Zobrazeno 1 - 10
of 111
pro vyhledávání: '"M. Candeias"'
Autor:
Thao-Nguyen Pham, Julie Coupey, Serge M. Candeias, Viktoriia Ivanova, Samuel Valable, Juliette Thariat
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-18 (2023)
Abstract Leucocyte subpopulations in both lymphoid and myeloid lineages have a significant impact on antitumor immune response. While radiation-induced lymphopenia is being studied extensively, radiation effects on lymphoid and myeloid subtypes have
Externí odkaz:
https://doaj.org/article/98d68dca379144a394142215b9e0bb87
Autor:
Melvin Pan, Christiane Zorbas, Maki Sugaya, Kensuke Ishiguro, Miki Kato, Miyuki Nishida, Hai-Feng Zhang, Marco M. Candeias, Akimitsu Okamoto, Takamasa Ishikawa, Tomoyoshi Soga, Hiroyuki Aburatani, Juro Sakai, Yoshihiro Matsumura, Tsutomu Suzuki, Christopher G. Proud, Denis L. J. Lafontaine, Tsuyoshi Osawa
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Small molecules that target RNA Polymerase I inhibit ribosome biogenesis to activate p53 through the nucleolar surveillance response pathway. Here, the authors show that p53 induction by ribosome stress is dependent on extracellular glutamine availab
Externí odkaz:
https://doaj.org/article/5a2c48021da748188909409721466a55
Autor:
Maria José López-Iniesta, Shrutee N. Parkar, Ana Catarina Ramalho, Rafaela Lacerda, Inês F. Costa, Jingyuan Zhao, Luísa Romão, Marco M. Candeias
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15844 (2022)
p53 is the most commonly mutated gene in human cancers. Two fundamental reasons for this are its long protein isoforms protect from cancer, while its shorter C-terminal isoforms can support cancer and metastasis. Previously, we have shown that the Δ
Externí odkaz:
https://doaj.org/article/422926380403453281d056f73898eb4e
Autor:
Shrutee N. Parkar, Maria José López-Iniesta, Ana Catarina Ramalho, Koto Kimura, Jingyuan Zhao, Filipa da Silva Rita, Luísa Romão, Marco M Candeias
p53is with little doubt one of the most powerful genes in our genome, as it makes growthvsarrest, repairvsreplacement, metabolismvsanabolism, lifevsdeath decisions in the cell. One wrong action and a healthy cell is lost or transforms into cancer. So
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81854d4e3e8d50c1fed7057750ec5aca
https://doi.org/10.1101/2023.04.07.536059
https://doi.org/10.1101/2023.04.07.536059
Autor:
Maria José López-Iniesta, Rafaela Lacerda, Ana Catarina Ramalho, Shrutee N. Parkar, Ana Marques-Ramos, Bruna Pereira, Lina Miyawaki, Jun Fujita, Roman Hrstka, Luísa Romão, Marco M Candeias
p53is the most known and studied tumour suppressor gene. Yet we have recently shown thatp53is also a proto-oncogene, as it encodes the Δ160p53 oncoprotein. Integrated stress response (ISR) is a survival pathway frequently activated in cancers, marke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b348b020483b02b0ece32c349f860411
https://doi.org/10.1101/2023.03.03.531004
https://doi.org/10.1101/2023.03.03.531004
Autor:
F. Marques, C. Vale, A. Rudnitskaya, C. Moreirinha, Lúcia Guilhermino, S. T. Costa, S. Joaquim, D. Matias, M. Candeias, Maria João Botelho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::723644eda29f2dc2888d238d4bb8790e
https://doi.org/10.2139/ssrn.4340463
https://doi.org/10.2139/ssrn.4340463
Publikováno v:
Peripheral nerve blocks.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::caec93475e14a6739b08d074502bbb99
https://doi.org/10.1136/rapm-2022-esra.182
https://doi.org/10.1136/rapm-2022-esra.182
Publikováno v:
Marine environmental research. 183
Marine litter represents a threat to the marine environment, being estimated that around eight million items are discarded daily in the ocean. Monitoring marine debris became a relevant topic of research as marine litter is one of the descriptors of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f5d0b52dbfaed631bdf7f219dba9b2c
https://pubmed.ncbi.nlm.nih.gov/36444794
https://pubmed.ncbi.nlm.nih.gov/36444794
Autor:
Melvin Pan, Christiane Zorbas, Maki Sugaya, Kensuke Ishiguro, Miki Kato, Miyuki Nishida, Hai-Feng Zhang, Marco M Candeias, Akimitsu Okamoto, Takamasa Ishikawa, Tomoyoshi Soga, Hiroyuki Aburatani, Juro Sakai, Yoshihiro Matsumura, Tsutomu Suzuki, Christopher G. Proud, Denis L. J. Lafontaine, Tsuyoshi Osawa
SummaryRibosome biogenesis involves the processing of precursor ribosomal RNAs (pre-rRNAs) and sequential assembly with ribosomal proteins. Here we report that nutrient deprivation severely impairs pre-rRNA processing and leads to the accumulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e4870a7eb9451f853334ddf263914a1
https://doi.org/10.1101/2021.12.03.471189
https://doi.org/10.1101/2021.12.03.471189
Autor:
Melvin Pan, Christiane Zorbas, Maki Sugaya, Kensuke Ishiguro, Miki Kato, Miyuki Nishida, Hai-Feng Zhang, Marco M. Candeias, Akimitsu Okamoto, Takamasa Ishikawa, Tomoyoshi Soga, Hiroyuki Aburatani, Juro Sakai, Yoshihiro Matsumura, Tsutomu Suzuki, Christopher G. Proud, Denis L. J. Lafontaine, Tsuyoshi Osawa
Publikováno v:
Nature communications. 13(1)
Ribosome biogenesis is an energetically expensive program that is dictated by nutrient availability. Here we report that nutrient deprivation severely impairs precursor ribosomal RNA (pre-rRNA) processing and leads to the accumulation of unprocessed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eb7b5cdc3a2411f369f783f77b97c8c
https://pubmed.ncbi.nlm.nih.gov/35764642
https://pubmed.ncbi.nlm.nih.gov/35764642