Zobrazeno 1 - 10 of 190 pro vyhledávání: '"M. Chamuleau"'
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Akademický článek
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Akademický článek
A practice-changing culture method relying on shaking substantially increases mitochondrial energy metabolism and functionality of human liver cell lines.
Autor: Aziza A A Adam, Vincent A van der Mark, Joanne M Donkers, Manon E Wildenberg, Ronald P J Oude Elferink, Robert A F M Chamuleau, Ruurdtje Hoekstra
Publikováno v: PLoS ONE, Vol 13, Iss 4, p e0193664 (2018)
Practice-changing culturing techniques of hepatocytes are highly required to increase their differentiation. Previously, we found that human liver cell lines HepaRG and C3A acquire higher functionality and increased mitochondrial biogenesis when cult
Externí odkaz: https://doaj.org/article/dda135b9f4ac477fa76ca8c842d09a26
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5
End-stage liver failure: filling the treatment gap at the intensive care unit
Autor: Ruurdtje Hoekstra, Robert A. F. M. Chamuleau
Publikováno v: Journal of Artificial Organs
End-stage liver failure is a condition of collapsing liver function with mortality rates up to 80. Liver transplantation is the only lifesaving therapy. There is an unmet need for therapy to extend the waiting time for liver transplantation or regene
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef6462e165af3389f00b2ce46b2567c5
http://europepmc.org/articles/PMC7228976
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Overexpression of the constitutive androstane receptor and shaken 3D-culturing increase biotransformation and oxidative phosphorylation and sensitivity to mitochondrial amiodarone toxicity of HepaRG cells
Autor: Vincent A. van der Mark, Aziza A. A. Adam, Ronald P.J. Oude Elferink, Ruurdtje Hoekstra, Jung-Chin Chang, Robert A. F. M. Chamuleau
Publikováno v: Toxicology and applied pharmacology, 399:115055. Academic Press Inc.
The liver cell line HepaRG is one of the preferred sources of human hepatocytes for in vitro applications. However, mitochondrial energy metabolism is relatively low, which affects hepatic functionality and sensitivity to hepatotoxins. Culturing in a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf35c552b5d892608f89306eed2c438
https://pubmed.ncbi.nlm.nih.gov/32428594
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7
Akademický článek
Prediction of poor outcome in patients with acute liver failure-systematic review of prediction models.
Autor: Kama A Wlodzimirow, Saeid Eslami, Robert A F M Chamuleau, Martin Nieuwoudt, Ameen Abu-Hanna
Publikováno v: PLoS ONE, Vol 7, Iss 12, p e50952 (2012)
IntroductionAcute liver failure is a rare disease with high mortality and liver transplantation is the only life saving therapy. Accurate prognosis of ALF is crucial for proper intervention.AimTo identify and characterize newly developed prognostic m
Externí odkaz: https://doaj.org/article/663ebd827bfa42dbb28d8d0b8f6af24f
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8
Akademický článek
Liver progenitor cell line HepaRG differentiated in a bioartificial liver effectively supplies liver support to rats with acute liver failure.
Autor: Geert A A Nibourg, Robert A F M Chamuleau, Tessa V van der Hoeven, Martinus A W Maas, An F C Ruiter, Wouter H Lamers, Ronald P J Oude Elferink, Thomas M van Gulik, Ruurdtje Hoekstra
Publikováno v: PLoS ONE, Vol 7, Iss 6, p e38778 (2012)
A major roadblock to the application of bioartificial livers is the need for a human liver cell line that displays a high and broad level of hepatic functionality. The human bipotent liver progenitor cell line HepaRG is a promising candidate in this
Externí odkaz: https://doaj.org/article/6c1861603e0d4671ab5f49e67411a5eb
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9
HepaRG-Progenitor Cell Derived Hepatocytes Cultured in Bioartificial Livers Are Protected from Healthy- and Acute Liver Failure-Plasma Induced Toxicity
Autor: Ronald P.J. Oude Elferink, Thomas M. van Gulik, Vincent A. van der Mark, Philipp Treskes, Robert A. F. M. Chamuleau, Martien van Wenum, Aziza A. A. Adam, Aldo Jongejan, Ruurdtje Hoekstra, Perry D. Moerland
Publikováno v: Cellular Physiology and Biochemistry, Vol 48, Iss 5, Pp 2189-2204 (2018)
Cellular physiology and biochemistry, 48(5), 2189-2204. S. Karger AG
Background/Aims: For applicability of cell-based therapies aimed at the treatment of liver failure, such as bioartificial livers (BALs) and hepatocyte transplantation, it is essential that the applied hepatocytes tolerate exposure to the patient plas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d74ae72275fa9dbad0975e70e79bf0f9
https://doi.org/10.1159/000492560
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10
Akademický článek
In Vitro Functionality of Human Fetal Liver Cells and Clonal Derivatives under Proliferative Conditions
Autor: Tanja Deurholt, Lysbeth Ten Bloemendaal, Aniska A. Chhatta, Albert C. W. A. Van Wijk, Kees Weijer, Jurgen Seppen, Ronald P. J. Oude Elferink, Robert A. F. M. Chamuleau, Ruurdtje Hoekstra
Publikováno v: Cell Transplantation, Vol 15 (2006)
Mature human hepatocytes are not suitable for large-scale in vitro applications that rely on hepatocyte function, due to their limited availability and insufficient proliferation capacity in vitro. In contrast, human fetal liver cells (HFLC) can be e
Externí odkaz: https://doaj.org/article/cb20d7667db94b94bda82a82a84d99e2
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