Zobrazeno 1 - 10
of 60
pro vyhledávání: '"M. C. Holmes"'
Publikováno v:
Journal of Neuroendocrinology
Mice lacking the intracellular glucocorticoid‐regenerating enzyme 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) are protected from age‐related spatial memory deficits. 11β‐HSD1 is expressed predominantly in the brain, liver and adip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9b37253630f42aeb1b9deffbaf273627
https://pubmed.ncbi.nlm.nih.gov/27859809
https://pubmed.ncbi.nlm.nih.gov/27859809
Autor:
Erica A, Moehle, E A, Moehle, Jeremy M, Rock, J M, Rock, Ya-Li, Lee, Y L, Lee, Yann, Jouvenot, Y, Jouvenot, Russell C, DeKelver, R C, Dekelver, Philip D, Gregory, P D, Gregory, Fyodor D, Urnov, F D, Urnov, Michael C, Holmes, M C, Holmes
Publikováno v:
Proceedings of the National Academy of Sciences. 104:3055-3060
Efficient incorporation of novel DNA sequences into a specific site in the genome of living human cells remains a challenge despite its potential utility to genetic medicine, biotechnology, and basic research. We find that a precisely placed double-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a2c56c8f4e07bb687bd0dd0386d6f1
https://doi.org/10.1073/pnas.0611478104
https://doi.org/10.1073/pnas.0611478104
Autor:
A P, Harris, R J, Lennen, N M, Brydges, M A, Jansen, C R, Pernet, H C, Whalley, I, Marshall, S, Baker, A M, Basso, M, Day, M C, Holmes, J, Hall
Publikováno v:
Genes, Brain, and Behavior
Brain-derived neurotrophic factor (BDNF) signaling is implicated in the etiology of many psychiatric disorders associated with altered emotional processing. Altered peripheral (plasma) BDNF levels have been proposed as a biomarker for neuropsychiatri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a3a3c8681f4a6eea85cf42c51d7e5886
https://pubmed.ncbi.nlm.nih.gov/26586578
https://pubmed.ncbi.nlm.nih.gov/26586578
Autor:
E A, Rog-Zielinska, M-A, Craig, J R, Manning, R V, Richardson, G J, Gowans, D R, Dunbar, K, Gharbi, C J, Kenyon, M C, Holmes, D G, Hardie, G L, Smith, K E, Chapman
Publikováno v:
Cell Death and Differentiation
Glucocorticoid levels rise dramatically in late gestation to mature foetal organs in readiness for postnatal life. Immature heart function may compromise survival. Cardiomyocyte glucocorticoid receptor (GR) is required for the structural and function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b71ec597ed1c2a8a488df6ad35a72e3
https://pubmed.ncbi.nlm.nih.gov/25361084
https://pubmed.ncbi.nlm.nih.gov/25361084
Autor:
M. S. Leaver, M. C. Holmes
Publikováno v:
Journal de Physique II. 3:105-120
The binary lyotropic liquid crystalline system caesium pentadecafluoro-octanoate (CsPFO)/water ( 2 H 2 O) exhibits an isotropic micellar phase, a lyotropic nematic phase and a positionally ordered, lamellar phase whose planes contain substantial wate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef0d7be5db322ca6a8895e0732aca54d
https://doi.org/10.1051/jp2:1993114
https://doi.org/10.1051/jp2:1993114
Autor:
M C Holmes
Publikováno v:
Physics Education. 27:138-141
In what sort of room should students be taught physics? An experiment with one large, multipurpose room reveals advantages for both students and staff.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2e7fa29e2d32ac3d224b6b0af183c2e
https://doi.org/10.1088/0031-9120/27/3/004
https://doi.org/10.1088/0031-9120/27/3/004
Publikováno v:
Liquid Crystals. 11:311-324
The effects of defects on a variety of experiments on monodomain nematic and lamellar phases of the CsPFO/water system are described. In NMR experiments the observed anomalous behaviour depends on whether the sample tube is oriented with its long axi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71dc9fedbc5314c9405124c9ac49674a
https://doi.org/10.1080/02678299208028991
https://doi.org/10.1080/02678299208028991
Autor:
R N, Carter, J M, Paterson, U, Tworowska, D J, Stenvers, J J, Mullins, J R, Seckl, M C, Holmes
Publikováno v:
Journal of Neuroendocrinology
Inter-individual differences in hypothalamic-pituitary-adrenal (HPA) axis activity underlie differential vulnerability to neuropsychiatric and metabolic disorders, although the basis of this variation is poorly understood. 11beta-Hydroxysteroid dehyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bff8198429ee1a78903d0e6315f60d99
https://pubmed.ncbi.nlm.nih.gov/19602102
https://pubmed.ncbi.nlm.nih.gov/19602102
Autor:
M. C. Holmes, K. Hosn, S. Walsh, F. Anvia, Robert W. Taft, G. Oloumi, S. Yazdani, R. Vasanwala, Jean-François Gal, M. Capon
Publikováno v:
Pure and Applied Chemistry. 62:17-23
The effects of molecular structure on gas phase basicity toward Lit has been extensive1y.stud ied. It is shown that both the magnitudes and the basicity orders differ markedly from the corresponding gas phase bacisities toward Ht. An analysis of thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2477ac1e5e2df4597d21b7be276e3c75
https://doi.org/10.1351/pac199062010017
https://doi.org/10.1351/pac199062010017
Publikováno v:
British journal of neurosurgery. 16(6)
Nitric oxide synthase (NOS) has recently been shown to be an important pathophysiological regulator in experimental implantation glioma since manipulation of NOS can significantly alter tumoural blood flow and inhibit tumour growth. In this study we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a64c4a3857ae3d595abe2fbb94ed4ef5
https://pubmed.ncbi.nlm.nih.gov/12617238
https://pubmed.ncbi.nlm.nih.gov/12617238