Zobrazeno 1 - 10
of 485
pro vyhledávání: '"M. Buffa"'
Autor:
Enric Domingo, Sanjay Rathee, Andrew Blake, Leslie Samuel, Graeme Murray, David Sebag-Montefiore, Simon Gollins, Nicholas West, Rubina Begum, Susan Richman, Phil Quirke, Keara Redmond, Aikaterini Chatzipli, Alessandro Barberis, Sylvana Hassanieh, Umair Mahmood, Michael Youdell, Ultan McDermott, Viktor Koelzer, Simon Leedham, Ian Tomlinson, Philip Dunne, Francesca M. Buffa, Timothy S. Maughan, Francesca Buffa, Geoffrey Higgins, Christopher Holmes, Timothy Maughan, Gillies McKenna, James Robineau, Philip Quirke, Matthew Seymour, Richard Kennedy, Mark Lawler, Manuel Salto-Tellez, Peter Campbell, Claire Hardy, Simon Bach, Andrew Beggs, Jean-Baptiste Cazier, Gary Middleton, Dion Morton, Celina Whalley, Louise Brown, Richard Kaplan, Richard Wilson, Richard Adams, Richard Sullivan, Paul Harkin, Steven Walker, Jim Hill, Chieh-Hsi Wu, Dennis Horgan
Publikováno v:
EBioMedicine, Vol 106, Iss , Pp 105228- (2024)
Summary: Background: It is uncertain which biological features underpin the response of rectal cancer (RC) to radiotherapy. No biomarker is currently in clinical use to select patients for treatment modifications. Methods: We identified two cohorts o
Externí odkaz:
https://doaj.org/article/6732596b11c54a618ebd9beb8dd8725c
Autor:
Benjamin H. L. Harris, Matteo Di Giovannantonio, Ping Zhang, David A. Harris, Simon R. Lord, Naomi E. Allen, Tim S. Maughan, Richard J. Bryant, Adrian L. Harris, Gareth L. Bond, Francesca M. Buffa
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Cancer risk is associated with the widely debated measure body mass index (BMI). Fat mass and fat-free mass measurements from bioelectrical impedance may further clarify this association. The UK Biobank is a rare resource in which bioelectri
Externí odkaz:
https://doaj.org/article/2f3050f839a7488a9330c4b7083a5352
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Artificial intelligence (AI) techniques are increasingly applied across various domains, favoured by the growing acquisition and public availability of large, complex datasets. Despite this trend, AI publications often suffer from lack of re
Externí odkaz:
https://doaj.org/article/10be48a67e44427ba72374df1179b214
Autor:
Gonzalo Rodriguez-Berriguete, Rathi Puliyadi, Nicole Machado, Alessandro Barberis, Remko Prevo, Martin McLaughlin, Francesca M. Buffa, Kevin J. Harrington, Geoff S. Higgins
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Immune checkpoint blockade (ICB) provides effective and durable responses for several tumour types by unleashing an immune response directed against cancer cells. However, a substantial number of patients treated with ICB develop relapse or
Externí odkaz:
https://doaj.org/article/5dbc7022b8d548e28086316032aa0121
Publikováno v:
Chemical Engineering Transactions, Vol 32 (2013)
Ultra high pressure homogenization (UHPH) is a non-thermal technology capable of producing emulsions, inducing microbial and enzymatic inactivation and confering new functional characteristics, due to changes in the structures of produced foods. Emul
Externí odkaz:
https://doaj.org/article/7b06ff5050384ab7b11b48f0b261e18b
Autor:
Pahala Gedara Jayathilake, Pedro Victori, Clara E Pavillet, Chang Heon Lee, Dimitrios Voukantsis, Ana Miar, Anjali Arora, Adrian L Harris, Karl J Morten, Francesca M Buffa
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 3, p e1011944 (2024)
Deregulated metabolism is one of the hallmarks of cancer. It is well-known that tumour cells tend to metabolize glucose via glycolysis even when oxygen is available and mitochondrial respiration is functional. However, the lower energy efficiency of
Externí odkaz:
https://doaj.org/article/0eb01951447743aaa95598c797984cf8
Autor:
G. P. Ralli, R. D. Carter, D. R. McGowan, W.-C. Cheng, D. Liu, E. J. Teoh, N. Patel, F. Gleeson, A. L. Harris, S. R. Lord, F. M. Buffa, J. D. Fenwick
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-13 (2022)
Abstract Background PET imaging of 18F-fluorodeoxygucose (FDG) is used widely for tumour staging and assessment of treatment response, but the biology associated with FDG uptake is still not fully elucidated. We therefore carried out gene set enrichm
Externí odkaz:
https://doaj.org/article/476c72a2a3d7438a9dd7b06828b8e8e5
Autor:
Shaliny Ramachandran, Tiffany S. Ma, Jon Griffin, Natalie Ng, Iosifina P. Foskolou, Ming-Shih Hwang, Pedro Victori, Wei-Chen Cheng, Francesca M. Buffa, Katarzyna B. Leszczynska, Sherif F. El-Khamisy, Natalia Gromak, Ester M. Hammond
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Hypoxia induces a change in transcriptional response in mammalian cells. Here the authors reveal a role for the RNA/DNA helicase Senataxin in protecting cells from DNA damage induced during transcription in hypoxia.
Externí odkaz:
https://doaj.org/article/53d171bea0d243d0a270df932d095042
Autor:
Masahiro Kawashima, Karim Bensaad, Christos E. Zois, Alessandro Barberis, Esther Bridges, Simon Wigfield, Christoffer Lagerholm, Ruslan I. Dmitriev, Mariko Tokiwa, Masakazu Toi, Dmitri B. Papkovsky, Francesca M. Buffa, Adrian L. Harris
Publikováno v:
Cancer & Metabolism, Vol 8, Iss 1, Pp 1-17 (2020)
Abstract Background Humans produce heat through non-shivering thermogenesis, a metabolic process that occurs in inducible beige adipocytes expressing uncoupling protein 1 (UCP1). UCP1 dissipates the proton gradient of the mitochondrial inner membrane
Externí odkaz:
https://doaj.org/article/a96cf4bb69114d90a113662840c1fdd4
Autor:
Rebecca Carter, Azadeh Cheraghchi-Bashi, Adam Westhorpe, Sheng Yu, Yasmin Shanneik, Elena Seraia, Djamila Ouaret, Yasuhiro Inoue, Catherine Koch, Jenny Wilding, Daniel Ebner, Anderson J. Ryan, Francesca M. Buffa, Ricky A. Sharma
Publikováno v:
Cancer Biology & Medicine, Vol 16, Iss 2, Pp 234-246 (2019)
Objective Patients with BRAF-mutant colorectal cancer (CRC) have a poor prognosis. Molecular status is not currently used to select which drug to use in combination with radiotherapy. Our aim was to identify drugs that radiosensitise CRC cells with k
Externí odkaz:
https://doaj.org/article/20f6deba4d8f477f8d7767514aae6c9b