Zobrazeno 1 - 10
of 23
pro vyhledávání: '"M. C. Miceli"'
Publikováno v:
The Journal of Immunology. 165:3722-3729
Galectin-1 is an endogenous lectin with known T cell immunoregulatory activity, though the molecular basis by which galectin-1 influences Ag specific T cell responses has not been elucidated. Here, we characterize the ability of galectin-1 to modulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::782fdeace9193e674a012bf274952278
https://doi.org/10.4049/jimmunol.165.7.3722
https://doi.org/10.4049/jimmunol.165.7.3722
Publikováno v:
The Journal of Immunology. 159:2292-2300
The lymphocyte-specific tyrosine kinase Lck is essential for TCR-mediated signal transduction. This is in part due to its enzymatic activity as a tyrosine kinase responsible for TCR-induced tyrosine phosphorylation of zeta and CD3 receptor subunits.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::041223869b188e3a5f20807b4315f772
https://doi.org/10.4049/jimmunol.159.5.2292
https://doi.org/10.4049/jimmunol.159.5.2292
Publikováno v:
The Journal of Immunology. 159:1758-1766
The T cell hybridoma BI-141 has been previously used to dissect the roles of Lck in Ag-induced IL-2 production. Here we demonstrate that BI-141 undergoes apoptosis in response to TCR stimulation using Ag or anti-TCR Abs. Using a panel of BI-141 trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbf08f2c0939c7103b6baa5829ddbf7c
https://doi.org/10.4049/jimmunol.159.4.1758
https://doi.org/10.4049/jimmunol.159.4.1758
Publikováno v:
The Journal of Immunology. 149:880-886
Lyb-2/CD72 is a 45-kDa mouse B cell surface protein that binds CD5 and has been shown to play a role in B cell proliferation and differentiation. Using the polymerase chain reaction we have isolated and sequenced cDNA clones encoding the serologicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18e7750fe94ac5497f1eb3239d6438c8
https://doi.org/10.4049/jimmunol.149.3.880
https://doi.org/10.4049/jimmunol.149.3.880
Publikováno v:
Proceedings of the National Academy of Sciences. 88:2623-2627
CD4 and CD8 play an important role in T-cell recognition and activation; however, their mechanisms of action are not well understood. We compare the effects of expressing CD4 and CD8 alpha either individually or together in a class II-restricted T-ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f228479a8aa247bd94520b2a3ce52e75
https://doi.org/10.1073/pnas.88.7.2623
https://doi.org/10.1073/pnas.88.7.2623
Publikováno v:
Nature. 350:62-66
Lymphocyte-specific tyrosine protein kinase p56lck is physically associated with CD4 and CD8 T-cell surface molecules, suggesting that it may transduce CD4/CD8-triggered tyrosine phosphorylation signals during antigen stimulation. Indeed, antibody-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10dc31a75addccfa9d7412192712f530
https://doi.org/10.1038/350062a0
https://doi.org/10.1038/350062a0
Publikováno v:
Seminars in immunology. 13(2)
T cell receptor (TCR) antigen recognition induces the formation of a specialized 'immunological synapse' at the T cell : antigen presenting cell (APC) junction. This junction is generated by the recruitment and exclusion of particular proteins from t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac09388cf7339ba53099a60fc1bc06a
https://pubmed.ncbi.nlm.nih.gov/11308295
https://pubmed.ncbi.nlm.nih.gov/11308295
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(2)
Galectin-1 is an endogenous lectin expressed by thymic and lymph node stromal cells at sites of Ag presentation and T cell death during normal development. It is known to have immunomodulatory activity in vivo and can induce apoptosis in thymocytes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f7b186ea0c218a7e67a65da2e3040202
https://pubmed.ncbi.nlm.nih.gov/9916701
https://pubmed.ncbi.nlm.nih.gov/9916701
Autor:
M, Moran, M C, Miceli
Publikováno v:
Immunity. 9(6)
GPI-linked proteins coassociate with intracellular tyrosine kinases in "lipid rafts" proposed to function as platforms for signal transduction and cytoskeletal reorganization. TCR activation requires both tyrosine kinase signals and cytoskeletal reor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d7da4addd76e28ea0f22df06614be51f
https://pubmed.ncbi.nlm.nih.gov/9881969
https://pubmed.ncbi.nlm.nih.gov/9881969
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 159(5)
The lymphocyte-specific tyrosine kinase Lck is essential for TCR-mediated signal transduction. This is in part due to its enzymatic activity as a tyrosine kinase responsible for TCR-induced tyrosine phosphorylation of zeta and CD3 receptor subunits.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f61fa6ed6fc2d1ddcd30ea6bb8421f7d
https://pubmed.ncbi.nlm.nih.gov/9278318
https://pubmed.ncbi.nlm.nih.gov/9278318