Zobrazeno 1 - 10
of 25
pro vyhledávání: '"M. C. O'Donovan"'
Autor:
S. I. Dimitriadis, G. Perry, S. F. Foley, K. E. Tansey, D. K. Jones, P. Holmans, S. Zammit, J. Hall, M. C. O’Donovan, M. J. Owen, K. D. Singh, D. E. Linden
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Gamma oscillations (30–90 Hz) have been proposed as a signature of cortical visual information processing, particularly the balance between excitation and inhibition, and as a biomarker of neuropsychiatric diseases. Magnetoencephalography
Externí odkaz:
https://doaj.org/article/04d7fcdfd1884d62becdc5bcbe76590d
Autor:
K. Crawford, G. Leonenko, E. Baker, D. Grozeva, B. Lan-Leung, P. Holmans, J. Williams, M. C. O’Donovan, V. Escott-Price, DK. Ivanov
Polygenic risk scores (PRS) have been widely adopted as a tool for measuring common variant liability and it has been shown to predict lifetime risk of Alzheimer’s disease (AD) development. However, the relationship between PRS and AD pathogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eee2ceaf02daa5061c37c6869be8f245
https://doi.org/10.1101/2022.06.29.22276952
https://doi.org/10.1101/2022.06.29.22276952
Autor:
S I Dimitriadis, G Perry, T M Lancaster, K E Tansey, K D Singh, P Holmans, A Pocklington, G Davey Smith, S Zammit, J Hall, M C O’Donovan, M J Owen, D K Jones, D E Linden
Publikováno v:
Cerebral Cortex, 33:bhac256, 2997-3011. Oxford University Press
Dimitriadis, S L, Perry, G, Lancaster, T, Tansey, K, Singh, K D, Holmans, P, Pocklington, A, Davey Smith, G, Zammit, S, Hall, J, O'Donovan, M C, Owen, MJ, Jones, D K & Linden, DE 2022, ' Genetic risk for schizophrenia is associated with increased proportion of indirect connections in brain networks revealed by a semi-metric analysis : Evidence from population sample stratified for polygenic risk ', Cerebral Cortex . https://doi.org/10.1093/cercor/bhac256
Dimitriadis, S L, Perry, G, Lancaster, T, Tansey, K, Singh, K D, Holmans, P, Pocklington, A, Davey Smith, G, Zammit, S, Hall, J, O'Donovan, M C, Owen, MJ, Jones, D K & Linden, DE 2022, ' Genetic risk for schizophrenia is associated with increased proportion of indirect connections in brain networks revealed by a semi-metric analysis : Evidence from population sample stratified for polygenic risk ', Cerebral Cortex . https://doi.org/10.1093/cercor/bhac256
Research studies based on tractography have revealed a prominent reduction of asymmetry in some key white-matter tracts in schizophrenia (SCZ). However, we know little about the influence of common genetic risk factors for SCZ on the efficiency of ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bfa0fe20520b86b5351b76d5506a230
Autor:
K. J. S. Lewis, K. Tilling, K. Gordon-Smith, K. E. A. Saunders, A. Di Florio, L. Jones, I. Jones, M. C. O'Donovan, J. Heron
Publikováno v:
Lewis, K, Tilling, K M, Gordon-Smith, K, Saunders, K, Florio, A D, Jones, L, Jones, I, O'Donovan, M & Heron, J E 2023, ' The dynamic interplay between sleep and mood : an intensive longitudinal study of individuals with bipolar disorder ', Psychological Medicine, vol. 53, no. 8, pp. 3345-3354 . https://doi.org/10.1017/S0033291721005377
Print: 0033-2917
Print: 0033-2917
Background Sleep disturbances are important symptoms to monitor in people with bipolar disorder (BD) but the precise longitudinal relationships between sleep and mood remain unclear. We aimed to examine associations between stable and dynamic aspects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16952277906ff12e6280b203a14d9c60
https://pubmed.ncbi.nlm.nih.gov/35074035
https://pubmed.ncbi.nlm.nih.gov/35074035
Autor:
N E, Clifton, A J, Pocklington, B, Scholz, E, Rees, J T R, Walters, G, Kirov, M C, O'Donovan, M J, Owen, L S, Wilkinson, K L, Thomas, J, Hall
