Výsledky vyhledávání - "M. C. M. Verschuren"

Identification of a new cluster of T-cell receptor delta recombining elements

Autor: Christian Schmidt, M. C. M. Verschuren, Stephan Serke, Jens Wanzeck, Grzegorz K. Przybylski, Jacques J.M. van Dongen

Publikováno v: Immunology, 108, 16-23. Wiley-Blackwell Publishing Ltd

Within the human T-cell receptor delta (TCRD) gene we have identified a new cluster of seven delta recombining elements (deltaRec2.1-2.7), located 2.6-5.2 kilobases downstream of the Vdelta2 gene segment. The deltaRec2 elements are isolated recombini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68351dce93755ec30f86d9f246f41f8d
https://doi.org/10.1046/j.1365-2567.2003.01544.x

Zobrazit plný text záznamu

Psoriatic lesional skin exhibits an aberrant expression pattern of interferon regulatory factor-2 (IRF-2)

Autor: Jon D. Laman, M. C. M. Verschuren, Errol P. Prens, Leslie van der Fits, Leontine I van der Wel

Publikováno v: Journal of Pathology, 199, 107-114. John Wiley & Sons Ltd.

Psoriasis is a T-cell-mediated inflammatory skin disease. A Th1 cytokine profile with increased levels of interferon-gamma (IFN-gamma) is predominant in skin and peripheral blood mononuclear cells (PBMCs) from psoriasis patients. Furthermore, psoriat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6434b3dcd14b7202897724359de3969c
https://hdl.handle.net/1765/64387

Zobrazit plný text záznamu

A single split-signal FISH probe set allows detection of TAL1translocations as well as SIL-TAL1 fusion genes in a single test

Autor: M Dib, Barbara H. Barendregt, M.E.L. van der Burg, B Smit, H B Beverloo, J. J. M. Van Dongen, Anthonie Willem Langerak, Bas Brinkhof, M. C. M. Verschuren

Publikováno v: Leukemia. 16:755-761

About 30% of T cell acute lymphoblastic leukemias (T-ALL) carry TAL1 gene aberrations. In the majority of cases (approximately 25%), this concerns a submicroscopic deletion of approximately 90 kb in chromosome region 1p32, which deletes the coding re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0633b8ffdb729d5ce2735507b2e25b
https://doi.org/10.1038/sj.leu.2402432

Zobrazit plný text záznamu

T cell receptor excision circles as markers for recent thymic emigrants: basic aspects, technical approach, and guidelines for interpretation

Autor: M. C. M. Verschuren, Mette D. Hazenberg, Dörte Hamann, Jacques J.M. van Dongen, Frank Miedema

Publikováno v: Journal of Molecular Medicine, 79, 631-640. Springer-Verlag

T cell differentiation in the thymus is characterized by a hierarchical order of rearrangement steps in the T cell receptor (TCR) genes, resulting in the joining of V, D, and J gene segments. During each of the rearrangement steps, DNA fragments betw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5181594a5345b2e9661e53dccfb11aa2
https://doi.org/10.1007/s001090100271

Zobrazit plný text záznamu

Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection

Autor: J J van Dongen, R.J. de Boer, Mette D. Hazenberg, Dörte Hamann, Jan C. C. Borleffs, Frank Miedema, Aster Tsegaye, J.W. Cohen Stuart, Charles A. Boucher, T F Rinke de Wit, R. A. Coutinho, Lange Jm, Sigrid A. Otto, M. C. M. Verschuren

Publikováno v: Nature Medicine, 6(8), 1036-1042. Nature Publishing Group
Nature medicine, 6(8), 1036. Nature America
Nature medicine, 6(9), 1036-1042. Nature Publishing Group

Recent thymic emigrants can be identified by T cell receptor excision circles (TRECs) formed during T-cell receptor rearrangement. Decreasing numbers of TRECs have been observed with aging and in human immunodeficiency virus (HIV)-1 infected individu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485e19a5671785366a7c8b8d870eaa6e
https://pure.eur.nl/en/publications/adebfd16-01e5-4cb9-a582-444d3140f248

