Zobrazeno 1 - 10
of 81
pro vyhledávání: '"M. C. Willingham"'
Publikováno v:
APOPTOSIS. 3:439-449
A variety of chemotherapeutic agents induce cell death via apoptosis. We had shown previously that gemcitabine (2′,2′-difluorodeoxycytidine) induced an atypical apoptosis in BG-1 human ovarian cancer cells; therefore, further studies were conduct
Autor:
R W Kozak, H Lorberboum-Galski, L Jones, R K Puri, M C Willingham, T Malek, D J Fitzgerald, T A Waldmann, I Pastan
Publikováno v:
The Journal of Immunology. 145:2766-2771
A number of different immunotherapeutic reagents are currently being developed to target IL-2R for the treatment of leukemia, graft rejection, and certain autoimmune diseases. Previously, we have shown that IL-2-PE40, a chimeric protein composed of h
Publikováno v:
Apoptosis : an international journal on programmed cell death. 3(6)
A variety of chemotherapeutic agents induce cell death via apoptosis. We had shown previously that gemcitabine (2',2'-difluorodeoxycytidine) induced an atypical apoptosis in BG-1 human ovarian cancer cells; therefore, further studies were conducted t
Publikováno v:
Journal of lipid research. 41(12)
Two closely related enzymes with more than 50% sequence identity have been identified that catalyze the esterification of cholesterol using acyl-CoA substrates, namely acyl-CoA:cholesterol acyltransferase 1 (ACAT1) and ACAT2. Both are membrane-spanni
Autor:
L H, Pai-Scherf, J A, Carrasquillo, C, Paik, O, Gansow, M, Whatley, D, Pearson, K, Webber, M, Hamilton, C, Allegra, M, Brechbiel, M C, Willingham, I, Pastan
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 6(5)
B3 is a murine monoclonal antibody (mAb) that recognizes a LewisY carbohydrate antigen present on the surface of many carcinomas. An imaging and Phase I trial was performed to study the ability of 111In-mAb B3 to image known metastasis and determine
Autor:
A J, Trimboli, B M, Waite, G, Atsumi, A N, Fonteh, A M, Namen, C E, Clay, T E, Kute, K P, High, M C, Willingham, F H, Chilton
Publikováno v:
Cancer research. 59(24)
Recent studies have demonstrated that arachidonic acid (AA) may serve as an important signal that blocks cell proliferation of certain neoplastic cells. The current study was conducted to determine whether disruption of AA homeostasis influences brea
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 5(9)
To exploit overexpression of erbB2 in human cancers, we constructed a single-chain immunotoxin (erb-38) that contains the Fv portion of monoclonal antibody e23 fused to a truncated form of Pseudomonas exotoxin A. In a Phase I study, five breast cance
Autor:
N L, Jones, M C, Willingham
Publikováno v:
The Anatomical record. 255(1)
Macrophage foam cell formation in vitro requires uptake of modified low density lipoproteins (LDL) such as acetylated LDL (AcLDL) and moderately oxidized LDL (OxLDL). Macrophages incubated with AcLDL and OxLDL, but not LDL, showed increased membrane
Publikováno v:
The Anatomical record. 255(1)
Macrophage foam cell formation in vitro requires uptake of modified low density lipoproteins (LDL) such as acetylated LDL (AcLDL) and moderately oxidized LDL (OxLDL), or beta-migrating very low density lipoprotein (betaVLDL), a naturally occurring li
Autor:
M C, Willingham
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 115