Zobrazeno 1 - 10
of 88
pro vyhledávání: '"M. Christina White"'
Publikováno v:
Nature chemistry
Despite significant progress in the development of site-selective aliphatic C–H oxidations over the past decade, the ability to oxidize strong methylene C–H bonds in the presence of more oxidatively labile aromatic functionalities remains a major
Autor:
Martins S. Oderinde, M. Christina White, Jeffrey T. Kohrt, Raundi E. Quevedo, Usa Reilly, Kaibo Feng
Publikováno v:
Nature
Frequently referred to as the 'magic methyl effect', the installation of methyl groups-especially adjacent (α) to heteroatoms-has been shown to dramatically increase the potency of biologically active molecules1-3. However, existing methylation meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0578f0b225ab399f972986c5e583b455
https://europepmc.org/articles/PMC8006464/
https://europepmc.org/articles/PMC8006464/
Publikováno v:
Advanced synthesiscatalysis. 362(2)
Aromatic and heterocyclic functionality are ubiquitous in pharmaceuticals. Herein, we disclose a new Mn(PDP)catalyst system using chloroacetic acid additive capable of chemoselectively oxidizing remote tertiary C(sp(3))—H bonds in the presence of a
Autor:
Jinpeng Zhao, M. Christina White
Publikováno v:
Journal of the American Chemical Society. 140:13988-14009
The atomistic change of C(sp(3))—H to C(sp(3))—O can have a profound impact on the physical and biological properties of small molecules. Traditionally, chemical synthesis has relied on pre-existing functionality to install new functionality, and
Publikováno v:
Nature Chemistry. 10:583-591
Reactions that directly install nitrogen into C-H bonds of complex molecules are significant because of their potential to change the chemical and biological properties of a given compound. Although selective intramolecular C-H amination reactions ar
Autor:
Rulin Ma, M. Christina White
Publikováno v:
Journal of the American Chemical Society. 140:3202-3205
Cross-coupling of nitrogen with hydrocarbons under fragment coupling conditions stands to significantly impact chemical synthesis. Herein, we disclose a C(sp3)–N fragment coupling reaction between terminal olefins and N-triflyl protected aliphatic
Publikováno v:
Journal of the American Chemical Society. 139:13624-13627
The catalytic transformation of a C(sp3)–H bond to a C(sp3)–C bond via an iron carbene intermediate represents a long-standing challenge. Despite the success of enzymatic and small molecule iron catalysts mediating challenging C(sp3)–H oxidatio
Autor:
Rulin Ma, Christopher C. Pattillo, Rossella Promontorio, Jonathon Young, Friederike M. Dannheim, M. Christina White
We report the development of a Pd(II)/(±)-MeO-SOX/2,5-dimethylbenzoquinone system that enables unprecedented access to anti-1,3 amino alcohol motifs in good yields (33 substrates, avg. 66% isolated yield, >20:1 dr) and high selectivities (avg. 10:1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb4c327115e6d804f6034713b39421d
https://europepmc.org/articles/PMC7043790/
https://europepmc.org/articles/PMC7043790/
Akademický článek
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Autor:
Thomas J. Osberger, Donald C. Rogness, Antonia F. Stepan, M. Christina White, Jeffrey T. Kohrt
Publikováno v:
Nature
Secondary metabolites synthesized by nonribosomal peptide synthetases (NRPSs) display diverse and complex topologies and possess an impressive range of biological activities1,2 Much of this diversity derives from a synthetic strategy that entails the