Azithromycin analogue CSY0073 attenuates lung inflammation induced by LPS challenge

Autor: V, Balloy, A, Deveaux, D, Lebeaux, O, Tabary, P, le Rouzic, J M, Ghigo, P F, Busson, P Y, Boëlle, J Guez, Guez, U, Hahn, A, Clement, M, Chignard, H, Corvol, M, Burnet, L, Guillot

Publikováno v: British Journal of Pharmacology
British Journal of Pharmacology, Wiley, 2014, 171 (7), pp.1783-1794. ⟨10.1111/bph.12574⟩
British Journal of Pharmacology, 2014, 171 (7), pp.1783-1794. ⟨10.1111/bph.12574⟩

International audience; BACKGROUND AND PURPOSE:Azithromycin is a macrolide antibiotic with anti-inflammatory and immunomodulating effects. Long-term azithromycin therapy in patients with chronic lung diseases such as cystic fibrosis has been associat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2c4923794f6911e0ac7146dc9951da28
https://hal-pasteur.archives-ouvertes.fr/pasteur-02017403

Leucocyte elastase-mediated release of von Willebrand factor from cultured endothelial cells

Autor: M Chignard, V Balloy, P Renesto

Publikováno v: European Respiratory Journal. 6:791-796

The aim of this study was to investigate a possible activation of human endothelial cells in monolayer culture by a purified neutrophil-derived proteinase, i.e. elastase. Cells were isolated from human umbilical cord veins, and incubated either in pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46c6b9ea32ce29c0e26f965259973356
https://doi.org/10.1183/09031936.93.06060791

Systemic administration of endotoxin induces bronchopulmonary hyperreactivity dissociated from TNF-alpha formation and neutrophil sequestration into the murine lungs

Autor: J, Lefort, M, Singer, D, Leduc, P, Renesto, M A, Nahori, M, Huerre, C, Créminon, M, Chignard, B B, Vargaftig

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 161(1)

Bronchopulmonary hyperreactivity (BHR), an increased responsiveness to nonspecific bronchoconstrictor agents, is a well-known characteristic of bronchial asthma. It has been recently suggested that the severity of this disease is related to the endot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9ff501b9899a5b4726e7565e9e841298
https://pubmed.ncbi.nlm.nih.gov/9647258

Synergism between interleukin-8 and tumor necrosis factor-alpha for neutrophil-mediated platelet activation

Autor: M, Si Tahar, P, Renesto, V, Balloy, M, Chignard

Publikováno v: European cytokine network. 5(5)

We previously showed that two polymorphonuclear neutrophil (PMN)-derived proteinases, namely cathepsin G (Cat. G) and elastase (HLE), acting in synergy activated nearby platelets in vitro. This cellular interaction could result in a pathology such as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f973475c59a2e4533d56eac0dbb426da
https://pubmed.ncbi.nlm.nih.gov/7880976

Heparin inhibits neutrophil-induced platelet activation via cathepsin G

Autor: P, Ferrer-Lopez, P, Renesto, M C, Prevost, P, Gounon, M, Chignard

Publikováno v: The Journal of laboratory and clinical medicine. 119(3)

Activated human polymorphonuclear neutrophils (PMNs) induce platelet stimulation via cathepsin G (cat G), a platelet-activating cationic serine proteinase released from the azurophilic granules. Heparin inhibited up to 100% of aggregation and seroton

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e501a56f90bdb936d6b399e99855b263
https://pubmed.ncbi.nlm.nih.gov/1541873