Výsledky vyhledávání - "M. C. Alpoim"

Cytotoxic mechanism of sphaerodactylomelol, an uncommon bromoditerpene isolated from sphaerococcus coronopifolius

Autor: Luis M. Botana, Joana Silva, Adriana Yumi Sato Duarte, Helena Gaspar, M. C. Alpoim, Celso Alves, Rebeca Alvariño, Amparo Alfonso, Susete Pinteus, Eva Alonso, Diorge Jônatas Marmitt, Márcia Inês Goettert, Rui Pedrosa

Publikováno v: Minerva: Repositorio Institucional de la Universidad de Santiago de Compostela
Universidad de Santiago de Compostela (USC)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Molecules
Volume 26
Issue 5
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname
Molecules, Vol 26, Iss 1374, p 1374 (2021)

Marine natural products have exhibited uncommon chemical structures with relevant antitumor properties highlighting their potential to inspire the development of new anticancer agents. The goal of this work was to study the antitumor activities of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e978e0c5fc1d2e02db79c12eb3569c34
https://hdl.handle.net/10400.8/5960

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Stroma-derived IL-6, G-CSF and Activin-A mediated dedifferentiation of lung carcinoma cells into cancer stem cells

Autor: Eurico Serrano, Lina Carvalho, Luís Pereira de Almeida, Isabel M. Carreira, Joao Fonseca, M. Filomena Botelho, Célia Gomes, Patrícia Albuquerque, M. C. Alpoim, Carlos Fernando Dias Rodrigues, Maria I. Patrício, Mariana Val, Artur Paiva, Antero J. Abrunhosa

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports

Cancer stem cells (CSCs) are a small population of resistant cells inhabiting the tumors. Although comprising only nearly 3% of the tumor mass, these cells were demonstrated to orchestrate tumorigenesis and differentiation, underlie tumors’ heterog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::326dd2a787280784fc4dc5f40d9d61f0
https://doaj.org/article/6bb37cff1bbf4fc29ff5c570d306e16b

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Sphaerococcus coronopifolius bromoterpenes as potential cancer stem celltargeting agents

Autor: Rui Pedrosa, Carlos Rodrigues, Celso Alves, Helena Gaspar, Luis M. Botana, Joana Silva, Eurico Serrano, Susete Pinteus, M. C. Alpoim

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Biomedicine & Pharmacotherapy, Vol 128, Iss, Pp 110275-(2020)

Acknowledgments This work was supported by the Portuguese Foundation for Science and Technology (FCT) through strategic project UID/MAR/04292/ 2020 and UID/Multi/04046/2020 granted to MARE—Marine and Environmental Sciences Centre and BioISI—BioSy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb2faa604d146236bb59e8342dd39a68
https://hdl.handle.net/10400.8/5931

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HSP90: A Key Player in Metal-Induced Carcinogenesis?

Autor: Teresa Cunha-Oliveira, Patrícia L. Abreu, Leonardo M. R. Ferreira, Ana M. Urbano, M. C. Alpoim

Publikováno v: Heat Shock Proteins ISBN: 9783030231576

Three extensively used metals, cadmium, chromium and nickel, are established human carcinogens. The elucidation of the molecular and cellular mechanisms underlying the carcinogenicity of these metals has centered mostly on the signalling pathways tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d298f605c36d0a52d78031ad1b36b4ae
https://doi.org/10.1007/978-3-030-23158-3_11

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Impact of hexavalent chromium on mammalian cell bioenergetics: phenotypic changes, molecular basis and potential relevance to chromate-induced lung cancer

Autor: Patrícia L. Abreu, Leonardo M. R. Ferreira, Ana M. Urbano, M. C. Alpoim

Publikováno v: BioMetals. 27:409-443

Occupational exposure to hexavalent chromium [Cr(VI)] has been firmly associated with the development of several pathologies, notably lung cancer. According to the current paradigm, the evolution of normal cells to a neoplastic state is accompanied b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dedca67400ec24e1ea4eea5df7315572
https://doi.org/10.1007/s10534-014-9726-7

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Molecular and Cellular Mechanisms of Hexavalent Chromium-Induced Lung Cancer: An Updated Perspective

Autor: Ana M. Urbano, Leonardo M. R. Ferreira, M. C. Alpoim

Publikováno v: Current Drug Metabolism. 13:284-305

For over a century, chromium (Cr) has found widespread industrial and commercial use, namely as a pigment, in the production of stainless steel and in chrome plating. The adverse health effects to the skin and respiratory tract of prolonged exposure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63eed908faea98b423677701b25f261d
https://doi.org/10.2174/138920012799320464

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Changes in glucose uptake rate and in the energy status of PC-12 cells acutely exposed to hexavalent chromium, an established human carcinogen

Autor: Ana Catarina Calado Santos, Maria S. Santos, André Nuno Costa, Pedro Coelho, Ana M. Urbano, Carlos Fernando Dias Rodrigues, Maria João Gonçalves, M. C. Alpoim, A.J. Guiomar

Publikováno v: Toxicological & Environmental Chemistry. 93:1202-1211

In the 1920s, Otto Warburg reported a striking metabolic shift in solid tumors: contrary to their normal counter parts, which exhibited a nearly pure respiratory metabolism, where cancer cells relied strongly on lactic fermentation for energy product

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ff882ddcbe3c1964e8f3db596127ac7
https://doi.org/10.1080/02772248.2011.581340

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Human bronchial epithelial cells malignantly transformed by hexavalent chromium exhibit an aneuploid phenotype but no microsatellite instability

Autor: M. C. Alpoim, Carlos Fernando Dias Rodrigues, André Nuno Costa, A. Almeida, Eunice Matoso, Filomena Botelho, Isabel M. Carreira, Lina Carvalho, Carolino Monteiro, Virtudes Moreno, P. Santos, Ana M. Urbano, Margarida Alves

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Hexavalent chromium [Cr(VI)] is a well-recognized human lung carcinogen. In order to gain further insight into Cr(VI)-induced carcinogenesis, we have established an adequate in vitro cellular model for the study of this process. To this end, BEAS-2B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44f57a0915e64a1115f54277451e66da
https://doi.org/10.1016/j.mrfmmm.2009.07.004

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Diversity of chromium-resistant and -reducing bacteria in a chromium-contaminated activated sludge

Autor: Paula V. Morais, M. C. Alpoim, Romeu Francisco

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

R . F R A N C I S C O , M . C . A L P O I M A N D P . V . M O R A I S . 2002. Aims: This study attempts to establish a relationship between the Cr(VI) resistance of the culturable microbial community and the Cr(VI) resistance and Cr(VI)-reducing abil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c03469a005cdc9d62e646ae853adadc1
https://doi.org/10.1046/j.1365-2672.2002.01591.x

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Chromium(VI) interaction with plant and animal mitochondrial bioenergetics: A comparative study

Autor: Vítor M.C. Madeira, M. C. Alpoim, Joaquim A.F. Vicente, Maria A.S. Fernandes, Maria S. Santos

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

The mechanism of Cr(VI)-induced toxicity in plants and animals has been assessed for mitochondrial bioenergetics and membrane damage in turnip root and rat liver mitochondria. By using succinate as the respiratory substrate, ADP/O and respiratory con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7226c934a61593d674c7021d486662b
https://doi.org/10.1002/jbt.10025

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