Aleksei Titov, Dmitrii S. Romaniuk, Irina A. Shagina, Dmitry M. Chudakov, Dmitry O. Kiryukhin, Olga V. Shcherbakova, Ekaterina G. Khamaganova, Vitalina Dzutseva, Andrei Afanasiev, Apollinariya V. Bogolyubova, Grigory A. Efimov
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Adenovirus vaccines, particularly the COVID-19 Ad5-nCoV adenovirus vaccine, have emerged as promising tools in the fight against infectious diseases. In this study, we investigated the structure of the T cell response to the Spike protein of the SARS
Externí odkaz:
https://doaj.org/article/c8dda62480a240ed83d72a7ba8d1b3ca
Autor:
M. O. Ustiuzhanina, Ju. D. Vavilova, N. A. Alekseeva, G. V. Lutcenko, D. M. Chudakov, E. I. Kovalenko
Publikováno v:
Медицинская иммунология, Vol 25, Iss 3, Pp 573-580 (2023)
Human cytomegalovirus (hCMV) is a prevalent virus that affects a large proportion of the population worldwide. Natural Killer (NK) cells are essential immune cells that play a crucial role in controlling hCMV infection. Despite the wide spread of hCM
Externí odkaz:
https://doaj.org/article/b6f9a7c9ff304bf196c6f810ca4cd5ce
Autor:
Oksana V. Stanevich, Evgeniia I. Alekseeva, Maria Sergeeva, Artem V. Fadeev, Kseniya S. Komissarova, Anna A. Ivanova, Tamara S. Simakova, Kirill A. Vasilyev, Anna-Polina Shurygina, Marina A. Stukova, Ksenia R. Safina, Elena R. Nabieva, Sofya K. Garushyants, Galya V. Klink, Evgeny A. Bakin, Jullia V. Zabutova, Anastasia N. Kholodnaia, Olga V. Lukina, Irina A. Skorokhod, Viktoria V. Ryabchikova, Nadezhda V. Medvedeva, Dmitry A. Lioznov, Daria M. Danilenko, Dmitriy M. Chudakov, Andrey B. Komissarov, Georgii A. Bazykin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Here, the authors report accelerated intrahost evolution of SARS-CoV-2 in an immunocompromised patient with non-Hodgkin’s lymphoma with 318 days long COVID-19, and show that changes in the viral genome resulted in escape from T cellular immune resp
Externí odkaz:
https://doaj.org/article/93775c7073a7473ba33c53b0af8cd634
Autor:
Anastasia O. Smirnova, Anna M. Miroshnichenkova, Laima D. Belyaeva, Ilya V. Kelmanson, Yuri B. Lebedev, Ilgar Z. Mamedov, Dmitriy M. Chudakov, Alexander Y. Komkov
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
T-cell receptor (TR) diversity of the variable domains is generated by recombination of both the alpha (TRA) and beta (TRB) chains. The textbook process of TRB chain production starts with TRBD and TRBJ gene rearrangement, followed by the rearrangeme
Externí odkaz:
https://doaj.org/article/7c744d23d4c24f8fa70e56c8a7bd5e3e
Autor:
Dmitrii S. Shcherbinin, Vadim K. Karnaukhov, Ivan V. Zvyagin, Dmitriy M. Chudakov, Mikhail Shugay
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionT-cell receptor (TCR) recognition of foreign peptides presented by the major histocompatibility complex (MHC) initiates the adaptive immune response against pathogens. While a large number of TCR sequences specific to different antigenic
Externí odkaz:
https://doaj.org/article/049b3dfacefa45d383e8fc31bcba2959
Autor:
Maria O. Ustiuzhanina, Maria A. Streltsova, Nikita D. Timofeev, Maxim A. Kryukov, Dmitriy M. Chudakov, Elena I. Kovalenko
Publikováno v:
Cells, Vol 13, Iss 6, p 530 (2024)
NK cells play a decisive role in controlling hCMV infection by combining innate and adaptive-like immune reactions. The hCMV-derived VMAPRTLFL (LFL) peptide is a potent activator of NKG2C+ NK cells. Proposed here is an autologous system of LFL stimul
Externí odkaz:
https://doaj.org/article/77ff7f1944194e9f9441f9447796d994
Autor:
Mathew Clement, Kristin Ladell, Kelly L Miners, Morgan Marsden, Lucy Chapman, Anna Cardus Figueras, Jake Scott, Robert Andrews, Simon Clare, Valeriia V Kriukova, Ksenia R Lupyr, Olga V Britanova, David R Withers, Simon A Jones, Dmitriy M Chudakov, David A Price, Ian R Humphreys
Publikováno v:
eLife, Vol 12 (2023)
Inhibitory CD4+ T cells have been linked with suboptimal immune responses against cancer and pathogen chronicity. However, the mechanisms that underpin the development of these regulatory cells, especially in the context of ongoing antigen exposure,
Externí odkaz:
https://doaj.org/article/2ebd05a7a8214cc583977dd47ed817fc