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Yttrium-90 – Current Status, Expected Availability and Applications of a High Beta Energy Emitter

Autor: R. Leyva Montaña, A. Alberti Ramirez, I. Hernandez Gonzalez, M. Chinol, L. Garaboldi

Publikováno v: Current Radiopharmaceuticals. 5:253-263

Yttrium-90 ((90)Y, T(1/2) 64.14 h) is a key example of a high beta energy-emitting radionuclide which is available from the strontium-90 ((90)Sr)/(90)Y radionuclide generator system. Clinical uses of (90)Y-labeled radiopharmaceutical agents have been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25105ba92d5a222af0227bf497c605b4
https://doi.org/10.2174/1874471011205030253

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Evaluation of fresh and old eluate of 99Mo/99mTc generators used for labeling of different pharmaceutical kits

Autor: M. Guerra, Nicoletta Urbano, S. Modoni, M. Chinol

Publikováno v: Journal of Radioanalytical and Nuclear Chemistry. 265:7-10

Sixty 99Mo/99mTc wet column generators, loaded with two different 99Mo activities, were analyzed in order to assess the quality of their eluates. Each elution was used for labeling of different radiopharmaceuticals, in order to evaluate whether “ri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::269d5d644c89b2b0cafe5d7e8427eba2
https://doi.org/10.1007/s10967-005-0782-x

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Testing of microbial contamination during the preparation of the radiocompound [⁹⁰Y]DOTATOC for clinical trials: a process validation study by Media Fill approach

Autor: V, Sirna, L, Garaboldi, S, Papi, L, Martano, E, Omodeo Salè, G, Paganelli, M, Chinol

Publikováno v: The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of.... 54(5)

Radioisotopes used in nuclear radiopharmacy possess short half-lives, not allowing enough time to wait for completion of sterility tests. Moreover, carrying out sterility tests on highly radioactive solutions inside the hospital microbiology laborato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8af41f25885c5d0dadd723b2076f4eb3
https://pubmed.ncbi.nlm.nih.gov/20927022

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The humoral immune response to macrocyclic chelating agent DOTA depends on the carrier molecule

Autor: M E, Perico, M, Chinol, A, Nacca, E, Luison, G, Paganelli, S, Canevari

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 42(11)

The chelating agent 1,4,7,10-tetraazacyclododecane-N,N', N",N"'-tetraacetic acid (DOTA) is used to label monoclonal antibodies (mAbs) and peptides with (90)Y. DOTA allows the generation of clinically useful stable metallic radioconjugates for the tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c7f7b00cb0e6e3bfb5dfd34cabdbe663
https://pubmed.ncbi.nlm.nih.gov/11696642

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111In-labeled 1,4,7,10-tetraazacyclododecane-N,N',N',N''-tetraacetic acid-lys(8)-vasotocin: a new powerful radioligand for oxytocin receptor-expressing tumors

Autor: G, Bussolati, M, Chinol, B, Chini, A, Nacca, P, Cassoni, G, Paganelli

Publikováno v: Cancer research. 61(11)

We developed a radioactive ligand for tumors expressing oxytocin receptors (OTRs) by linking the chelating agent 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid (DOTA) to Lys(8)-vasotocin (LVT), an analogue of oxytocin with high affinity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a1cb80fac48c2e4e599e64929fbc3864
https://pubmed.ncbi.nlm.nih.gov/11389066

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Dosimetry in radionuclide therapies with 90Y-conjugates: the IEO experience

Autor: M, Cremonesi, M, Ferrari, M, Chinol, M, Bartolomei, M G, Stabin, E, Sacco, M, Fiorenza, G, Tosi, G, Paganelli

Publikováno v: The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR). 44(4)

The basis for a successful radionuclide therapy is a high and stable uptake of the radiopharmaceutical in the target tissue along with low activity concentration in other normal organs. The contribution of dosimetry in radionuclide therapy is to pred

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::feb481eec24ce22bf2b53fd59bfa6237
https://pubmed.ncbi.nlm.nih.gov/11302260

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Radiation protection in radioguided surgery of breast cancer

Autor: Viviana Galimberti, Giampiero Tosi, E. Sacco, Mahila Ferrari, Annalisa Rossi, Alberto Luini, C. De Cicco, Marta Cremonesi, Umberto Veronesi, Giovanni Paganelli, M. Chinol, L. Leonardi

Publikováno v: Nuclear medicine communications. 20(10)

The protocols for sentinel lymph node biopsy and radioguided occult lesion localization could potentially be of great value in the management of breast cancer patients. Both involve the injection of a 99 Tc m -labelled radiopharmaceutical close to or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5cf7d34ed3f9e65f547dacd2cc0a50b
https://pubmed.ncbi.nlm.nih.gov/10528297

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