Zobrazit plný text záznamu

Disruption of αβ but not of γδ T cell development by overexpression of the helix–loop–helix protein Id3 in committed T cell progenitors

Autor: H. Spits, P Res, Franka Couwenberg, Bianca Blom, M. C. M. Verschuren, Alexander P.A. Stegmann, Mirjam H.M. Heemskerk, A. Q. Bakker, J. J. M. Van Dongen

Publikováno v: The EMBO Journal. 18:2793-2802

Enforced expression of Id3, which has the capacity to inhibit many basic helix-loop-helix (bHLH) transcription factors, in human CD34(+) hematopoietic progenitor cells that have not undergone T cell receptor (TCR) gene rearrangements inhibits develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::850d5664451472461b5d36d4f2310af7
https://doi.org/10.1093/emboj/18.10.2793

Zobrazit plný text záznamu

TCR Gene Rearrangements and Expression of the Pre-T Cell Receptor Complex During Human T-Cell Differentiation

Autor: Ingrid L. M. Wolvers-Tettero, A. Q. Bakker, M. C. M. Verschuren, Bianca Blom, J. J. M. Van Dongen, H. Spits, E. J. Van Gastel-Mol, Mirjam H.M. Heemskerk

Publikováno v: Blood. 93:3033-3043

Recent studies have identified several populations of progenitor cells in the human thymus. The hematopoietic precursor activity of these populations has been determined. The most primitive human thymocytes express high levels of CD34 and lack CD1a.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::976030c2b027385e08de50f1a77ec0e7
https://doi.org/10.1182/blood.v93.9.3033

Zobrazit plný text záznamu

Early stages in the development of human T, natural killer and thymic dendritic cells

Autor: A C Jaleco, P Res, Kees Weijer, Mirjam H.M. Heemskerk, J. J. M. Van Dongen, Hergen Spits, Bianca Blom, M. C. M. Verschuren

Publikováno v: Immunological Reviews, 165, 75-86. Wiley-Blackwell Publishing Ltd

T-cell development is initiated when CD34+ pluripotent stem cells or their immediate progeny leave the bone marrow to migrate to the thymus. Upon arrival in the thymus the stem cell progeny is not yet committed to the T-cell lineage as it has the cap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b279d7e95f97d5aec65385993312bb4b
https://doi.org/10.1111/j.1600-065x.1998.tb01231.x

Zobrazit plný text záznamu

T-cell receptor Vδ-Jα rearrangements in human thymocytes: the role of Vδ-Jα rearrangements in T-cell receptor-δ gene deletion

Autor: T. M. Breit, M. C. M. Verschuren, Ingrid L. M. Wolvers-Tettero, J. J. M. Van Dongen

Publikováno v: Immunology. 93:208-212

The differentiation mechanisms that force thymocytes into the T-cell receptor (TCR)-alpha beta or TCR-gamma delta lineage are poorly understood, but rearrangement processes in the TCR-alpha/delta locus are likely to play an important role. It is assu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0952321b79ba7053c7ec5fb9eab58498
https://doi.org/10.1046/j.1365-2567.1998.00417.x

Zobrazit plný text záznamu

PJA-BP expression and TCR delta deletion during human T cell differentiation

Autor: Ad J.J.C. Bogers, H. Spits, B. Blom, M. C. M. Verschuren, J. J. M. Van Dongen

Publikováno v: International immunology, 10(12), 1873-1880. Oxford University Press

Recombination of deltaRec to psiJalpha will delete the TCR delta gene, which is thought to play an important role in the bifurcation of the TCR alphabeta versus TCR gammadelta differentiation lineages. We recently detected a DNA-binding protein in hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91af72544b813573a8a2df42ec0f824
https://doi.org/10.1093/intimm/10.12.1873

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání