Modulation by Sigma-1 Receptor of Morphine Analgesia and Tolerance: Nociceptive Pain, Tactile Allodynia and Grip Strength Deficits During Joint Inflammation

Autor: Ángeles Montilla-García, Miguel Á. Tejada, M. Carmen Ruiz-Cantero, Inmaculada Bravo-Caparrós, Sandra Yeste, Daniel Zamanillo, Enrique J. Cobos

Publikováno v: Frontiers in Pharmacology, Vol 10 (2019)

Sigma-1 receptor antagonism increases the effects of morphine on nociceptive pain, even in morphine-tolerant animals. However, it is unknown whether these receptors are able to modulate morphine antinociception and tolerance during inflammatory pain.

Externí odkaz: https://doaj.org/article/d96a8416ffc544b58e07f5614ea65072

Tetrodotoxin, a Potential Drug for Neuropathic and Cancer Pain Relief?

Autor: M. Carmen Ruiz-Cantero, Carlos Gómez-Navas, Rafael González-Cano, Miguel Á. Tejada, Francisco R. Nieto, Miriam Santos-Caballero

Publikováno v: Digibug. Repositorio Institucional de la Universidad de Granada
instname
Toxins
Toxins, Vol 13, Iss 483, p 483 (2021)

This publication was partially supported by grant CTS 109 from the Junta de Andalucia, grant INTRAIBS-2020-09 from Biosanitary Research Institute ibs.GRANADA, and grant PPJIA2020-06 from the University of Granada.
Tetrodotoxin (TTX) is a potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450febaf6ef3bd4425cc645c5b6f7964
https://www.mdpi.com/2072-6651/13/7/483/pdf?version=1626583474

Sigma-1 receptor: A drug target for the modulation of neuroimmune and neuroglial interactions during chronic pain

Autor: Rafael González-Cano, Miriam Santos-Caballero, Enrique J. Cobos, M. Carmen Ruiz-Cantero, Francisco R. Nieto, Gloria Perazzoli, Miguel Á. Tejada

Publikováno v: Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Digibug. Repositorio Institucional de la Universidad de Granada
instname

Immune and glial cells play a pivotal role in chronic pain. Therefore, it is possible that the pharmacological modulation of neurotransmission from an exclusively neuronal perspective may not be enough for adequate pain management, and the modulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc93204b9d9318392f04c6afb7cf8bc4

The search for translational pain outcomes to refine analgesic development: Where did we come from and where are we going?

Autor: Miguel Á. Tejada, Inmaculada Bravo-Caparrós, Ángeles Montilla-García, Rafael González-Cano, Enrique J. Cobos, M. Carmen Ruiz-Cantero, Francisco R. Nieto

Publikováno v: Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Digibug. Repositorio Institucional de la Universidad de Granada
Consejo Superior de Investigaciones Científicas (CSIC)

Pain measures traditionally used in rodents record mere reflexes evoked by sensory stimuli; the results thus may not fully reflect the human pain phenotype. Alterations in physical and emotional functioning, pain-depressed behaviors and facial pain e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7387286c253198460636f08772c5bea
https://pubmed.ncbi.nlm.nih.gov/32147529

Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice

Autor: José M. Baeyens, Shane J. F. Cronin, M. Carmen Ruiz-Cantero, Miguel Á. Tejada, Rafael González-Cano, Domagoj Cikes, Cristina Sánchez-Fernández, Josef M. Penninger, Enrique J. Cobos, José Miguel Vela, Ángeles Montilla-García

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 114(31)

Sigma-1 antagonism potentiates the antinociceptive effects of opioid drugs, so sigma-1 receptors constitute a biological brake to opioid drug-induced analgesia. The pathophysiological role of this process is unknown. We aimed to investigate whether s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa73bcc2b3a0b15c6137d914a716ecc5
https://pubmed.ncbi.nlm.nih.gov/28716934