Zobrazeno 1 - 10
of 12
pro vyhledávání: '"M. C. Christian"'
Autor:
E. L. Trimble, M. C. Christian
Publikováno v:
International Journal of Gynecologic Cancer. 18:26-28
On the basis of three large randomized phase III trials, the National Cancer Institute (NCI) issued a Clinical Announcement in January 2006 recommending that women with optimally debulked stage III ovarian cancer and their physicians consider a combi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b10ffc914ab4d12224796114ba3e31
https://doi.org/10.1111/j.1525-1438.2007.01100.x
https://doi.org/10.1111/j.1525-1438.2007.01100.x
Autor:
P. T. C. Ho, James M. Pluda, M. C. Christian, J. M. Sorensen, Bruce D. Cheson, Susan G. Arbuck
Publikováno v:
Annals of Oncology. 8:S119-S128
While novel agents designed to target molecular abnormalities involved in lymphoma pathogenesis are most likely to improve current therapeutic results, cytotoxic therapy remains the mainstay of therapy. Several new chemotherapy agents, including puri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92f255add97e33fca3b0f9de5a6bd34d
https://doi.org/10.1093/annonc/8.suppl_1.s119
https://doi.org/10.1093/annonc/8.suppl_1.s119
Autor:
P, Therasse, S G, Arbuck, E A, Eisenhauer, J, Wanders, R S, Kaplan, L, Rubinstein, J, Verweij, M, Van Glabbeke, A T, van Oosterom, M C, Christian, S G, Gwyther
Publikováno v:
Journal of the National Cancer Institute. 92(3)
Anticancer cytotoxic agents go through a process by which their antitumor activity-on the basis of the amount of tumor shrinkage they could generate-has been investigated. In the late 1970s, the International Union Against Cancer and the World Health
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1eea7b045b0279e37a90e4ceb7e8dec7
https://pubmed.ncbi.nlm.nih.gov/16478740
https://pubmed.ncbi.nlm.nih.gov/16478740
Phase I study of a five-day dose schedule of 4-Ipomeanol in patients with non-small cell lung cancer
Autor:
V K, Kasturi, M P, Dearing, S C, Piscitelli, E K, Russell, G G, Sladek, K, O'Neil, G A, Turner, T L, Morton, M C, Christian, B E, Johnson, M J, Kelley
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 4(9)
The mammalian pulmonary toxin 4-ipomeanol (IPO) is activated by the cytochrome P450 system in bronchial Clara cells in animals. The resulting metabolites bind rapidly to macromolecules, producing localized cytotoxicity. IPO has in vitro and in vivo a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::95b5e5f626c0255812564de5574ab150
https://pubmed.ncbi.nlm.nih.gov/9748125
https://pubmed.ncbi.nlm.nih.gov/9748125
Autor:
W D, Figg, M C, Christian, R, Lush, C J, Link, P, Davis, E, Kohn, G, Sarosy, M L, Rothenberg, R B, Weiss, N, Ryan, J, Jacobs, E, Reed
Publikováno v:
Biopharmaceuticsdrug disposition. 18(4)
Preclinical data suggest that ormaplatin (tetrachloro-(dl-trans)-1, 2-diamminocyclohexaneplatinum) has substantial activity in cisplatin-resistant tumor models and may be less nephrotoxic than cisplatin. Based on these data we initiated a phase I cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f68b980118a48489285b1ddb80dde681
https://pubmed.ncbi.nlm.nih.gov/9158882
https://pubmed.ncbi.nlm.nih.gov/9158882
Publikováno v:
Seminars in oncology. 24(2)
The Division of Cancer Treatment, Diagnosis and Centers of the National Cancer Institute (NCI) has a large program in clinical cancer therapeutics development. It currently holds investigational new drug applications for nearly 200 agents with which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fac8d491481ac921845ba42cfeac0f83
https://pubmed.ncbi.nlm.nih.gov/9129691
https://pubmed.ncbi.nlm.nih.gov/9129691
Publikováno v:
Annals of oncology : official journal of the European Society for Medical Oncology. 8
While novel agents designed to target molecular abnormalities involved in lymphoma pathogenesis are most likely to improve current therapeutic results, cytotoxic therapy remains the main-stay of therapy. Several new chemotherapy agents, including pur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc043f9e6513b992930750c4ec213232
https://pubmed.ncbi.nlm.nih.gov/9187445
https://pubmed.ncbi.nlm.nih.gov/9187445
Publikováno v:
Seminars in oncology. 20(4 Suppl 3)
Basic questions regarding optimal dose and schedule of anticancer drug administration frequently persist long after regulatory approval and commercial availability of a drug. For paclitaxel (TAXOL), these questions were considered early in drug devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9bf2494b0a4208c2496eae91f0884869
https://pubmed.ncbi.nlm.nih.gov/8102016
https://pubmed.ncbi.nlm.nih.gov/8102016
Autor:
E K, Rowinsky, D A, Noe, D S, Ettinger, M C, Christian, B G, Lubejko, E K, Fishman, S E, Sartorius, M R, Boyd, R C, Donehower
Publikováno v:
Cancer research. 53(8)
4-Ipomeanol (IPO), a naturally occurring pulmonary toxin, is the first cytotoxic agent to undergo clinical development based on a biochemical-biological rationale as an antineoplastic agent targeted specifically against lung cancer. This rationale is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b8d0a57fa3536a32ad7ceab69bc43663
https://pubmed.ncbi.nlm.nih.gov/8467498
https://pubmed.ncbi.nlm.nih.gov/8467498
Autor:
S G, Arbuck, M C, Christian, J S, Fisherman, L A, Cazenave, G, Sarosy, M, Suffness, J, Adams, R, Canetta, K E, Cole, M A, Friedman
Publikováno v:
Journal of the National Cancer Institute. Monographs. (15)
Taxol is the first of a novel class of anticancer drugs, the taxanes. Taxol's unique effects include its ability to polymerize tubulin into stable microtubules in the absence of cofactors and to induce the formation of stable microtubule bundles. Dur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cc36a1ca9ef2918023e7cfcf97271a72
https://pubmed.ncbi.nlm.nih.gov/7912517
https://pubmed.ncbi.nlm.nih.gov/7912517