Genetic risk for schizophrenia is associated with altered visually-induced gamma band activity: evidence from a population sample stratified polygenic risk

Autor: S. I. Dimitriadis, G. Perry, S. F. Foley, K. E. Tansey, D. K. Jones, P. Holmans, S. Zammit, J. Hall, M. C. O’Donovan, M. J. Owen, K. D. Singh, D. E. Linden

Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)

Abstract Gamma oscillations (30–90 Hz) have been proposed as a signature of cortical visual information processing, particularly the balance between excitation and inhibition, and as a biomarker of neuropsychiatric diseases. Magnetoencephalography

Externí odkaz: https://doaj.org/article/04d7fcdfd1884d62becdc5bcbe76590d

Genetic risk for schizophrenia is associated with increased proportion of indirect connections in brain networks revealed by a semi-metric analysis: Evidence from population sample stratified for polygenic risk

Autor: S I Dimitriadis, G Perry, T M Lancaster, K E Tansey, K D Singh, P Holmans, A Pocklington, G Davey Smith, S Zammit, J Hall, M C O’Donovan, M J Owen, D K Jones, D E Linden

Publikováno v: Cerebral Cortex, 33:bhac256, 2997-3011. Oxford University Press
Dimitriadis, S L, Perry, G, Lancaster, T, Tansey, K, Singh, K D, Holmans, P, Pocklington, A, Davey Smith, G, Zammit, S, Hall, J, O'Donovan, M C, Owen, MJ, Jones, D K & Linden, DE 2022, ' Genetic risk for schizophrenia is associated with increased proportion of indirect connections in brain networks revealed by a semi-metric analysis : Evidence from population sample stratified for polygenic risk ', Cerebral Cortex . https://doi.org/10.1093/cercor/bhac256

Research studies based on tractography have revealed a prominent reduction of asymmetry in some key white-matter tracts in schizophrenia (SCZ). However, we know little about the influence of common genetic risk factors for SCZ on the efficiency of ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bfa0fe20520b86b5351b76d5506a230

Schizophrenia copy number variants and associative learning

Autor: N E, Clifton, A J, Pocklington, B, Scholz, E, Rees, J T R, Walters, G, Kirov, M C, O'Donovan, M J, Owen, L S, Wilkinson, K L, Thomas, J, Hall

Publikováno v: Molecular Psychiatry

Large-scale genomic studies have made major progress in identifying genetic risk variants for schizophrenia. A key finding from these studies is that there is an increased burden of genomic copy number variants (CNVs) in schizophrenia cases compared

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a5be5155d1c20db17b68a7e04a2ca8a4
https://pubmed.ncbi.nlm.nih.gov/27956746

Somatic mosaicism in schizophrenia brains reveals prenatal mutational processes.

Autor: Maury, Eduardo A.^1,2,3, Jones, Attila^4,5, Seplyarskiy, Vladimir^6,7, Nguyen, Thanh Thanh L.^8,9, Rosenbluh, Chaggai⁵, Taejong Bae¹⁰, Yifan Wang¹⁰, Abyzov, Alexej¹⁰, Khoshkhoo, Sattar^2,11, Chahine, Yasmine^1,11, Sijing Zhao², Venkatesh, Sanan⁴, Root, Elise⁹, Voloudakis, Georgios¹², Roussos, Panagiotis¹², Park, Peter J.⁷, Akbarian, Schahram^13,14, Brennand, Kristen^8,9, Reilly, Steven⁹, Lee, Eunjung A.^1,2

Publikováno v: Science. 10/11/2024, Vol. 386 Issue 6718, p217-224. 8p. 5 Color Photographs.

Exome arrays capture polygenic rare variant contributions to schizophrenia

Autor: A L, Richards, G, Leonenko, J T, Walters, D H, Kavanagh, E G, Rees, A, Evans, K D, Chambert, J L, Moran, J, Goldstein, B M, Neale, S A, McCarroll, A J, Pocklington, P A, Holmans, M J, Owen, M C, O'Donovan

Publikováno v: Human Molecular Genetics

Schizophrenia is a highly heritable disorder. Genome-wide association studies based largely on common alleles have identified over 100 schizophrenia risk loci, but it is also evident from studies of copy number variants (CNVs) and from exome-sequenci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b9c3c5cb7f36529f8d1b718f8b7699ae
https://pubmed.ncbi.nlm.nih.gov/26740555