Zobrazeno 1 - 10
of 1 637
pro vyhledávání: '"M. CHIARIELLO"'
Autor:
Andrea M. Chiariello, Alex Abraham, Simona Bianco, Andrea Esposito, Andrea Fontana, Francesca Vercellone, Mattia Conte, Mario Nicodemi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract SARS-CoV-2 can re-structure chromatin organization and alter the epigenomic landscape of the host genome, but the mechanisms that produce such changes remain unclear. Here, we use polymer physics to investigate how the chromatin of the host
Externí odkaz:
https://doaj.org/article/34229b608a134e5c8d7dae241dafcf19
Autor:
Giuseppina Divisato, Andrea M. Chiariello, Andrea Esposito, Pietro Zoppoli, Federico Zambelli, Maria Antonietta Elia, Graziano Pesole, Danny Incarnato, Fabiana Passaro, Silvia Piscitelli, Salvatore Oliviero, Mario Nicodemi, Silvia Parisi, Tommaso Russo
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-19 (2022)
Abstract Background The high-mobility group Hmga family of proteins are non-histone chromatin-interacting proteins which have been associated with a number of nuclear functions, including heterochromatin formation, replication, recombination, DNA rep
Externí odkaz:
https://doaj.org/article/38fcea0f86634863945360abb9ae8a17
Autor:
Mattia Conte, Ehsan Irani, Andrea M. Chiariello, Alex Abraham, Simona Bianco, Andrea Esposito, Mario Nicodemi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Two main mechanisms have been proposed to shape 3D genome architecture - loop extrusion and phase separation. Here the authors combine these mechanisms in polymer models in a manner that best fits 3D genome, based on both Hi-C and super-resolution lo
Externí odkaz:
https://doaj.org/article/5970e283afc74da1b576894812c227e8
Autor:
Mattia Conte, Luca Fiorillo, Simona Bianco, Andrea M. Chiariello, Andrea Esposito, Mario Nicodemi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The molecular and physical mechanisms underlying chromatin folding at the single DNA molecule level remain poorly understood. Here, the authors use polymer modeling to investigate the conformations of two 2Mb-wide DNA loci in normal and cohesin deple
Externí odkaz:
https://doaj.org/article/83550059761641128b264d751599f703
Autor:
Mattia Conte, Andrea M. Chiariello, Alex Abraham, Simona Bianco, Andrea Esposito, Mario Nicodemi, Tommaso Matteuzzi, Francesca Vercellone
Publikováno v:
Algorithms, Vol 15, Iss 9, p 330 (2022)
Recent super-resolution imaging technologies enable tracing chromatin conformation with nanometer-scale precision at the single-cell level. They revealed, for example, that human chromosomes fold into a complex three-dimensional structure within the
Externí odkaz:
https://doaj.org/article/90a28e8cd81a410caf0cdfbbaf6fac64
Autor:
Irene Salamon, Simone Serio, Simona Bianco, Christina Pagiatakis, Silvia Crasto, Andrea M. Chiariello, Mattia Conte, Paola Cattaneo, Luca Fiorillo, Arianna Felicetta, Elisa di Pasquale, Paolo Kunderfranco, Mario Nicodemi, Roberto Papait, Gianluigi Condorelli
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101539- (2020)
Summary: Enhancer RNAs (eRNAs) are a subset of long noncoding RNA generated from genomic enhancers: they are thought to act as potent promoters of the expression of nearby genes through interaction with the transcriptional and epigenomic machineries.
Externí odkaz:
https://doaj.org/article/1c45108cf33d43c585a27b5c9e5e722c
Autor:
Andrea M. Chiariello, Simona Bianco, A. Marieke Oudelaar, Andrea Esposito, Carlo Annunziatella, Luca Fiorillo, Mattia Conte, Alfonso Corrado, Antonella Prisco, Martin S.C. Larke, Jelena M. Telenius, Renato Sciarretta, Francesco Musella, Veronica J. Buckle, Douglas R. Higgs, Jim R. Hughes, Mario Nicodemi
Publikováno v:
Cell Reports, Vol 30, Iss 7, Pp 2125-2135.e5 (2020)
Summary: We investigate the three-dimensional (3D) conformations of the α-globin locus at the single-allele level in murine embryonic stem cells (ESCs) and erythroid cells, combining polymer physics models and high-resolution Capture-C data. Model p
Externí odkaz:
https://doaj.org/article/0c35df1eab8b4232bbec792059516f82
Akademický článek
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Autor:
Fabrizio Tafuri, Andrea M. Chiariello
Publikováno v:
The European Physical Journal Plus. 138
The coil-globule transition of hetero-polymer chains is studied here. By means of extensive Molecular Dynamics simulations, we show that the transition is directly linked to the complexity of the chain, which depends on the number of chemical species
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::301431d7be454a29d25c0ba903dfb6ec
https://doi.org/10.1140/epjp/s13360-023-03776-x
https://doi.org/10.1140/epjp/s13360-023-03776-x
Autor:
Mattia Conte, Andrea M. Chiariello, Simona Bianco, Andrea Esposito, Alex Abraham, Mario Nicodemi
Publikováno v:
Methods in Molecular Biology ISBN: 9781071631423
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d629292710d7512480a574d4f5375be
https://doi.org/10.1007/978-1-0716-3143-0_5
https://doi.org/10.1007/978-1-0716-3143-0_5
