Zobrazeno 1 - 6
of 6
pro vyhledávání: '"M. Carolyn Fisher"'
Autor:
Pamela J. Hornby, Bruce P. Damiano, Alexey B. Dyatkin, N. H. Wallace, M. Carolyn Fisher, Stephen M. Prouty, Bruce E. Maryanoff, Edward S. Kimball, Wei He, Rosemary J. Santulli, Craig R. Schneider, Yong Gong, William A. Kinney, Craig J. Diamond, Tamara A. Miskowski
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:6693-6702
A series of N-carboxy, N-alkyl, and N-carboxamido azabicyclo[2.2.2]octane carboxamides were prepared and assayed for inhibition of α4β1-VCAM-1 and α4β7-MAdCAM-1 interactions. Potency and α4β1/α4β7 selectivity were sensitive to the substituent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04fac0ca403e4acd6788a9ee123e776a
https://doi.org/10.1016/j.bmc.2005.07.022
https://doi.org/10.1016/j.bmc.2005.07.022
Autor:
Dennis J. Hlasta, Stephen M. Prouty, Wei He, Bruce P. Damiano, William J. Hoekstra, Pamela J. Hornby, M. Carolyn Fisher, William A. Kinney, Patricia Andrade-Gordon, Alexey B. Dyatkin, William M. Abraham, Edward S. Kimball, Maria Kontoyianni, Bruce E. Maryanoff, Rosemary J. Santulli
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:591-596
The design, synthesis, and biological activity of novel α 4 β 1 and α 4 β 7 integrin antagonists, containing a bridged azabicyclic nucleus, are reported. Conformational analysis of targets containing an azabicyclo[2.2.2]octane carboxylic acid and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::479b6bb212e629c9276b9ca2655baca7
https://doi.org/10.1016/j.bmcl.2003.11.063
https://doi.org/10.1016/j.bmcl.2003.11.063
Autor:
Alexey B, Dyatkin, William J, Hoekstra, William A, Kinney, Maria, Kontoyianni, Rosemary J, Santulli, Edward S, Kimball, M Carolyn, Fisher, M, Carolyn Fisher, Stephen M, Prouty, William M, Abraham, Lawrence, de Garavilla, Patricia, Andrade-Gordon, Dennis J, Hlasta, Wei, He, Pamela J, Hornby, Bruce P, Damiano, Bruce E, Maryanoff
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(3)
The design, synthesis, and biological activity of novel alpha(4)beta(1) and alpha(4)beta(7) integrin antagonists, containing a bridged azabicyclic nucleus, are reported. Conformational analysis of targets containing an azabicyclo[2.2.2]octane carboxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::021ce3a645f4ef4747e09fdc601f6603
https://pubmed.ncbi.nlm.nih.gov/14741249
https://pubmed.ncbi.nlm.nih.gov/14741249
Publikováno v:
Cellular immunology. 113(2)
Balb/3T3 fibroblasts respond to interleukin-1 (IL-1) by proliferating in a dose-dependent fashion. Increasing proliferative responses were observed with increasing IL-1 concentration in serum-free medium when the medium was supplemented with insulin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e28c821f43707a9bbfdd09008babf5b
https://pubmed.ncbi.nlm.nih.gov/3282679
https://pubmed.ncbi.nlm.nih.gov/3282679
Akademický článek
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Autor:
Dyatkin AB; Drug Discovery, Johnson & Johnson Pharmaceutical Research & Development, LLC, Spring House, PA 19477-0776, USA. adyatkin@prdus.jnj.com, Hoekstra WJ, Kinney WA, Kontoyianni M, Santulli RJ, Kimball ES, Fisher MC, Prouty SM, Abraham WM, de Garavilla L, Andrade-Gordon P, Hlasta DJ, He W, Hornby PJ, Damiano BP, Maryanoff BE
Publikováno v:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2004 Feb 09; Vol. 14 (3), pp. 591-6.