Výsledky vyhledávání - "M. C. Brahimi-Horn"

Haemoglobin interferes with the ex vivo luciferase luminescence assay: consequence for detection of luciferase reporter gene expression in vivo

Autor: Charles Coutelle, Morvane Colin, S Moritz, M C Brahimi-Horn, Jacqueline Capeau, Holm Schneider

Publikováno v: Gene Therapy. 7:1333-1336

The luciferase reporter gene is a useful tool for determining the efficacy of transfection of plasmid DNA and adenovirus-mediated gene transfer in vivo. However, we report here that the haemoglobin present in tissue samples can mask the detection of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7bf92a540db403adca60c27b7eab22e
https://doi.org/10.1038/sj.gt.3301248

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Cell delivery, intracellular trafficking and expression of an integrin-mediated gene transfer vector in tracheal epithelial cells

Autor: Andrew D. Miller, R. G. Cooper, Richard P. Harbottle, G Trugnan, Michèle Maurice, Charles Coutelle, Andrew T. Knight, M C Brahimi-Horn, M Kornprobst, Jacqueline Capeau, Morvane Colin

Publikováno v: Gene Therapy. 7:139-152

The mechanism of cell entry and intracellular fate of a gene transfer vector composed of a receptor-targeting, DNA-condensing peptide, RGD-oligolysine, a luciferase encoding plasmid DNA (pDNA) and a cationic liposome was examined. We demonstrate by c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::941d843dc7bdba5bba23166518da1cdd
https://doi.org/10.1038/sj.gt.3301056

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Lipolytic activity produced by Pseudomonas aeruginosa and Acinetobacter calcoaceticus strains grown in wool-scour effluent

Autor: L.G. Sparrow, A. M. Gaal, M.G. Guglielmino, C. A. Mickelson, M.-C. Brahimi-Horn

Publikováno v: Enzyme and Microbial Technology. 13:740-746

Two bacterial isolates from a mixed microbial culture able to degrade wool-scour effluent were found to synthesize and produce lipolytic activity. The growth, esterase production, and wool grease degradation by these strains, a Pseudomonas aeruginosa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6124e1dd0e921d5a3c5b0a730c9c22b2
https://doi.org/10.1016/0141-0229(91)90053-d

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Identification of lipolytic activity in a multitrophic population grown in wool-scour effluent

Autor: L. G. Sparrow, A. M. Gaal, C. A. Mickelson, M. C. Brahimi-Horn, M. L. Guglielmino

Publikováno v: Journal of Industrial Microbiology. 8:53-58

A multitrophic population established in wool-scour effluent produced esterase activity with specificity to steryl, wax and triacylglyceryl esters. The wax esterase activity peaked just prior to the esterase activity toward cholesteryl oleate andp-ni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::adf6b16547a68f1acc819d0fc2144877
https://doi.org/10.1007/bf01575591

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Protein kinases and the hypoxia-inducible factor-1, two switches in angiogenesis

Autor: Nathalie M. Mazure, Jacques Pouysségur, M. C. Brahimi-Horn

Publikováno v: Current Pharmaceutical Design
Current Pharmaceutical Design, Bentham Science Publishers, 2003, 9 (7), pp.531-41

International audience; In the last few decades it has become clear that detailed understanding of the mechanisms of angiogenesis, a process leading to growth of new blood vessels, should lead to improved treatment of diseases such as ischemic disord

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ea159069e7d9012dcec4e16bd9b8ed
https://hal.archives-ouvertes.fr/hal-00322775

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Gene transfer by adenovirus-mimetic peptides in the presence of a cationic lipid and/or adenovirus. Analysis of the contribution of the viral and nonviral components

Autor: S Moritz, Michael D. Keller, Charles Coutelle, Jacqueline Capeau, J. Chroboczek, Morvane Colin, M C Brahimi-Horn, B. Klonjkowski

Publikováno v: Archives of Virology
Archives of Virology, Springer Verlag, 2003, 148 (1), pp.1-18

International audience; Peptide and cationic lipid-based gene transfer vectors have shown promise for gene therapy but are still less efficient than viral gene transfer vectors. We have examined the mechanism of gene transfer of different adenovirus-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96ff0263a7fb55bdcf7cd9758707ed8
https://hal.inrae.fr/hal-02676315

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The nuclear pore complex is involved in nuclear transfer of plasmid DNA condensed with an oligolysine-RGD peptide containing nuclear localisation properties

Autor: P Fontanges, M C Brahimi-Horn, Jacqueline Capeau, S Moritz, Morvane Colin, Andrew D. Miller, Michel Kornprobst, Charles Coutelle, C Delouis, Michael D. Keller

Publikováno v: Gene therapy. 8(21)

One of the major barriers to efficient gene transfer and expression of nonviral vectors for gene therapy is passage across the nuclear envelope. We have previously shown that an oligolysine-RGD peptide that condenses plasmid DNA and binds to cell sur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d3645ada730b0e7592c0dfb381738a
https://pubmed.ncbi.nlm.nih.gov/11895003

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Characterisation of LMD virus-like nanoparticles self-assembled from cationic liposomes, adenovirus core peptide mu and plasmid DNA

Autor: Michael D. Keller, Nick Brown, F. Booy, Andrew D. Miller, Richard P. Harbottle, Toshiaki Tagawa, Karl Murray, Eric W.F.W. Alton, Eric Perouzel, M C Brahimi-Horn, Charles Coutelle, Michelle C Manvell, M. Tecle, Nicholas R. Lemoine

Publikováno v: Gene therapy. 9(9)

Liposome:mu:DNA (LMD) is a ternary nucleic acid delivery system built around the mu peptide associated with the condensed core complex of the adenovirus. LMD is prepared by precondensing plasmid DNA (D) with mu peptide (M) in a 1:0.6 (w/w) ratio and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f47cba95acf8a0486686fde8684514e
https://pubmed.ncbi.nlm.nih.gov/11973632

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Liposomes enhance delivery and expression of an RGD-oligolysine gene transfer vector in human tracheal cells

Autor: M C Brahimi-Horn, Richard P. Harbottle, Morvane Colin, G Trugnan, A Knight, Charles Coutelle, Andrew D. Miller, R. G. Cooper, M Kornprobst, Jacqueline Capeau

Publikováno v: Gene therapy. 5(11)

Nonviral gene delivery systems consist predominantly of lipoplexes or receptor-targeting and nontargeting polyplexes. We examined integrin-mediated gene delivery using an Arg-Gly-Asp/oligo-L-lysine ([K]16RGD) cyclic peptide and investigated its gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df4288bd4dda40f04f5e82a0cb75fac4
https://pubmed.ncbi.nlm.nih.gov/9930302

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CFTR gene transfer corrects defective glycoconjugate secretion in human CF epithelial tracheal cells

Autor: Mustapha Lemnaouar, A. Paul, Jean-Yves Picard, M.-C. Brahimi-Horn, D. C. Gruenert, D. Veissiere, M. Perricaudet, Martine Mergey, Jacqueline Capeau

Publikováno v: The American journal of physiology. 269(6 Pt 1)

We demonstrate that in immortalized normal human tracheal epithelial cells (NT-1 and 56FHTE8o-) 14C-labeled glycoconjugate secretion may be regulated independently by agonists of the protein kinase A (PKA) and protein kinase C (PKC) signaling pathway

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7017f4d3798aec95a0550c010069be79
https://pubmed.ncbi.nlm.nih.gov/8572248

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