Abstract 13025: Methotrexate Carried in Lipid Core Nanoparticles Prevented the Dilation and Dissection of the Aortic Arch in Mice With Marfan Syndrome by Increasing the Bioavailability of Intracellular Adenosine

Autor: Natalia M Lopes, Leonardo Jensen, Lygia da Veiga Pereira, Elaine R. Tavares, Francisco R.M. Laurindo, Raul C. Maranhão, M. C. Guido, Camila I Albuquerque

Publikováno v: Circulation. 142

Introduction: Mutations in the fibrillin-1 gene result in aneurysms and rupture of the aorta, the main cause of mortality in patients with Marfan syndrome (MFS). Inflammation is associated with dissection and rupture of the aorta. We showed that meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df14e1e87bb35550852474683888ae55
https://doi.org/10.1161/circ.142.suppl_3.13025

Daunorubicin associated to lipid core nanoparticles reduces atherosclerotic lesions, inflammation and cardiotoxicity in atherosclerosis rabbit model

Autor: Leonardo Jensen, Elaine R. Tavares, C.I Albuquerque, R. V. Baroni, N M Lopes, Thauany M Tavoni, Bruna M. O. Silva, M. C. Guido, Raul C. Maranhão, Roberto Kalil-Filho

Publikováno v: European Heart Journal. 41

Introduction Antiproliferative agents used in cancer chemotherapy have low toxicity and increased pharmacological action when carried into lipid core nanoparticles (LDE). LDE has similar structure to LDL and binds to LDL receptors through apo E it ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e126a23d91ea31e76238766189b74179
https://doi.org/10.1093/ehjci/ehaa946.3792

Methotrexate carried in lipid core nanoparticles reduces myocardial infarction size and improves cardiac function in rats

Autor: Raul C. Maranhão, Marcelo Dantas Tavares de Melo, Roberto Kalil-Filho, Jose C. Nicolau, M. C. Guido, Elaine R. Tavares, A. F. Marques, A. D. Lima, Vera Maria Cury Salemi

Publikováno v: International Journal of Nanomedicine
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Raul C Maranhão,1,2 Maria C Guido,1 Aline D de Lima,1 Elaine R Tavares,1 Alyne F Marques,1 Marcelo D Tavares de Melo,3 Jose C Nicolau,3 Vera MC Salemi,3 Roberto Kalil-Filho3 1Laboratory of Metabolism and Lipids, 2Faculty of Pharmaceutical Sciences,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98b9045e5e2553606e3c129d927b8e7
http://europepmc.org/articles/PMC5440040

P6295Methotrexate reduces cardiac remodeling and improves left ventricle function in rats with Takotsubo cardiomyopathy

Autor: N M Lopes, M. C. Guido, D. L. Bispo, M D Tavares De Melo, Raul C. Maranhão, V.M.C. Salemi, Elaine R. Tavares

Publikováno v: European Heart Journal. 40

Introduction Takotsubo cardiomyopathy (TC) is characterized by cardiac disfunction and left ventricle (LV) remodeling caused, mainly, by physical or emotional stress. Previously, we have shown in atherosclerotic rabbits that methotrexate (MTX), an an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d572e08036aff230255476e29b69e9a3
https://doi.org/10.1093/eurheartj/ehz746.0893

Fibrillin-1 mgΔlpn Marfan syndrome mutation associates with preserved proteostasis and bypass of a protein disulfide isomerase-dependent quality checkpoint

Autor: Thaís L.S. Araujo, Victor Debbas, Patricia Nolasco, M. C. Guido, Thayna Meirelles, Lygia da Veiga Pereira, Francisco R.M. Laurindo, Ana Iochabel Soares Moretti

Publikováno v: The International Journal of Biochemistry & Cell Biology. 71:81-91

Fibrillin-1 mutations promote Marfan syndrome (MFS) via complex yet unclear pathways. The roles of endoplasmic reticulum (ER) and the major ER redox chaperone protein disulfide isomerase-A1 in the processing of normal and mutated fibrillin-1 and ensu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67d877b22201827ca151d74d7f738b79
https://doi.org/10.1016/j.biocel.2015.12.009