Publikováno v:
Molecular Psychiatry
Large-scale genomic studies have made major progress in identifying genetic risk variants for schizophrenia. A key finding from these studies is that there is an increased burden of genomic copy number variants (CNVs) in schizophrenia cases compared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a5be5155d1c20db17b68a7e04a2ca8a4
https://pubmed.ncbi.nlm.nih.gov/27956746
https://pubmed.ncbi.nlm.nih.gov/27956746
Autor:
G, Hudson, R, Sims, D, Harold, J, Chapman, P, Hollingworth, A, Gerrish, G, Russo, M, Hamshere, V, Moskvina, N, Jones, C, Thomas, A, Stretton, P A, Holmans, M C, O'Donovan, M J, Owen, J, Williams, P F, Chinnery, Julie, Williams
Publikováno v:
Neurology. 78:1038-1042
Objective: Although several studies have described an association between Alzheimer disease (AD) and genetic variation of mitochondrial DNA (mtDNA), each has implicated different mtDNA variants, so the role of mtDNA in the etiology of AD remains unce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ddb727895b15695a919baa8ccf735c
https://doi.org/10.1212/wnl.0b013e31824e8f1d
https://doi.org/10.1212/wnl.0b013e31824e8f1d
Autor:
A L, Richards, G, Leonenko, J T, Walters, D H, Kavanagh, E G, Rees, A, Evans, K D, Chambert, J L, Moran, J, Goldstein, B M, Neale, S A, McCarroll, A J, Pocklington, P A, Holmans, M J, Owen, M C, O'Donovan
Publikováno v:
Human Molecular Genetics
Schizophrenia is a highly heritable disorder. Genome-wide association studies based largely on common alleles have identified over 100 schizophrenia risk loci, but it is also evident from studies of copy number variants (CNVs) and from exome-sequenci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b9c3c5cb7f36529f8d1b718f8b7699ae
https://pubmed.ncbi.nlm.nih.gov/26740555
https://pubmed.ncbi.nlm.nih.gov/26740555
Neuropsychological effects of the CSMD1 genome-wide associated schizophrenia risk variant rs10503253
Autor:
G, Donohoe, J, Walters, A, Hargreaves, E J, Rose, D W, Morris, C, Fahey, S, Bellini, E, Cummins, I, Giegling, A M, Hartmann, H-J, Möller, P, Muglia, M J, Owen, M, Gill, M C, O'Donovan, D, Tropea, D, Rujescu, A, Corvin
Publikováno v:
Genes, brain, and behavior. 12(2)
The single-nucleotide polymorphism (SNP) rs10503253, located within the CUB and Sushi multiple domains-1 (CSMD1) gene on 8p23.2, was recently identified as genome-wide significant for schizophrenia (SZ), but is of unknown function. We investigated th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::07aaf97a3346b598fc497d69872e23c5
https://pubmed.ncbi.nlm.nih.gov/23320435
https://pubmed.ncbi.nlm.nih.gov/23320435
Publikováno v:
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. (1)
We have followed up the extensive replicated evidence that the dopamine DRD4 receptor is involved in the aetiology of ADHD by undertaking direct analysis of genes encoding other proteins in this effector system. We prioritised the genes encoding G pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::afcf29c011efbe9ddd1c921a03a56f63
https://pubmed.ncbi.nlm.nih.gov/15108183
https://pubmed.ncbi.nlm.nih.gov/15108183
Autor:
N J, Bray, G, Kirov, R J, Owen, N J, Jacobsen, L, Georgieva, H J, Williams, N, Norton, G, Spurlock, S, Jones, S, Zammit, M C, O'Donovan, M J, Owen
Publikováno v:
Genes, brain, and behavior. 1(3)
Abnormalities in synaptic connectivity and plasticity have been implicated in the pathophysiology of schizophrenia. Molecules involved in the development and maintenance of neural circuitry include the recently cloned protocadherins. Human protocadhe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4eebc2a0302201d08df68c09889e1596
https://pubmed.ncbi.nlm.nih.gov/12884975
https://pubmed.ncbi.nlm.nih.gov/12884975