Chimeric Drug Design with a Noncharged Carrier for Mitochondrial Delivery

Autor: Consuelo Ripoll, Pilar Herrero-Foncubierta, Virginia Puente-Muñoz, M. Carmen Gonzalez-Garcia, Delia Miguel, Sandra Resa, Jose M. Paredes, Maria J. Ruedas-Rama, Emilio Garcia-Fernandez, Mar Roldan, Susana Rocha, Herlinde De Keersmaecker, Johan Hofkens, Miguel Martin, Juan M. Cuerva, Angel Orte

Publikováno v: Pharmaceutics, Vol 13, Iss 2, p 254 (2021)

Recently, it was proposed that the thiophene ring is capable of promoting mitochondrial accumulation when linked to fluorescent markers. As a noncharged group, thiophene presents several advantages from a synthetic point of view, making it easier to

Externí odkaz: https://doaj.org/article/59260eca63a24991bbeef9d9556d8699

Optical Binding‐Driven Micropatterning and Photosculpting with Silver Nanorods

Autor: M. Carmen Gonzalez‐Garcia, Emilio Garcia‐Fernandez, Jose L. Hueso, Pedro M. R. Paulo, Angel Orte

Publikováno v: Small Methods.

Controlling the nano- and micropatterning of metal structures is an important requirement for various technological applications in photonics and biosensing. This work presents a method for controllably creating silver micropatterns by laser-induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5562bc9153ba471f407e935764e604a2
https://doi.org/10.1002/smtd.202300076

Building Accurate Intracellular Polarity Maps through Multiparametric Microscopy

Autor: Emilio Garcia-Fernandez, Pilar Herrero-Foncubierta, Angel Orte, M. Carmen Gonzalez-Garcia

Publikováno v: Methods and Protocols
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Methods and Protocols, Vol 3, Iss 78, p 78 (2020)

M.C.G.-G. thanks MICIU/AEI for a predoctoral fellowship. We thank Juan M. Cuerva and Delia Miguel (University of Granada, Spain) for the synthesis of the acridone dyes, Rafael Salto and Maria D. Giron (University of Granada, Spain) for providing the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb91f6739d6af47cbf185d4b071fe89
https://pubmed.ncbi.nlm.nih.gov/33187290

miR-122 direct detection in human serum by time-gated fluorescence imaging

Autor: Cristina Ress, Juan J. Díaz-Mochón, Mario Antonio Fara, James W. Dear, Francisco Javier López-Delgado, Salvatore Pernagallo, Emilio Garcia-Fernandez, Angel Orte, M. Carmen Gonzalez-Garcia, Hugh Ilyine, Maria J. Ruedas-Rama

Publikováno v: Garcia-fernandez, E, Gonzalez-garcia, M C, Pernagallo, S, Ruedas-rama, M J, Fara, M A, López-delgado, F J, Dear, J W, Ilyine, H, Ress, C, Díaz-mochón, J J & Orte, A 2019, ' miR-122 direct detection in human serum by time-gated fluorescence imaging ', Chemical Communications, vol. 55, no. 99, pp. 14958-14961 . https://doi.org/10.1039/C9CC08069D
Chemical Communications

A simple method for direct detection of microRNAs (miRs) in human serum without the use of polymerase amplification is presented, achieving low miR-122 concentrations and importantly, discerning effectively single-base sequence mutations. The method

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df1dc592d42aafc389c5d2de96cf56f5
https://hdl.handle.net/20.500.11820/bbd9d9d0-c9e2-4ed0-9dc3-bf0807fd34e8

Orthogonal cell polarity imaging by multiparametric fluorescence microscopy

Autor: Emilio Garcia-Fernandez, Angel Orte, María D. Girón, Delia Miguel, Juan M. Cuerva, Amparo Navarro, Pilar Herrero-Foncubierta, Rafael Salto, Tomás Peña-Ruiz, M. Carmen Gonzalez-Garcia

Publikováno v: Sensors and Actuators B: Chemical. 309:127770

The cellular microenvironment is a complex medium due to high concentrations of proteins and an intertwined framework of cellular organelles. In particular, cellular micro-polarity controls several biological processes, since it modulates hydrophobic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5fd2e70995184203aed5cf18a0d01480
https://doi.org/10.1016/j.snb.2020.127770