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Interleukin-10 rescues T cells from apoptotic cell death: association with an upregulation of Bcl-2

Autor: S. B. A. Cohen, J. B. Crawley, M Feldmann, M. C. Kahan, Brian M. J. Foxwell

We demonstrate that interleukin-10 (IL-10) can inhibit T-cell apoptosis. T cells, within a PBMC (peripheral blood mononuclear cell) population, were stimulated via the T-cell receptor and grown in the presence of IL-2. These cells had less apoptosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f6646b0af693e004632f1f717ced81
https://doi.org/10.1046/j.1365-2567.1997.00348.x

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PUVA therapy decreases HLA-DR+ CDIa+ Langerhans cells and epidermal cell antigen-presenting capacity in human skin, but flow cytometrically-sorted residual HLA-DR+ CDIa+ Langerhans cells exhibit normal alloantigen-presenting function

Autor: J, Ashworth, M C, Kahan, S M, Breathnach

Publikováno v: The British journal of dermatology. 120(3)

We have investigated the effects of PUVA therapy on human Langerhans cell (LC) immunophenotype and function. Epidermal sheets were obtained from exposed, and control shielded, forearm skin at the end of a course of PUVA therapy, in patients receiving

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::92377e5a358fc8140952b10dd773ac8f
https://pubmed.ncbi.nlm.nih.gov/2469456

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