Zobrazeno 1 - 10
of 1 257
pro vyhledávání: '"M. Carola"'
Autor:
Tianqi Lu, Lies Lahousse, Sara Wijnant, Jinluan Chen, Guy G. Brusselle, Mandy van Hoek, M. Carola Zillikens
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-10 (2024)
Background Chronic obstructive pulmonary disease (COPD) and asthma associate with high morbidity and mortality. High levels of advanced glycation end products (AGEs) were found in tissue and plasma of COPD patients but their role in COPD and asthma i
Externí odkaz:
https://doaj.org/article/9d264901351b4d9abb2ce8b66a47e855
Autor:
Sanne S. Mooldijk, Tianqi Lu, Komal Waqas, Jinluan Chen, Meike W. Vernooij, M. Kamran Ikram, M. Carola Zillikens, M. Arfan Ikram
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Conditions such as hyperglycemia and oxidative stress lead to the formation of advanced glycation end products (AGEs), which are harmful compounds that have been implicated in dementia. Within the Rotterdam Study, we measured skin AGEs as sk
Externí odkaz:
https://doaj.org/article/e291768675e64f4394b8aba82d2dca33
Autor:
Danielle M.A. Ratsma, Max Muller, Marijke Koedam, Johannes P.T.M. van Leeuwen, M. Carola Zillikens, Bram C.J. van der Eerden
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109625- (2024)
Summary: One of the main regulators of phosphate homeostasis is fibroblast growth factor 23 (FGF23), secreted by osteocytes. The effects of organic versus inorganic dietary phosphate on this homeostasis are unclear. This study used MC3T3-E1 FGF23-pro
Externí odkaz:
https://doaj.org/article/d3d1adb206564da08036f8f46f3551e1
Autor:
Annemieke M. Boot, Gema Ariceta, Signe Sparre Beck-Nielsen, Maria Luisa Brandi, Karine Briot, Carmen de Lucas Collantes, Sandro Giannini, Dieter Haffner, Richard Keen, Elena Levtchenko, M. Zulf Mughal, Outi Mӓkitie, Ola Nilsson, Dirk Schnabel, Liana Tripto-Shkolnik, M. Carola Zillikens, Jonathan Liu, Alina Tudor, Francesco Emma
Publikováno v:
Therapeutic Advances in Chronic Disease, Vol 15 (2024)
Background: X-linked hypophosphatemia (XLH) is a rare, progressive disorder characterized by excess fibroblast growth factor 23 (FGF23), causing renal phosphate-wasting and impaired active vitamin D synthesis. Burosumab is a recombinant human monoclo
Externí odkaz:
https://doaj.org/article/ad24bc6611d64fadbf932d2c17d3938c
Autor:
Jinluan Chen, Banafsheh Arshi, Komal Waqas, Tianqi Lu, Daniel Bos, M. Arfan Ikram, André G. Uitterlinden, Maryam Kavousi, M. Carola Zillikens
Publikováno v:
Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-13 (2023)
Abstract Background Advanced glycation end products (AGEs) have been linked to cardiovascular disease (CVD), especially coronary heart disease (CHD), but their role in CVD pathogenesis remains unclear. Therefore, we investigated cross-sectional assoc
Externí odkaz:
https://doaj.org/article/991addbd556249ada1e797b114430ae8
Autor:
Wenchao Zhong, Janine Neugebauer, Janak L. Pathak, Xingyang Li, Gerard Pals, M. Carola Zillikens, Elisabeth M. W. Eekhoff, Nathalie Bravenboer, Qingbin Zhang, Matthias Hammerschmidt, Brunhilde Wirth, Dimitra Micha
Publikováno v:
Cells, Vol 13, Iss 17, p 1507 (2024)
Plastin-3 (PLS3) encodes T-plastin, an actin-bundling protein mediating the formation of actin filaments by which numerous cellular processes are regulated. Loss-of-function genetic defects in PLS3 are reported to cause X-linked osteoporosis and chil
Externí odkaz:
https://doaj.org/article/4e95f3942500479782e68733c11087da
Autor:
Gema Ariceta, Signe Sparre Beck-Nielsen, Annemieke M. Boot, Maria Luisa Brandi, Karine Briot, Carmen de Lucas Collantes, Francesco Emma, Sandro Giannini, Dieter Haffner, Richard Keen, Elena Levtchenko, Outi Mӓkitie, M. Zulf Mughal, Ola Nilsson, Dirk Schnabel, Liana Tripto-Shkolnik, Jonathan Liu, Angela Williams, Sue Wood, M. Carola Zillikens
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 18, Iss 1, Pp 1-17 (2023)
Abstract Background X-linked hypophosphatemia (XLH) is a rare, hereditary, progressive, renal phosphate-wasting disorder characterized by a pathological increase in FGF23 concentration and activity. Due to its rarity, diagnosis may be delayed, which
Externí odkaz:
https://doaj.org/article/388123ab12ae45a9a9fad4c55b77739a
Autor:
Carolina Medina-Gomez, Benjamin H. Mullin, Alessandra Chesi, Vid Prijatelj, John P. Kemp, Chen Shochat-Carvalho, Katerina Trajanoska, Carol Wang, Raimo Joro, Tavia E. Evans, Katharina E. Schraut, Ruifang Li-Gao, Tarunveer S. Ahluwalia, M. Carola Zillikens, Kun Zhu, Dennis O. Mook-Kanamori, Daniel S. Evans, Maria Nethander, Maria J. Knol, Gudmar Thorleifsson, Ivana Prokic, Babette Zemel, Linda Broer, Fiona E. McGuigan, Natasja M. van Schoor, Sjur Reppe, Mikolaj A. Pawlak, Stuart H. Ralston, Nathalie van der Velde, Mattias Lorentzon, Kari Stefansson, Hieab H. H. Adams, Scott G. Wilson, M. Arfan Ikram, John P. Walsh, Timo A. Lakka, Kaare M. Gautvik, James F. Wilson, Eric S. Orwoll, Cornelia M. van Duijn, Klaus Bønnelykke, Andre G. Uitterlinden, Unnur Styrkársdóttir, Kristina E. Akesson, Timothy D. Spector, Jonathan H. Tobias, Claes Ohlsson, Janine F. Felix, Hans Bisgaard, Struan F. A. Grant, J. Brent Richards, David M. Evans, Bram van der Eerden, Jeroen van de Peppel, Cheryl Ackert-Bicknell, David Karasik, Erika Kague, Fernando Rivadeneira
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Skull bone mineral density (SK-BMD) provides a suitable trait for the discovery of key genes in bone biology, particularly to intramembranous ossification, not captured at other skeletal sites. We perform a genome-wide association meta-analy
Externí odkaz:
https://doaj.org/article/48a29b7a20594248bc9b5e7eb32dd872
Autor:
Anna G. W. Rosenberg, Ké Mochèl, Lorena M. Hähner, Lara Ruules, Kirsten Davidse, Anja G. Bos-Roubos, Sarah A. van Dijk, M. Carola Zillikens, Walter Taal, Aart J. van der Lely, Laura C. G. de Graaff
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2024)
ContextNeurofibromatosis type 1 (NF1) is a complex system disorder, caused by alterations in RAS pathways. NF1 adults often suffer from chronic and severe fatigue, for which they are frequently referred to Internal Medicine/Endocrinology. Seeking med
Externí odkaz:
https://doaj.org/article/c905e2f7b0944724b698c3897f073159
Publikováno v:
JBMR Plus, Vol 7, Iss 8, Pp n/a-n/a (2023)
ABSTRACT Osteosclerotic metaphyseal dysplasia (OSMD) is a very rare autosomal‐recessive disease caused by mutations in the leucine‐rich repeat kinase 1 (LRRK1) gene. It is a sclerosing skeletal dysplasia characterized by osteosclerosis of the lon
Externí odkaz:
https://doaj.org/article/d22b16d797ba45c290fc2a2b9572e2d3