Zobrazeno 1 - 10
of 16
pro vyhledávání: '"M. C. Charlesworth"'
Autor:
Robert J. Ryan, Elizabeth R. Bergert, M C Charlesworth, H. Hojo, T. Vutyavanich, Daniel J. McCormick
Publikováno v:
Endocrinology. 127:2977-2984
The glycoprotein hormones CG, LH, FSH, and TSH are composed of two noncovalently linked subunits, alpha and beta. The beta-subunit confers hormone specificity, while the alpha-subunit is homologous within a species. To help in determining the antigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c6ad8fa6c47ff2f1d0da7fa0aa3135e
https://doi.org/10.1210/endo-127-6-2977
https://doi.org/10.1210/endo-127-6-2977
Autor:
S D, Mikolajczyk, L S, Millar, K M, Marker, H G, Rittenhouse, R L, Wolfert, L S, Marks, M C, Charlesworth, D J, Tindall
Publikováno v:
Cancer research. 59(16)
Human kallikrein (hK) 2 is an arginine-selective serine protease expressed predominantly in the prostate that has an 80% sequence identity with prostate-specific antigen. Expression of hK2 is elevated in the tumor epithelium compared to benign prosta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7dfa166af28a02e677ad244878709eb1
https://pubmed.ncbi.nlm.nih.gov/10463585
https://pubmed.ncbi.nlm.nih.gov/10463585
Publikováno v:
Journal of andrology. 20(2)
Prostate-specific human glandular kallikrein (hK2) is an active enzyme in human seminal fluid. It is one of three serine proteases in the human kallikrein gene family, which includes hK1 (tissue kallikrein) and hK3 (prostate-specific antigen [PSA]).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4c527a3553c5d59b01d9b831717ee665
https://pubmed.ncbi.nlm.nih.gov/10232657
https://pubmed.ncbi.nlm.nih.gov/10232657
Autor:
L S, Grauer, M C, Charlesworth, M S, Saedi, J A, Finlay, R S, Liu, K, Kuus-Reichel, C Y, Young, D J, Tindall
Publikováno v:
Journal of andrology. 17(4)
Based on studies indicating that human glandular kallikrein (hK2) mRNA is present in the prostate, we prepared a monoclonal antibody to a synthetic peptide corresponding to the 41-56 region of hK2 to try to identify the hK2 protein. Although prostate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6646a2e051ae1f8e9ccbd25d7f1d07e2
https://pubmed.ncbi.nlm.nih.gov/8889697
https://pubmed.ncbi.nlm.nih.gov/8889697
Publikováno v:
The Prostate. Supplement. 7
Although prostate-specific antigen (PSA) has aided significantly in the diagnosis of prostate cancer, more sensitive and accurate assays are needed. Presently, we are developing a sensitive immunoassay for hK2 protein for the detection of prostate ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eced63b73c2ce274269d0386046ac875
https://pubmed.ncbi.nlm.nih.gov/8950360
https://pubmed.ncbi.nlm.nih.gov/8950360
Publikováno v:
Endocrinology. 128(6)
Twenty-seven synthetic peptides, representing the entire structure of the human glycoprotein hormone αsubunit were used to map the antigenic structure of the αsubunit. Solution phase and solid phase assays were performed with these peptides and a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e813ef0983a59d9a07513b71a7e87ddb
https://pubmed.ncbi.nlm.nih.gov/2036968
https://pubmed.ncbi.nlm.nih.gov/2036968
Autor:
Robert J. Ryan, S A Rizza, M C Charlesworth, L D Erickson, Elizabeth R. Bergert, Daniel J. McCormick
Publikováno v:
Endocrinology. 126(5)
The glycoprotein hormones (LH, hCG, FSH, and TSH) have a common 92-amino acid alpha-subunit which is noncovalently linked to a hormone-specific beta-subunit. Synthetic peptides of the alpha-subunit have been shown to inhibit binding of [125I]iodo-hCG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f481d84646aa4ba2eb0e54898768a1f
https://pubmed.ncbi.nlm.nih.gov/1691699
https://pubmed.ncbi.nlm.nih.gov/1691699
Publikováno v:
British Journal of Ophthalmology. 72:299-302
A 50-year-old Asian male presented with a left sixth nerve palsy, left temporal pain, and rapidly deteriorating visual acuity in the left eye. A high resolution CT scan and magnetic resonance scan showed a left retro-orbital enhancing lesion extendin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b712b697d7a2370f08d3df3d04144106
https://doi.org/10.1136/bjo.72.4.299
https://doi.org/10.1136/bjo.72.4.299
Publikováno v:
Journal of Biological Chemistry. 262:13409-13416
Synthetic overlapping peptides of the alpha-subunit of human chorionic gonadotropin (hCG) were made by solid-phase peptide synthesis employing a comprehensive synthetic approach. The entire primary structure of the alpha-subunit was synthesized as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff1c0aea4425b54673cc03e78305f68c
https://doi.org/10.1016/s0021-9258(19)76441-2
https://doi.org/10.1016/s0021-9258(19)76441-2
Autor:
N. B. Schwartz, M. C. Charlesworth
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 250:E341-E345
Follicle-stimulating hormone (FSH) levels are not suppressed as rapidly or to the same degree as luteinizing hormone (LH) levels in ovariectomized rats treated with either gonadotropin-releasing hormone (GnRH) antagonist or estrogen. The acute inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3191d22ea19c04718e54126ef34f423
https://doi.org/10.1152/ajpendo.1986.250.4.e341
https://doi.org/10.1152/ajpendo.1986.250.4.e341