Zobrazeno 1 - 10
of 18
pro vyhledávání: '"M. C. Bertomeu"'
Publikováno v:
Blood. 81:3303-3312
HE INTACT endothelial cell (EC) lining of the vascuT lar wall is not reactive to the circulating blood However, ECs acquire thrombogenic properties when they are stimulated by cytokines or thrombin, as shown both in vivo and in vitro. Thus, there is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90d6991676d27e19a68fb2871388a432
https://doi.org/10.1182/blood.v81.12.3303.3303
https://doi.org/10.1182/blood.v81.12.3303.3303
Autor:
Eva Bastida, T A Haas, M. C. Bertomeu, D Lauri, F. William Orr, Sharon Gallo, Michael R. Buchanan
Publikováno v:
Clinical & Experimental Metastasis. 11:243-250
Previously, we have demonstrated that stimulation of endothelial cells (ECs) with interleukin-1 alpha (IL-1 alpha) enhances the synthesis and expression of the vitronectin receptor (VnR), promotes VnR-dependent adhesion of human A549 adenocarcinoma c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d60476ae1b56f3feaf3e21e2921349
https://doi.org/10.1007/bf00121167
https://doi.org/10.1007/bf00121167
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1051:174-178
The 15-omega-lipoxygenase enzyme in endothelial cells metabolizes endogenous linoleic acid (18:2) into 13-hydroxyoctadecadienoic acid (13-HODE) under basal conditions, i.e., in unstimulated endothelial cells. 13-HODE is thought to regulate the non-ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d8d0d679b54c11cb0c1fe33b7597cb
https://doi.org/10.1016/0167-4889(90)90190-o
https://doi.org/10.1016/0167-4889(90)90190-o
Publikováno v:
Agents and Actions. 29:16-20
The majority of studies on fatty acid metabolism, not only via the lipoxygenase pathway, but also via the cyclo-oxygenase pathway, have focused on arachidonic acid. In addition, the majority of the studies have utilized the inhibitor/add-back approac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9c3c622f1924ef94aa20a6549c71291
https://doi.org/10.1007/bf01964707
https://doi.org/10.1007/bf01964707
Publikováno v:
Clinical & Experimental Metastasis. 8:511-518
Recent studies indicate that chemotherapy is a cause for thrombosis in breast cancer patients. We performed experiments to determine whether the enhanced thrombosis was due, in part, to an effect of chemotherapy on endothelial cell reactivity. Hepari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d495e5bc501ac4164b2bb7dd0003cd1e
https://doi.org/10.1007/bf00135874
https://doi.org/10.1007/bf00135874
Publikováno v:
Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury ISBN: 9781461365624
Tumor cells (TC)/vascular endothelial cell (EC) adhesion is important in metastasis. In vitro studies indicate that the EC linoleic acid (18:2) derived monohydroxide, 13-HODE 1/αwith TC/EC adhesion and with EC expression of the vitronectin receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8bed65876a0a494ebdb7c082c1d63f3
https://doi.org/10.1007/978-1-4615-3520-1_121
https://doi.org/10.1007/978-1-4615-3520-1_121
Publikováno v:
Agents and actions. Supplements. 37
Antiplatelet +/- anticoagulant drugs are currently used as the standard treatment to prevent and treat thrombosis. While this approach is beneficial, it is not optimal. Recent evidence suggests that constituents of the vascular endothelium play an im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c2a9ed062f5e3aa6db94bc2332236f29
https://pubmed.ncbi.nlm.nih.gov/1632301
https://pubmed.ncbi.nlm.nih.gov/1632301
Publikováno v:
Advances in prostaglandin, thromboxane, and leukotriene research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::05308afd9685567390a7b09446c828a4
https://pubmed.ncbi.nlm.nih.gov/1825395
https://pubmed.ncbi.nlm.nih.gov/1825395
Publikováno v:
Wiener klinische Wochenschrift. 103(14)
Endothelial cells synthesize two important fatty acid metabolites, PGI2, which is synthesized from arachidonic acid via the cyclooxygenase pathway, and 13-HODE, which is synthesized from linoleic acid via the lipoxygenase pathway. PGI2 is synthesized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4a3743211374f3b694b8e1ccb53c2f2b
https://pubmed.ncbi.nlm.nih.gov/1718092
https://pubmed.ncbi.nlm.nih.gov/1718092
Publikováno v:
Atherosclerosis ISBN: 9781461366720
Platelet interactions with the blood vessel wall following injury influence both the acute thrombotic event (platelet/vessel wall adhesion) and the chronic pathogenesis of arteriosclerosis (chronic vessel wall thickening and occlusion). Platelets are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34d5e69fc4ed4bbe2ef6b31532c94f4a
https://doi.org/10.1007/978-1-4615-3754-0_17
https://doi.org/10.1007/978-1-4615-3754-0_17