Výsledky vyhledávání - "M. C. Underwood"

Thermodynamic Linkage between the S1 Site, the Na+ Site, and the Ca2+ Site in the Protease Domain of Human Activated Protein C (APC)

Autor: Kaillathe Padmanabhan, M. C. Underwood, Amy E. Schmidt, Wolfram Bode, S P Bajaj, Timothy Mather

Publikováno v: Journal of Biological Chemistry. 277:28987-28995

The serine protease domain of activated protein C (APC) contains a Na+ and a Ca2+ site. However, the number and identity of the APC residues that coordinate to Na+ is not precisely known. Further, the functional link between the Na+ and the Ca2+ site

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::099ebab0e63a019c793e54b5655d02ff
https://doi.org/10.1074/jbc.m201892200

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Thermodynamic linkage between the S1 site, the Na+ site, and the Ca2+ site in the protease domain of human coagulation factor xa. Studies on catalytic efficiency and inhibitor binding

Autor: M C, Underwood, D, Zhong, A, Mathur, T, Heyduk, S P, Bajaj

Publikováno v: The Journal of biological chemistry. 275(47)

The serine protease domain of factor Xa (FXa) contains a sodium as well as a calcium-binding site. Here, we investigated the functional significance of these two cation-binding sites and their thermodynamic links to the S1 site. Kinetic data reveal t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6dd3ca718b553d459613101fa288a4cc
https://pubmed.ncbi.nlm.nih.gov/10973949

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Assessing the indoor air impact from a hazardous waste site: a case study

Autor: M C, Underwood

Publikováno v: Toxicology and industrial health. 12(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::21792af58550e0d8c11e4221d0d4cef4
https://pubmed.ncbi.nlm.nih.gov/8794531

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Specifically designed thiosteroids as active-site-directed probes for functional dissection of rat liver cytochrome P450 3A isozymes

Autor: M. C. Underwood, John R. Cashman, Maria Almira Correia

Publikováno v: Chemical research in toxicology. 5(1)

Testosterone (T) 6 beta-hydroxylase (6 beta-OHase) is a well-recognized functional marker of rat liver cytochrome P450 3A (P450 3A) isozymes. Pretreatment of rats with inducers or specific or nonspecific inhibitors of P450 3A isozymes is associated n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bf8563090882163b21eb83214b5a13b
https://pubmed.ncbi.nlm.nih.gov/1581535

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Bulk material analysis using 14 MeV neutrons

Autor: J. S. Petler, K. Randle, M. C. Underwood

Publikováno v: Journal of Radioanalytical and Nuclear Chemistry Articles. 113:383-390

There is considerable interest in bulk material analysis using energetic neutrons e.g. on-line coal analysis and down-hole logging. Recent work has indicated that an in-situ analysis of all the major elements of coal, using prompt capture and inelast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::914c5a5b20fc5cec71c3ed2d3e3285eb
https://doi.org/10.1007/bf02050511

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High resolution prompt (n,γ) spectroscopy using a down hole logging tool

Autor: J. S. Petler, M. C. Underwood

Publikováno v: Journal of Radioanalytical and Nuclear Chemistry Articles. 114:379-385

A down-hole logging tool is described utilising a 5 Ci241Am−Be neutron source and intrinsic germanium gamma-ray detector. The tool was used to measure the prompt gamma-ray response from the irradiation of 4 well characterised coal samples. The corr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fdd980491b79ea45c57403f0eda055ec
https://doi.org/10.1007/bf02039813

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The Applications of an Integral Plume Rise Model

Autor: S. Buchner, M. C. Underwood

Publikováno v: Air Pollution Modeling and Its Application III ISBN: 9781461296737

The mathematical description of plume rise is well established and has been reviewed by Briggs1. As the ground level concentration of pollutants is a strong function of the effective rise of the plume above the chimney, Δh, it is important that this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::106dd77e6cdab2a434dcc1b9008a12aa
https://doi.org/10.1007/978-1-4613-2691-5_44

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Inactivation of rat hepatic cytochrome P-450 by spironolactone

Autor: M. C. Underwood, Katsumi Sugiyama, Maria Almira Correia, Caroline J. Decker

Publikováno v: Biochemical and biophysical research communications. 136(3)

Administration of antimineralocorticoid spironolactone (SPL) to rats results in modest destruction of hepatic cytochrome P-450 with parallel loss of heme. This process is accentuated by pretreatment with dexamethasone (DEX), an inducer of cytochrome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b896fb5f774a61ebe420bbcb5b544b4
https://pubmed.ncbi.nlm.nih.gov/3487316

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