NEMO‐Binding Domain/IKKγ Inhibitory Peptide Alleviates Neuronal Pyroptosis in Spinal Cord Injury by Inhibiting ASMase‐Induced Lysosome Membrane Permeabilization.

Autor: Geng, Yibo^1,2 (AUTHOR), Lou, Junsheng³ (AUTHOR), Wu, Junnan⁴ (AUTHOR), Tao, Zhichao⁵ (AUTHOR), Yang, Ningning^1,2 (AUTHOR), Kuang, Jiaxuan⁶ (AUTHOR), Wu, Yuzhe^1,2 (AUTHOR), Zhang, Jiacheng^1,2 (AUTHOR), Xiang, Linyi^1,2 (AUTHOR), Shi, Jingwei⁶ (AUTHOR), Cai, Yuepiao^6,7 (AUTHOR), Wang, Xiangyang^1,2 (AUTHOR) xiangyangwang@wmu.edu.cn, Chen, Jiaoxiang^1,2 (AUTHOR) jiaoxiangchen@wmu.edu.cn, Xiao, Jian^6,7 (AUTHOR) xfxj2000@126.com, Zhou, Kailiang^1,2,6 (AUTHOR) zhoukailiang@wmu.edu.cn

Publikováno v: Advanced Science. 10/28/2024, Vol. 11 Issue 40, p1-22. 22p.

Identification of phosphatidylcholine-selective and phosphatidylinositol-selective phospholipases D in Madin-Darby canine kidney cells

Autor: Larry W. Daniel, Robert L. Wykle, Chunfa Huang, M. C. Cabot

Publikováno v: Journal of Biological Chemistry. 267:16859-16865

Intact cells and cell-free systems were employed to characterize phospholipase D (PLD) activity in Madin-Darby canine kidney (MDCK) cells. In cells prelabeled with [3H]glycerol, 12-O-tetradecanoylphorbol-13-acetate (TPA) elicited phosphatidylcholine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc7bdba38eda8bf113489be777326d24
https://doi.org/10.1016/s0021-9258(18)41863-7

Phorbol diesters stimulate the accumulation of phosphatidate, phosphatidylethanol, and diacylglycerol in three cell types. Evidence for the indirect formation of phosphatidylcholine-derived diacylglycerol by a phospholipase D pathway and direct formation of diacylglycerol by a phospholipase C pathway

Autor: C F Huang, M C Cabot

Publikováno v: Journal of Biological Chemistry. 265:14858-14863

The effect of the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), on phospholipid degradation was investigated in three cell lines of dissimilar origin, Madin-Darby canine kidney cells (MDCK), rat aorta smooth muscle cells (RASM), and bov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f83c93995ac07984319025c303871483
https://doi.org/10.1016/s0021-9258(18)77193-7

SDZ PSC 833, the cyclosporine A analogue and multidrug resistance modulator, activates ceramide synthesis and increases vinblastine sensitivity in drug-sensitive and drug-resistant cancer cells

Autor: M C, Cabot, A E, Giuliano, T Y, Han, Y Y, Liu

Publikováno v: Cancer research. 59(4)

Resistance to chemotherapy is the major cause of cancer treatment failure. Insight into the mechanism of action of agents that modulate multidrug resistance (MDR) is instrumental for the design of more effective treatment modalities. Here we show, us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2ccde8e728a6e92c85bc6d49e12d894e
https://pubmed.ncbi.nlm.nih.gov/10029079

Glucosylceramide: a marker for multiple-drug resistant cancers

Autor: A, Lucci, W I, Cho, T Y, Han, A E, Giuliano, D L, Morton, M C, Cabot

Publikováno v: Anticancer research. 18(1B)

Multiple-drug resistance (MDR) is a major reason for chemotherapy failure. Herein we describe glucosylceramide, a new marker for MDR.Cellular lipids were analyzed in three human MDR cancer cell lines and their drug-sensitive counterparts. Analysis of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0a51d28f573764d7ffdc5e622331dde9
https://pubmed.ncbi.nlm.nih.gov/9568165