Výsledky vyhledávání - "M. Carolina Gallego Iradi"

Akademický článek

Subcellular Localization of Matrin 3 Containing Mutations Associated with ALS and Distal Myopathy.

Autor: M Carolina Gallego-Iradi, Alexis M Clare, Hilda H Brown, Christopher Janus, Jada Lewis, David R Borchelt

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0142144 (2015)

Mutations in Matrin 3 [MATR3], an RNA- and DNA-binding protein normally localized to the nucleus, have been linked to amyotrophic lateral sclerosis (ALS) and distal myopathies. In the present study, we have used transient transfection of cultured cel

Externí odkaz: https://doaj.org/article/ee9ff757edba4919afbe11983b73032d

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N-terminal sequences in Matrin 3 mediate phase separation into droplet-like structures that recruit TDP43 variants lacking RNA binding elements

Autor: M. Carolina Gallego-Iradi, Edgardo Rodriguez-Lebron, Haley Strunk, Anthony M. Crown, Rachel Davila, David R. Borchelt, Hilda Brown

Publikováno v: Laboratory investigation; a journal of technical methods and pathology

RNA binding proteins associated with amyotrophic lateral sclerosis (ALS) and muscle myopathy possess sequence elements that are low in complexity, or bear resemblance to yeast prion domains. These sequence elements appear to mediate phase separation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fbc6bc96c67e5a52cfaac015f312e1f
http://europepmc.org/articles/PMC6857798

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Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy

Autor: Maurice S. Swanson, Edgardo Rodriguez-Lebron, Rachel Davila, Hilda Brown, Jada Lewis, Judy C. Triplett, James D. Thomas, David R. Borchelt, M. Carolina Gallego Iradi, Anthony M. Crown, Guilian Xu

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)

To understand how mutations in Matrin 3 (MATR3) cause amyotrophic lateral sclerosis (ALS) and distal myopathy, we used transcriptome and interactome analysis, coupled with microscopy. Over-expression of wild-type (WT) or F115C mutant MATR3 had little

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fac6ff3e3fd9b621ae742bda60fe282
https://pubmed.ncbi.nlm.nih.gov/29511296

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Subcellular Localization of Matrin 3 Containing Mutations Associated with ALS and Distal Myopathy

Autor: Christopher Janus, Hilda Brown, David R. Borchelt, Jada Lewis, M. Carolina Gallego-Iradi, Alexis M. Clare

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0142144 (2015)
PLoS ONE

Background Mutations in Matrin 3 [MATR3], an RNA- and DNA-binding protein normally localized to the nucleus, have been linked to amyotrophic lateral sclerosis (ALS) and distal myopathies. In the present study, we have used transient transfection of c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816a17c4eae7e2332bd838add424de2e
http://europepmc.org/articles/PMC4631352?pdf=render

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