Cannabinoid tolerance and dependence: A review of studies in laboratory animals

Autor: Sara González, M. Cebeira, Javier Fernández-Ruiz

Publikováno v: Pharmacology Biochemistry and Behavior. 81:300-318

Two are the issues on cannabis addiction that provoke more controversy from a research perspective. The first one is related to the development of tolerance phenomena and, in particular, of a dependence state after chronic cannabinoid consumption, wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade108ef31a7d298dbbffdfc931cbbc4
https://doi.org/10.1016/j.pbb.2005.01.028

Changes in endocannabinoid transmission in the basal ganglia in a rat model of Huntington's disease

Autor: M. Cebeira, Javier Fernández-Ruiz, José A. Ramos, Filomena Fezza, Tiziana Bisogno, Isabel Lastres-Becker, Vincenzo Di Marzo, A. Milone

Publikováno v: NeuroReport (Oxf.) 12 (2001): 2125–2129.
info:cnr-pdr/source/autori:Lastres-Becker I., Fezza F., Cebeira M., Bisogno T., Ramos J.A., Milone A., Fernandez-Ruiz J. and Di Marzo V./titolo:Changes in endocannabinoid transmission in the basal ganglia in a rat model of Huntington?s disease/doi:/rivista:NeuroReport (Oxf.)/anno:2001/pagina_da:2125/pagina_a:2129/intervallo_pagine:2125–2129/volume:12
Scopus-Elsevier

Recent studies have demonstrated a loss of cannabinoid CB1 receptors in the basal ganglia in Huntington's disease (HD), but there are no data on endocannabinoid levels in this disease. In the present study, we have addressed this question by using ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a111d20f174d217a2da070b0d6165615
https://doi.org/10.1097/00001756-200107200-00017

Brain Regional Distribution of Endocannabinoids: Implications for Their Biosynthesis and Biological Function

Autor: Fernando Berrendero, M. Cebeira, J.J. Fernández-Ruiz, Gerolmina Ambrosino, V. Di Marzo, Tiziana Bisogno, J.A. Ramos

Publikováno v: Biochemical and Biophysical Research Communications. 256:377-380

The amounts, in nine different rat brain regions, of the two endocannabinoids, anandamide (arachidonoylethanolamide, AEA) and 2-arachidonoylglycerol (2-AG), and of the putative AEA precursor N-arachidonoyl-phosphatidylethanolamine (NArPE), were deter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::475465e78f9946a0a1e5047986dd2c50
https://doi.org/10.1006/bbrc.1999.0254

Changes in rat brain cannabinoid binding sites after acute or chronic exposure to their endogenous agonist, anandamide, or to δ9-tetrahydrocannabinol

Autor: J.A. Ramos, Lilia M. Urdaneta García, J.J. Fernández-Ruiz, M. Cebeira, Julián Romero

Publikováno v: Pharmacology Biochemistry and Behavior. 51:731-737

A brain constituent, the N-amide derivative of arachidonic acid, termed anandamide, has been recently proposed as a possible endogenous ligand for the cannabinoid receptor. The present study has been designed to examine whether the acute or chronic e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb87d045501e7ef6745882c587332e9
https://doi.org/10.1016/0091-3057(95)00023-p

Modifications of mesolimbic and nigrostriatal dopaminergic activities after intracerebroventricular administration of prolactin

Autor: M. Cebeira, J.J. Fernández-Ruiz, Medardo Hernández, R. de Miguel, J.A. Ramos, L. Vaticón, Miguel Navarro

Publikováno v: Journal of Neural Transmission. 96:63-79

In the present study we examined the effects of intracerebroventricular (i.c.v.) injections of prolactin (PRL) on the presynaptic activity and post-synaptic sensitivity of mesolimbic and nigrostriatal dopaminergic neurons. In addition, the effects of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a427d607a70ac5bb38eba8d207d3fe9f
https://doi.org/10.1007/bf01277929